DegronMD

Uniprot ID: Q96L91

Source protein: E1A-binding protein p400

Source gene: EP400

Class: DEG_SCF_FBW7_1

Location: 2663:2669

E3 ligase: FBXW7

DEGRON score: 0.9982

ASA_SCORE: 76.0429

COIL: 0.8699

CONS_SCORE: 0.3725

DSS_SCORE: 0.5338

HELIX: 0.016

FCONS_SCORE: 1.11

RIG_SCORE: 0.5867

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V2679I	TCGA-24-1845	OV	TCGA	LTTPGGS	DEG_SCF_FBW7_1	0.0556
p.S2660F	TCGA-D9-A6EC	SKCM	TCGA	LTTPGGS	DEG_SCF_FBW7_1	0.25
p.V2660M	DO233941	GACA	ICGC	LTTPGGS	DEG_SCF_FBW7_1	0.25
p.V2666F	DO228976	LICA	ICGC	LTTPGGS	DEG_SCF_FBW7_1	0.7068
p.T2664S	DO45390	LUAD	ICGC	LTTPGGS	DEG_SCF_FBW7_1	0.6005
p.T2663M	SIDM00958	Chronic Myelogenous Leukemia	GDSC	LTTPGGS	DEG_SCF_FBW7_1	0.7423
p.T2663M	SIDM00847	Rhabdomyosarcoma	GDSC	LTTPGGS	DEG_SCF_FBW7_1	0.7423
p.T2663M	ACH-000169	Sarcoma	CCLE	LTTPGGS	DEG_SCF_FBW7_1	0.7423
p.T2663M	ACH-000920	Leukemia	CCLE	LTTPGGS	DEG_SCF_FBW7_1	0.7423
p.T2663M	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	LTTPGGS	DEG_SCF_FBW7_1	0.7423
p.T2663M	RD	soft_tissue	COSMIC	LTTPGGS	DEG_SCF_FBW7_1	0.7423
p.A2654V	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	LTTPGGS	DEG_SCF_FBW7_1	0.0833
p.V2678M	ACH-000954	Endometrial/Uterine Cancer	CCLE	LTTPGGS	DEG_SCF_FBW7_1	0.0833
p.A2662V	ACH-000997	Colon/Colorectal Cancer	CCLE	LTTPGGS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96L91	E1A-binding protein p400	DEG_SCF_FBW7_1	2663:2669	LTTPGGS	FBXW7	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons