DegronMD - Q0VDF9(HSPA14)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R474C	TCGA-AA-3984	COAD	TCGA	KKENG	DEG_APCC_KENBOX_2	468:472	Mutation rewiring degron network	0.2778
p.R474C	TCGA-AN-A0AK	BRCA	TCGA	KKENG	DEG_APCC_KENBOX_2	468:472	Mutation rewiring degron network	0.2778
p.R474C	DO1608	BRCA	ICGC	KKENG	DEG_APCC_KENBOX_2	468:472	Mutation rewiring degron network	0.2778
p.R474C	DO9002	COAD	ICGC	KKENG	DEG_APCC_KENBOX_2	468:472	Mutation rewiring degron network	0.2778
p.A459S	TCGA-B5-A11W	UCEC	TCGA	KKENG	DEG_APCC_KENBOX_2	468:472	Mutation rewiring degron network	0.0833
p.A459S	DO42264	UCEC	ICGC	KKENG	DEG_APCC_KENBOX_2	468:472	Mutation rewiring degron network	0.0833
p.A459V	TCGA-B5-A11W	UCEC	TCGA	KKENG	DEG_APCC_KENBOX_2	468:472	Mutation rewiring degron network	0.0833
p.A459V	DO42264	UCEC	ICGC	KKENG	DEG_APCC_KENBOX_2	468:472	Mutation rewiring degron network	0.0833
p.E470Q	TCGA-UY-A8OD	BLCA	TCGA	KKENG	DEG_APCC_KENBOX_2	468:472	Mutation altering degron motif	0.6744
p.E470Q	DO219039	BLCA	ICGC	KKENG	DEG_APCC_KENBOX_2	468:472	Mutation altering degron motif	0.6744
p.E470Q	SIDM00401	Melanoma	GDSC	KKENG	DEG_APCC_KENBOX_2	468:472	Mutation altering degron motif	0.6744
p.E470Q	ACH-000614	Skin Cancer	CCLE	KKENG	DEG_APCC_KENBOX_2	468:472	Mutation altering degron motif	0.6744
p.E470Q	ACH-002461	Skin Cancer	CCLE	KKENG	DEG_APCC_KENBOX_2	468:472	Mutation altering degron motif	0.6744
p.E470Q	RVH-421	skin	COSMIC	KKENG	DEG_APCC_KENBOX_2	468:472	Mutation altering degron motif	0.6744
p.A478S	DO229045	LICA	ICGC	KKENG	DEG_APCC_KENBOX_2	468:472	Mutation rewiring degron network	0.1667
p.D465N	DO229232	THCA	ICGC	KKENG	DEG_APCC_KENBOX_2	468:472	Mutation rewiring degron network	0.25
p.M482L	SIDM00113	Kidney Carcinoma	GDSC	KKENG	DEG_APCC_KENBOX_2	468:472	Mutation rewiring degron network	0.0556
p.M482L	ACH-001208	Kidney Cancer	CCLE	KKENG	DEG_APCC_KENBOX_2	468:472	Mutation rewiring degron network	0.0556
p.M482L	TK10	kidney	COSMIC	KKENG	DEG_APCC_KENBOX_2	468:472	Mutation rewiring degron network	0.0556
p.I476T	SIDM00282	Colorectal Carcinoma	GDSC	KKENG	DEG_APCC_KENBOX_2	468:472	Mutation rewiring degron network	0.2222
p.I476T	ACH-000998	Colon/Colorectal Cancer	CCLE	KKENG	DEG_APCC_KENBOX_2	468:472	Mutation rewiring degron network	0.2222
p.I476T	CW-2	large intestine	COSMIC	KKENG	DEG_APCC_KENBOX_2	468:472	Mutation rewiring degron network	0.2222

Kaplan plot for HSPA14 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HSPA14

UniProt ID: Q0VDF9

Entrez ID: 51182

Protein name: Heat shock 70 kDa protein 14 (HSP70-like protein 1) (Heat shock protein HSP60)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HSPA14 in