DegronMD

Uniprot ID: Q5MJ09

Source protein: Sperm protein associated with the nucleus on the X chromosome N3

Source gene: SPANXN3

Class: DEG_SPOP_SBC_1

Location: 4:8

E3 ligase: SPOP

DEGRON score: 0.9373

ASA_SCORE: 89.46

COIL: 0.9278

CONS_SCORE: 0.9707

DSS_SCORE: 0.9222

HELIX: 0.0556

FCONS_SCORE: 1.1148

RIG_SCORE: 0.5694

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S15T	TCGA-44-2668	LUAD	TCGA	PTSST	DEG_SPOP_SBC_1	0.1389
p.S15T	DO25232	LUAD	ICGC	PTSST	DEG_SPOP_SBC_1	0.1389
p.T5N	TCGA-44-A4SU	LUAD	TCGA	PTSST	DEG_SPOP_SBC_1	0.5944
p.T5N	TCGA-OR-A5L2	ACC	TCGA	PTSST	DEG_SPOP_SBC_1	0.5944
p.T5N	DO24507	LUAD	ICGC	PTSST	DEG_SPOP_SBC_1	0.5944
p.T13A	TCGA-55-5899	LUAD	TCGA	PTSST	DEG_SPOP_SBC_1	0.1944
p.T13A	DO26042	LUAD	ICGC	PTSST	DEG_SPOP_SBC_1	0.1944
p.T13S	TCGA-BR-4292	STAD	TCGA	PTSST	DEG_SPOP_SBC_1	0.1944
p.T13S	DO38495	STAD	ICGC	PTSST	DEG_SPOP_SBC_1	0.1944
p.S6F	TCGA-EE-A2MD	SKCM	TCGA	PTSST	DEG_SPOP_SBC_1	0.7982
p.S6F	DO222434	MELA	ICGC	PTSST	DEG_SPOP_SBC_1	0.7982
p.S6F	DO37851	SKCM	ICGC	PTSST	DEG_SPOP_SBC_1	0.7982
p.P4L	TCGA-EE-A3J5	SKCM	TCGA	PTSST	DEG_SPOP_SBC_1	0.7582
p.P4L	DO47331	SKCM	ICGC	PTSST	DEG_SPOP_SBC_1	0.7582
p.S15N	TCGA-EO-A22R	UCEC	TCGA	PTSST	DEG_SPOP_SBC_1	0.1389
p.S15N	DO42713	UCEC	ICGC	PTSST	DEG_SPOP_SBC_1	0.1389
p.E18K	TCGA-L5-A43C	ESCA	TCGA	PTSST	DEG_SPOP_SBC_1	0.0556
p.E18K	SIDM00193	Colorectal Carcinoma	GDSC	PTSST	DEG_SPOP_SBC_1	0.0556
p.E18K	ACH-000991	Colon/Colorectal Cancer	CCLE	PTSST	DEG_SPOP_SBC_1	0.0556
p.E18K	SNU-81	large_intestine	COSMIC	PTSST	DEG_SPOP_SBC_1	0.0556
p.G10V	TCGA-OR-A5KB	ACC	TCGA	PTSST	DEG_SPOP_SBC_1	0.2778
p.S7C	DO225002	BRCA	ICGC	PTSST	DEG_SPOP_SBC_1	0.7541
p.S7R	DO229009	LICA	ICGC	PTSST	DEG_SPOP_SBC_1	0.7427
p.P16S	SIDM00453	Pancreatic Carcinoma	GDSC	PTSST	DEG_SPOP_SBC_1	0.1111
p.P16S	ACH-000023	Pancreatic Cancer	CCLE	PTSST	DEG_SPOP_SBC_1	0.1111
p.P16S	PA-TU-8988T	pancreas	COSMIC	PTSST	DEG_SPOP_SBC_1	0.1111
p.S6P	SIDM01045	Endometrial Carcinoma	GDSC	PTSST	DEG_SPOP_SBC_1	0.6752
p.S6P	ACH-000978	Endometrial/Uterine Cancer	CCLE	PTSST	DEG_SPOP_SBC_1	0.6752
p.S6P	EN	endometrium	COSMIC	PTSST	DEG_SPOP_SBC_1	0.6752
p.E18D	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	PTSST	DEG_SPOP_SBC_1	0.0556
p.E18D	ACH-001362	Lung Cancer	CCLE	PTSST	DEG_SPOP_SBC_1	0.0556
p.E18D	NCI-H1770	lung	COSMIC	PTSST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14523	Phospholipid transfer protein C2CD2L	DEG_SPOP_SBC_1	418:422	PTSST	SPOP	0.9786	More...
P15336	Cyclic AMP-dependent transcription factor ATF-2	DEG_SPOP_SBC_1	192:196	PTSST	SPOP	0.99	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3040:3044	PTSST	SPOP	0.6013	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4197:4201	PTSST	SPOP	0.7113	More...
Q00587	Cdc42 effector protein 1	DEG_SPOP_SBC_1	144:148	PTSST	SPOP	0.9968	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1289:1293	PTSST	SPOP	0.8909	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	2061:2065	PTSST	SPOP	0.7841	More...
Q5MJ10	Sperm protein associated with the nucleus on the X chromosome N2	DEG_SPOP_SBC_1	4:8	PTSST	SPOP	0.9481	More...
Q6NW40	Repulsive guidance molecule B	DEG_SPOP_SBC_1	126:130	PTSST	SPOP	0.901	More...
Q6XYQ8	Synaptotagmin-10	DEG_SPOP_SBC_1	165:169	PTSST	SPOP	0.9752	More...
Q71F56	Mediator of RNA polymerase II transcription subunit 13-like	DEG_SPOP_SBC_1	2000:2004	PTSST	SPOP	0.8758	More...
Q7Z2Z1	Treslin	DEG_SPOP_SBC_1	352:356	PTSST	SPOP	0.7312	More...
Q7Z5J4	Retinoic acid-induced protein 1	DEG_SPOP_SBC_1	217:221	PTSST	SPOP	0.9896	More...
Q8IUR6	CREB3 regulatory factor	DEG_SPOP_SBC_1	207:211	PTSST	SPOP	0.9783	More...
Q8N302	Angiogenic factor with G patch and FHA domains 1	DEG_SPOP_SBC_1	262:266	PTSST	SPOP	0.9756	More...
Q8WZ74	Cortactin-binding protein 2	DEG_SPOP_SBC_1	394:398	PTSST	SPOP	0.9594	More...
Q96L91	E1A-binding protein p400	DEG_SPOP_SBC_1	699:703	PTSST	SPOP	0.7029	More...
Q9HCM3	UPF0606 protein KIAA1549	DEG_SPOP_SBC_1	1911:1915	PTSST	SPOP	0.9958	More...
Q9ULH7	Myocardin-related transcription factor B	DEG_SPOP_SBC_1	544:548	PTSST	SPOP	0.9796	More...
Q9UNA1	Rho GTPase-activating protein 26	DEG_SPOP_SBC_1	688:692	PTSST	SPOP	0.7165	More...
Q9Y2R2	Tyrosine-protein phosphatase non-receptor type 22	DEG_SPOP_SBC_1	568:572	PTSST	SPOP	0.6888	More...
Q9Y613	FH1/FH2 domain-containing protein 1	DEG_SPOP_SBC_1	391:395	PTSST	SPOP	0.8673	More...
A6NFR6	Uncharacterized protein C5orf60	DEG_SPOP_SBC_1	220:224	PTSST	SPOP	0.9363	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2086:2090	PTSST	SPOP	0.6316	More...
Q5MJ09	Sperm protein associated with the nucleus on the X chromosome N3	DEG_SPOP_SBC_1	4:8	PTSST	SPOP	0.9373	More...
Q5MJ07	Sperm protein associated with the nucleus on the X chromosome N5	DEG_SPOP_SBC_1	4:8	PTSST	SPOP	0.6951	More...
Q5MJ08	Sperm protein associated with the nucleus on the X chromosome N4	DEG_SPOP_SBC_1	4:8	PTSST	SPOP	0.9627	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTSST

Degron related mutations and impact score

Drug responses associated with SPANXN3 mutations

All proteins holding degron of PTSST