DegronMD

Uniprot ID: Q9H788

Source protein: SH2 domain-containing protein 4A

Source gene: SH2D4A

Class: DEG_APCC_KENBOX_2

Location: 59:63

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5489

ASA_SCORE: 116.22

COIL: 0.9096

CONS_SCORE: 0.4787

DSS_SCORE: 0.4992

HELIX: 0.037

FCONS_SCORE: 0.8193

RIG_SCORE: 0.6291

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E61D	TCGA-06-5416	GBM	TCGA	KKENG	DEG_APCC_KENBOX_2	0.6758
p.H67Y	TCGA-AJ-A2QM	UCEC	TCGA	KKENG	DEG_APCC_KENBOX_2	0.2222
p.W68R	TCGA-AJ-A3EK	UCEC	TCGA	KKENG	DEG_APCC_KENBOX_2	0.1944
p.E64K	DO51948	BLCA	ICGC	KKENG	DEG_APCC_KENBOX_2	0.3056
p.S73C	DO219076	BLCA	ICGC	KKENG	DEG_APCC_KENBOX_2	0.0556
p.E55K	DO785	BLCA	ICGC	KKENG	DEG_APCC_KENBOX_2	0.6667
p.C49F	DO49058	HNSC	ICGC	KKENG	DEG_APCC_KENBOX_2	0.5
p.E64D	DO229036	LICA	ICGC	KKENG	DEG_APCC_KENBOX_2	0.3056
p.E67D	DO229037	LICA	ICGC	KKENG	DEG_APCC_KENBOX_2	0.2222
p.R58Q	DO41871	UCEC	ICGC	KKENG	DEG_APCC_KENBOX_2	0.3056
p.K70T	DO42713	UCEC	ICGC	KKENG	DEG_APCC_KENBOX_2	0.1389
p.E50K	SIDM01175	Other Sarcomas	GDSC	KKENG	DEG_APCC_KENBOX_2	0.0833
p.E50K	ACH-002309	Sarcoma	CCLE	KKENG	DEG_APCC_KENBOX_2	0.0833
p.E50K	SW684	soft_tissue	COSMIC	KKENG	DEG_APCC_KENBOX_2	0.0833
p.L52M	SIDM00789	Colorectal Carcinoma	GDSC	KKENG	DEG_APCC_KENBOX_2	0.1389
p.L52M	ACH-000997	Colon/Colorectal Cancer	CCLE	KKENG	DEG_APCC_KENBOX_2	0.1389
p.L52M	HCT-15	large_intestine	COSMIC	KKENG	DEG_APCC_KENBOX_2	0.1389
p.E61K	SIDM00118	Colorectal Carcinoma	GDSC	KKENG	DEG_APCC_KENBOX_2	0.7022
p.E61K	HCC2998	large_intestine	COSMIC	KKENG	DEG_APCC_KENBOX_2	0.7022
p.P68T	ACH-000961	Endometrial/Uterine Cancer	CCLE	KKENG	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q0VDF9	Heat shock 70 kDa protein 14	DEG_APCC_KENBOX_2	468:472	KKENG	APC,CDC20,FZR1	0.8284	More...
Q99741	Cell division control protein 6 homolog	DEG_APCC_KENBOX_2	80:84	KKENG	APC,CDC20,FZR1	0.9805	More...
Q9H788	SH2 domain-containing protein 4A	DEG_APCC_KENBOX_2	59:63	KKENG	APC,CDC20,FZR1	0.5489	More...
Q9Y639	Neuroplastin	DEG_APCC_KENBOX_2	273:277	KKENG	APC,CDC20,FZR1	0.5141	More...
Q6PCB5	Lysine-specific demethylase RSBN1L	DEG_APCC_KENBOX_2	223:227	KKENG	APC,CDC20,FZR1	0.7823	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons