DegronMD

Uniprot ID: Q99741

Source protein: Cell division control protein 6 homolog

Source gene: CDC6

Class: DEG_APCC_DBOX_1

Location: 427:435

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9773

ASA_SCORE: 57.5889

COIL: 0.3677

CONS_SCORE: 0.4714

DSS_SCORE: 0.2819

HELIX: 0.5687

FCONS_SCORE: 1.3307

RIG_SCORE: 0.7926

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R445S	TCGA-23-1117	OV	TCGA	KRVGLIHIS	DEG_APCC_DBOX_1	0.0556
p.R445S	DO30830	OV	ICGC	KRVGLIHIS	DEG_APCC_DBOX_1	0.0556
p.D442H	TCGA-A1-A0SN	BRCA	TCGA	KRVGLIHIS	DEG_APCC_DBOX_1	0.1389
p.D442H	DO4299	BRCA	ICGC	KRVGLIHIS	DEG_APCC_DBOX_1	0.1389
p.V441G	DO7801	COAD	ICGC	KRVGLIHIS	DEG_APCC_DBOX_1	0.1667
p.V441I	DO229010	COCA	ICGC	KRVGLIHIS	DEG_APCC_DBOX_1	0.1667
p.V441I	DO229013	COCA	ICGC	KRVGLIHIS	DEG_APCC_DBOX_1	0.1667
p.V441I	DO229016	COCA	ICGC	KRVGLIHIS	DEG_APCC_DBOX_1	0.1667
p.V441I	DO229047	LICA	ICGC	KRVGLIHIS	DEG_APCC_DBOX_1	0.1667
p.V441I	DO52365	LUSC	ICGC	KRVGLIHIS	DEG_APCC_DBOX_1	0.1667
p.V441I	DO231072	LUSC	ICGC	KRVGLIHIS	DEG_APCC_DBOX_1	0.1667
p.V441I	DO231155	LUSC	ICGC	KRVGLIHIS	DEG_APCC_DBOX_1	0.1667
p.R445M	DO229019	LICA	ICGC	KRVGLIHIS	DEG_APCC_DBOX_1	0.0556
p.S435P	DO232829	NACA	ICGC	KRVGLIHIS	DEG_APCC_DBOX_1	0.5641
p.V429F	LN-229	central_nervous_system	COSMIC	KRVGLIHIS	DEG_APCC_DBOX_1	0.5957

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99741	Cell division control protein 6 homolog	DEG_APCC_DBOX_1	427:435	KRVGLIHIS	APC,CDC20,FZR1	0.9773	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons