DegronMD

Uniprot ID: Q6PCB5

Source protein: Lysine-specific demethylase RSBN1L

Source gene: RSBN1L

Class: LIG_APCC_ABBAyCdc20_2

Location: 560:566

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8302

ASA_SCORE: 70.7

COIL: 0.3571

CONS_SCORE: 0.7822

DSS_SCORE: 0.541

HELIX: 0.5641

FCONS_SCORE: 1.0983

RIG_SCORE: 0.764

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R560C	TCGA-19-1790	GBM	TCGA	REMLFED	LIG_APCC_ABBAyCdc20_2	0.8301
p.R560C	DO12328	GBM	ICGC	REMLFED	LIG_APCC_ABBAyCdc20_2	0.8301
p.R555Q	TCGA-56-8307	LUSC	TCGA	REMLFED	LIG_APCC_ABBAyCdc20_2	0.1944
p.R555Q	TCGA-AP-A056	UCEC	TCGA	REMLFED	LIG_APCC_ABBAyCdc20_2	0.1944
p.R555Q	TCGA-B5-A3FA	UCEC	TCGA	REMLFED	LIG_APCC_ABBAyCdc20_2	0.1944
p.R555Q	DO219139	LUSC	ICGC	REMLFED	LIG_APCC_ABBAyCdc20_2	0.1944
p.R555Q	DO52402	UCEC	ICGC	REMLFED	LIG_APCC_ABBAyCdc20_2	0.1944
p.R555Q	DO43971	UCEC	ICGC	REMLFED	LIG_APCC_ABBAyCdc20_2	0.1944
p.H571Y	TCGA-FW-A3R5	SKCM	TCGA	REMLFED	LIG_APCC_ABBAyCdc20_2	0.1944
p.H571Y	DO37406	SKCM	ICGC	REMLFED	LIG_APCC_ABBAyCdc20_2	0.1944
p.T568A	DO222762	COCA	ICGC	REMLFED	LIG_APCC_ABBAyCdc20_2	0.2778
p.R569T	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	REMLFED	LIG_APCC_ABBAyCdc20_2	0.25
p.R569T	ACH-000893	Lung Cancer	CCLE	REMLFED	LIG_APCC_ABBAyCdc20_2	0.25
p.R569T	NCI-H1651	lung	COSMIC	REMLFED	LIG_APCC_ABBAyCdc20_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PCB5	Lysine-specific demethylase RSBN1L	LIG_APCC_ABBAyCdc20_2	560:566	REMLFED	APC,CDC20,FZR1	0.8302	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons