DegronMD

Uniprot ID: Q9Y639

Source protein: Neuroplastin

Source gene: NPTN

Class: DEG_APCC_DBOX_1

Location: 333:341

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7923

ASA_SCORE: 71.0444

COIL: 0.6969

CONS_SCORE: 0.8495

DSS_SCORE: 0.0039

HELIX: 0.0304

FCONS_SCORE: 1.176

RIG_SCORE: 0.9321

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R334W	TCGA-B5-A3FC	UCEC	TCGA	VRSHLAPLW	DEG_APCC_DBOX_1	0.8634
p.R334Q	TCGA-4Z-AA89	BLCA	TCGA	VRSHLAPLW	DEG_APCC_DBOX_1	0.7329
p.P342H	TCGA-AD-6889	COAD	TCGA	VRSHLAPLW	DEG_APCC_DBOX_1	0.3056
p.R332M	TCGA-EE-A2M8	SKCM	TCGA	VRSHLAPLW	DEG_APCC_DBOX_1	0.3056
p.P342L	TCGA-FW-A3R5	SKCM	TCGA	VRSHLAPLW	DEG_APCC_DBOX_1	0.3056
p.L344F	TCGA-FS-A1Z3	SKCM	TCGA	VRSHLAPLW	DEG_APCC_DBOX_1	0.25
p.W328L	DO37635	SKCM	ICGC	VRSHLAPLW	DEG_APCC_DBOX_1	0.1944
p.V327A	TCGA-W3-AA1V	SKCM	TCGA	VRSHLAPLW	DEG_APCC_DBOX_1	0.1667
p.L326I	DO8463	COAD	ICGC	VRSHLAPLW	DEG_APCC_DBOX_1	0.1389
p.L326F	DO37406	SKCM	ICGC	VRSHLAPLW	DEG_APCC_DBOX_1	0.1389
p.S324C	DO219042	BLCA	ICGC	VRSHLAPLW	DEG_APCC_DBOX_1	0.0833

Showing 1 to 11 of 11 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y639	Neuroplastin	DEG_APCC_DBOX_1	333:341	VRSHLAPLW	APC,CDC20,FZR1	0.7923	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons