DegronMD

Uniprot ID: Q8NE31

Source protein: Protein FAM13C

Source gene: FAM13C

Class: DEG_APCC_KENBOX_2

Location: 44:48

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9877

ASA_SCORE: 89.64

COIL: 0.7616

CONS_SCORE: 0.4677

DSS_SCORE: 0.5929

HELIX: 0.1554

FCONS_SCORE: 1.4059

RIG_SCORE: 0.643

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D50N	TCGA-AP-A1DV	UCEC	TCGA	NKENY	DEG_APCC_KENBOX_2	0.2778
p.D50N	DO43186	UCEC	ICGC	NKENY	DEG_APCC_KENBOX_2	0.2778
p.D41Y	TCGA-EO-A22X	UCEC	TCGA	NKENY	DEG_APCC_KENBOX_2	0.25
p.D41Y	DO43907	UCEC	ICGC	NKENY	DEG_APCC_KENBOX_2	0.25
p.V55I	TCGA-GN-A26C	SKCM	TCGA	NKENY	DEG_APCC_KENBOX_2	0.1389
p.V55I	DO37782	SKCM	ICGC	NKENY	DEG_APCC_KENBOX_2	0.1389
p.L54M	TCGA-IS-A3K8	SARC	TCGA	NKENY	DEG_APCC_KENBOX_2	0.1667
p.L54M	DO220170	SARC	ICGC	NKENY	DEG_APCC_KENBOX_2	0.1667
p.A51T	DO52478	COCA	ICGC	NKENY	DEG_APCC_KENBOX_2	0.25
p.P49S	DO228508	LICA	ICGC	NKENY	DEG_APCC_KENBOX_2	0.3056
p.D35Y	SIDM01310	Esophageal Carcinoma	GDSC	NKENY	DEG_APCC_KENBOX_2	0.0833
p.D35Y	SIDM01311	Esophageal Carcinoma	GDSC	NKENY	DEG_APCC_KENBOX_2	0.0833
p.H58Q	SIDM01183	Other Solid Cancers	GDSC	NKENY	DEG_APCC_KENBOX_2	0.0556
p.H58Q	ACH-001417	Lung Cancer	CCLE	NKENY	DEG_APCC_KENBOX_2	0.0556
p.H58Q	UMC-11	lung	COSMIC	NKENY	DEG_APCC_KENBOX_2	0.0556
p.L39V	ACH-000868	Lung Cancer	CCLE	NKENY	DEG_APCC_KENBOX_2	0.1944
p.N47Y	ACH-001642	Lymphoma	CCLE	NKENY	DEG_APCC_KENBOX_2	0.7059
p.R40T	ECC10	stomach	COSMIC	NKENY	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43683	Mitotic checkpoint serine/threonine-protein kinase BUB1	DEG_APCC_KENBOX_2	534:538	NKENY	APC,CDC20,FZR1	0.9657	More...
Q8NE31	Protein FAM13C	DEG_APCC_KENBOX_2	44:48	NKENY	APC,CDC20,FZR1	0.9877	More...
Q9Y639	Neuroplastin	DEG_APCC_KENBOX_2	293:297	NKENY	APC,CDC20,FZR1	0.6319	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons