DegronMD

Uniprot ID: Q9Y639

Source protein: Neuroplastin

Source gene: NPTN

Class: DEG_APCC_KENBOX_2

Location: 293:297

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6319

ASA_SCORE: 97.3

COIL: 0.568

CONS_SCORE: 0.5266

DSS_SCORE: 0.1096

HELIX: 0.0158

FCONS_SCORE: 0.8691

RIG_SCORE: 0.8672

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R288H	TCGA-A5-A0G2	UCEC	TCGA	NKENY	DEG_APCC_KENBOX_2	0.1944
p.R288H	DO233102	GACA	ICGC	NKENY	DEG_APCC_KENBOX_2	0.1944
p.R288H	DO41235	UCEC	ICGC	NKENY	DEG_APCC_KENBOX_2	0.1944
p.T298A	TCGA-DF-A2KZ	UCEC	TCGA	NKENY	DEG_APCC_KENBOX_2	0.3056
p.T298A	DO52409	UCEC	ICGC	NKENY	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43683	Mitotic checkpoint serine/threonine-protein kinase BUB1	DEG_APCC_KENBOX_2	534:538	NKENY	APC,CDC20,FZR1	0.9657	More...
Q8NE31	Protein FAM13C	DEG_APCC_KENBOX_2	44:48	NKENY	APC,CDC20,FZR1	0.9877	More...
Q9Y639	Neuroplastin	DEG_APCC_KENBOX_2	293:297	NKENY	APC,CDC20,FZR1	0.6319	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons