DegronMD - Q9Y639(NPTN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D268E	TCGA-28-1746	GBM	TCGA	KKENG	DEG_APCC_KENBOX_2	273:277	Mutation rewiring degron network	0.1944
p.D268E	DO13564	GBM	ICGC	KKENG	DEG_APCC_KENBOX_2	273:277	Mutation rewiring degron network	0.1944
p.R334Q	TCGA-4Z-AA89	BLCA	TCGA	VRSHLAPLW	DEG_APCC_DBOX_1	333:341	Mutation altering degron motif	0.7329
p.I282V	TCGA-91-A4BD	LUAD	TCGA	KKENG	DEG_APCC_KENBOX_2	273:277	Mutation rewiring degron network	0.1944
p.I282V	DO45315	LUAD	ICGC	KKENG	DEG_APCC_KENBOX_2	273:277	Mutation rewiring degron network	0.1944
p.R288H	TCGA-A5-A0G2	UCEC	TCGA	NKENY	DEG_APCC_KENBOX_2	293:297	Mutation rewiring degron network	0.1944
p.R288H	DO233102	GACA	ICGC	NKENY	DEG_APCC_KENBOX_2	293:297	Mutation rewiring degron network	0.1944
p.R288H	DO41235	UCEC	ICGC	NKENY	DEG_APCC_KENBOX_2	293:297	Mutation rewiring degron network	0.1944
p.P342H	TCGA-AD-6889	COAD	TCGA	VRSHLAPLW	DEG_APCC_DBOX_1	333:341	Mutation rewiring degron network	0.3056
p.R334W	TCGA-B5-A3FC	UCEC	TCGA	VRSHLAPLW	DEG_APCC_DBOX_1	333:341	Mutation altering degron motif	0.8634
p.R272H	TCGA-BR-8591	STAD	TCGA	KKENG	DEG_APCC_KENBOX_2	273:277	Mutation rewiring degron network	0.3056
p.R272H	DO47973	STAD	ICGC	KKENG	DEG_APCC_KENBOX_2	273:277	Mutation rewiring degron network	0.3056
p.T298A	TCGA-DF-A2KZ	UCEC	TCGA	NKENY	DEG_APCC_KENBOX_2	293:297	Mutation rewiring degron network	0.3056
p.T298A	DO52409	UCEC	ICGC	NKENY	DEG_APCC_KENBOX_2	293:297	Mutation rewiring degron network	0.3056
p.P267Q	TCGA-EE-A2GO	SKCM	TCGA	KKENG	DEG_APCC_KENBOX_2	273:277	Mutation rewiring degron network	0.1667
p.P267Q	DO37823	SKCM	ICGC	KKENG	DEG_APCC_KENBOX_2	273:277	Mutation rewiring degron network	0.1667
p.R332M	TCGA-EE-A2M8	SKCM	TCGA	VRSHLAPLW	DEG_APCC_DBOX_1	333:341	Mutation rewiring degron network	0.3056
p.L344F	TCGA-FS-A1Z3	SKCM	TCGA	VRSHLAPLW	DEG_APCC_DBOX_1	333:341	Mutation rewiring degron network	0.25
p.P342L	TCGA-FW-A3R5	SKCM	TCGA	VRSHLAPLW	DEG_APCC_DBOX_1	333:341	Mutation rewiring degron network	0.3056
p.P265R	TCGA-W3-A825	SKCM	TCGA	KKENG	DEG_APCC_KENBOX_2	273:277	Mutation rewiring degron network	0.1111
p.P265R	DO51272	SKCM	ICGC	KKENG	DEG_APCC_KENBOX_2	273:277	Mutation rewiring degron network	0.1111
p.V327A	TCGA-W3-AA1V	SKCM	TCGA	VRSHLAPLW	DEG_APCC_DBOX_1	333:341	Mutation rewiring degron network	0.1667
p.S324C	DO219042	BLCA	ICGC	VRSHLAPLW	DEG_APCC_DBOX_1	333:341	Mutation rewiring degron network	0.0833
p.L326I	DO8463	COAD	ICGC	VRSHLAPLW	DEG_APCC_DBOX_1	333:341	Mutation rewiring degron network	0.1389
p.Q274K	DO229015	LICA	ICGC	KKENG	DEG_APCC_KENBOX_2	273:277	Mutation altering degron motif	0.6944
p.W328L	DO37635	SKCM	ICGC	VRSHLAPLW	DEG_APCC_DBOX_1	333:341	Mutation rewiring degron network	0.1944
p.L326F	DO37406	SKCM	ICGC	VRSHLAPLW	DEG_APCC_DBOX_1	333:341	Mutation rewiring degron network	0.1389
p.K270T	DO41379	UCEC	ICGC	KKENG	DEG_APCC_KENBOX_2	273:277	Mutation rewiring degron network	0.25
p.P279H	SIDM00839	Colorectal Carcinoma	GDSC	KKENG	DEG_APCC_KENBOX_2	273:277	Mutation rewiring degron network	0.2778
p.P279H	ACH-000950	Colon/Colorectal Cancer	CCLE	KKENG	DEG_APCC_KENBOX_2	273:277	Mutation rewiring degron network	0.2778
p.P279H	LoVo	large intestine	COSMIC	KKENG	DEG_APCC_KENBOX_2	273:277	Mutation rewiring degron network	0.2778
p.N266I	THP-1	haematopoietic and lymphoid tissue	COSMIC	KKENG	DEG_APCC_KENBOX_2	273:277	Mutation rewiring degron network	0.1389

Kaplan plot for NPTN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NPTN

UniProt ID: Q9Y639

Entrez ID: 27020

Protein name: Neuroplastin (Stromal cell-derived receptor 1) (SDR-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NPTN in