DegronMD

Uniprot ID: O43683

Source protein: Mitotic checkpoint serine/threonine-protein kinase BUB1

Source gene: BUB1

Class: DEG_APCC_KENBOX_2

Location: 534:538

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9657

ASA_SCORE: 116.42

COIL: 0.8598

CONS_SCORE: 0.2567

DSS_SCORE: 0.511

HELIX: 0.0898

FCONS_SCORE: 0.8972

RIG_SCORE: 0.6726

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G533E	TCGA-06-5416	GBM	TCGA	NKENY	DEG_APCC_KENBOX_2	0.3056
p.G533E	DO10880	GBM	ICGC	NKENY	DEG_APCC_KENBOX_2	0.3056
p.N534S	TCGA-29-2427	OV	TCGA	NKENY	DEG_APCC_KENBOX_2	0.5958
p.N534S	DO31594	OV	ICGC	NKENY	DEG_APCC_KENBOX_2	0.5958
p.N537K	TCGA-A5-A2K5	UCEC	TCGA	NKENY	DEG_APCC_KENBOX_2	0.6918
p.N537K	DO41379	UCEC	ICGC	NKENY	DEG_APCC_KENBOX_2	0.6918
p.E548K	DO474	BLCA	ICGC	NKENY	DEG_APCC_KENBOX_2	0.0556
p.N534D	DO229016	COCA	ICGC	NKENY	DEG_APCC_KENBOX_2	0.5821
p.N534D	DO229005	COCA	ICGC	NKENY	DEG_APCC_KENBOX_2	0.5821
p.N534D	DO230659	LAML	ICGC	NKENY	DEG_APCC_KENBOX_2	0.5821
p.N534D	SIDM00997	Thyroid Gland Carcinoma	GDSC	NKENY	DEG_APCC_KENBOX_2	0.5821
p.N534D	SIDM01210	Glioblastoma	GDSC	NKENY	DEG_APCC_KENBOX_2	0.5821
p.S524P	DO228581	GACA	ICGC	NKENY	DEG_APCC_KENBOX_2	0.0556
p.P547T	DO228976	LICA	ICGC	NKENY	DEG_APCC_KENBOX_2	0.0833
p.P542S	Sarc9371	bone	COSMIC	NKENY	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43683	Mitotic checkpoint serine/threonine-protein kinase BUB1	DEG_APCC_KENBOX_2	534:538	NKENY	APC,CDC20,FZR1	0.9657	More...
Q8NE31	Protein FAM13C	DEG_APCC_KENBOX_2	44:48	NKENY	APC,CDC20,FZR1	0.9877	More...
Q9Y639	Neuroplastin	DEG_APCC_KENBOX_2	293:297	NKENY	APC,CDC20,FZR1	0.6319	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons