DegronMD - Q9H788(SH2D4A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E61D	TCGA-06-5416	GBM	TCGA	KKENG	DEG_APCC_KENBOX_2	59:63	Mutation altering degron motif	0.6758
p.H67Y	TCGA-AJ-A2QM	UCEC	TCGA	KKENG	DEG_APCC_KENBOX_2	59:63	Mutation rewiring degron network	0.2222
p.W68R	TCGA-AJ-A3EK	UCEC	TCGA	KKENG	DEG_APCC_KENBOX_2	59:63	Mutation rewiring degron network	0.1944
p.E64K	DO51948	BLCA	ICGC	KKENG	DEG_APCC_KENBOX_2	59:63	Mutation rewiring degron network	0.3056
p.S73C	DO219076	BLCA	ICGC	KKENG	DEG_APCC_KENBOX_2	59:63	Mutation rewiring degron network	0.0556
p.E55K	DO785	BLCA	ICGC	KKENG	DEG_APCC_KENBOX_2	59:63	Mutation blocking ubiquitination signal	0.6667
p.C49F	DO49058	HNSC	ICGC	KKENG	DEG_APCC_KENBOX_2	59:63	Mutation blocking ubiquitination signal	0.5
p.E64D	DO229036	LICA	ICGC	KKENG	DEG_APCC_KENBOX_2	59:63	Mutation rewiring degron network	0.3056
p.E67D	DO229037	LICA	ICGC	KKENG	DEG_APCC_KENBOX_2	59:63	Mutation rewiring degron network	0.2222
p.R58Q	DO41871	UCEC	ICGC	KKENG	DEG_APCC_KENBOX_2	59:63	Mutation rewiring degron network	0.3056
p.K70T	DO42713	UCEC	ICGC	KKENG	DEG_APCC_KENBOX_2	59:63	Mutation rewiring degron network	0.1389
p.E50K	SIDM01175	Other Sarcomas	GDSC	KKENG	DEG_APCC_KENBOX_2	59:63	Mutation rewiring degron network	0.0833
p.E50K	ACH-002309	Sarcoma	CCLE	KKENG	DEG_APCC_KENBOX_2	59:63	Mutation rewiring degron network	0.0833
p.E50K	SW684	soft tissue	COSMIC	KKENG	DEG_APCC_KENBOX_2	59:63	Mutation rewiring degron network	0.0833
p.L52M	SIDM00789	Colorectal Carcinoma	GDSC	KKENG	DEG_APCC_KENBOX_2	59:63	Mutation rewiring degron network	0.1389
p.L52M	ACH-000997	Colon/Colorectal Cancer	CCLE	KKENG	DEG_APCC_KENBOX_2	59:63	Mutation rewiring degron network	0.1389
p.L52M	HCT-15	large intestine	COSMIC	KKENG	DEG_APCC_KENBOX_2	59:63	Mutation rewiring degron network	0.1389
p.E61K	SIDM00118	Colorectal Carcinoma	GDSC	KKENG	DEG_APCC_KENBOX_2	59:63	Mutation altering degron motif	0.7022
p.E61K	HCC2998	large intestine	COSMIC	KKENG	DEG_APCC_KENBOX_2	59:63	Mutation altering degron motif	0.7022
p.P68T	ACH-000961	Endometrial/Uterine Cancer	CCLE	KKENG	DEG_APCC_KENBOX_2	59:63	Mutation rewiring degron network	0.1944

Kaplan plot for SH2D4A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SH2D4A

UniProt ID: Q9H788

Entrez ID: 63898

Protein name: SH2 domain-containing protein 4A (Protein SH(2)A) (Protein phosphatase 1 regulatory subunit 38)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SH2D4A in