DegronMD - Q99741(CDC6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R445S	TCGA-23-1117	OV	TCGA	KRVGLIHIS	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.0556
p.R445S	DO30830	OV	ICGC	KRVGLIHIS	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.0556
p.K80N	TCGA-66-2768	LUSC	TCGA	KKENG	DEG_APCC_KENBOX_2	80:84	Mutation altering degron motif	0.5806
p.K80N	DO27216	LUSC	ICGC	KKENG	DEG_APCC_KENBOX_2	80:84	Mutation altering degron motif	0.5806
p.D442H	TCGA-A1-A0SN	BRCA	TCGA	KRVGLIHIS	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.1389
p.D442H	DO4299	BRCA	ICGC	KRVGLIHIS	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.1389
p.K92N	TCGA-A5-A1OF	UCEC	TCGA	KKENG	DEG_APCC_KENBOX_2	80:84	Mutation blocking ubiquitination signal	0.5556
p.K92N	DO42568	UCEC	ICGC	KKENG	DEG_APCC_KENBOX_2	80:84	Mutation blocking ubiquitination signal	0.5556
p.R94Q	TCGA-EI-6917	READ	TCGA	KKENG	DEG_APCC_KENBOX_2	80:84	Mutation rewiring degron network	0.0556
p.R94Q	DO36881	READ	ICGC	KKENG	DEG_APCC_KENBOX_2	80:84	Mutation rewiring degron network	0.0556
p.E82Q	TCGA-MP-A4TK	LUAD	TCGA	KKENG	DEG_APCC_KENBOX_2	80:84	Mutation altering degron motif	0.6744
p.E82Q	DO45384	LUAD	ICGC	KKENG	DEG_APCC_KENBOX_2	80:84	Mutation altering degron motif	0.6744
p.H87Q	TCGA-UY-A9PH	BLCA	TCGA	KKENG	DEG_APCC_KENBOX_2	80:84	Mutation rewiring degron network	0.25
p.H87Q	DO223594	BLCA	ICGC	KKENG	DEG_APCC_KENBOX_2	80:84	Mutation rewiring degron network	0.25
p.V441G	DO7801	COAD	ICGC	KRVGLIHIS	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.1667
p.V441I	DO229010	COCA	ICGC	KRVGLIHIS	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.1667
p.V441I	DO229013	COCA	ICGC	KRVGLIHIS	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.1667
p.V441I	DO229016	COCA	ICGC	KRVGLIHIS	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.1667
p.V441I	DO229047	LICA	ICGC	KRVGLIHIS	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.1667
p.V441I	DO52365	LUSC	ICGC	KRVGLIHIS	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.1667
p.V441I	DO231072	LUSC	ICGC	KRVGLIHIS	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.1667
p.V441I	DO231155	LUSC	ICGC	KRVGLIHIS	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.1667
p.H89R	DO233853	GACA	ICGC	KKENG	DEG_APCC_KENBOX_2	80:84	Mutation rewiring degron network	0.1944
p.R445M	DO229019	LICA	ICGC	KRVGLIHIS	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.0556
p.S435P	DO232829	NACA	ICGC	KRVGLIHIS	DEG_APCC_DBOX_1	427:435	Mutation altering degron motif	0.5641
p.V429F	LN-229	central nervous system	COSMIC	KRVGLIHIS	DEG_APCC_DBOX_1	427:435	Mutation altering degron motif	0.5957

Kaplan plot for CDC6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDC6

UniProt ID: Q99741

Entrez ID: 990

Protein name: Cell division control protein 6 homolog (CDC6-related protein) (Cdc18-related protein) (HsCdc18) (p62(cdc6)) (HsCDC6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDC6 in