DegronMD - A6NFR6(C5orf60)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L192M	TCGA-3X-AAVB	CHOL	TCGA	PREPLCPLK	DEG_APCC_DBOX_1	197:205	Mutation rewiring degron network	0.1944
p.A213V	TCGA-AA-A00N	COAD	TCGA	PREPLCPLK	DEG_APCC_DBOX_1	197:205	Mutation rewiring degron network	0.1111
p.A213V	TCGA-AA-A00N	COAD	TCGA	PTSST	DEG_SPOP_SBC_1	220:224	Mutation rewiring degron network	0.1389
p.A213V	DO9876	COAD	ICGC	PREPLCPLK	DEG_APCC_DBOX_1	197:205	Mutation rewiring degron network	0.1111
p.A213V	DO9876	COAD	ICGC	PTSST	DEG_SPOP_SBC_1	220:224	Mutation rewiring degron network	0.1389
p.S195C	TCGA-AN-A0AT	BRCA	TCGA	PREPLCPLK	DEG_APCC_DBOX_1	197:205	Mutation rewiring degron network	0.2778
p.S195C	DO2783	BRCA	ICGC	PREPLCPLK	DEG_APCC_DBOX_1	197:205	Mutation rewiring degron network	0.2778
p.S222G	TCGA-AP-A0LM	UCEC	TCGA	PTSST	DEG_SPOP_SBC_1	220:224	Mutation altering degron motif	0.6993
p.S222G	DO43306	UCEC	ICGC	PTSST	DEG_SPOP_SBC_1	220:224	Mutation altering degron motif	0.6993
p.S188Y	TCGA-AP-A0LM	UCEC	TCGA	PREPLCPLK	DEG_APCC_DBOX_1	197:205	Mutation rewiring degron network	0.0833
p.S188Y	DO43306	UCEC	ICGC	PREPLCPLK	DEG_APCC_DBOX_1	197:205	Mutation rewiring degron network	0.0833
p.H209D	TCGA-DD-AADG	LIHC	TCGA	PREPLCPLK	DEG_APCC_DBOX_1	197:205	Mutation rewiring degron network	0.2222
p.H209D	DO219571	LIHC	ICGC	PREPLCPLK	DEG_APCC_DBOX_1	197:205	Mutation rewiring degron network	0.2222
p.R198Q	TCGA-EC-A24G	UCEC	TCGA	PREPLCPLK	DEG_APCC_DBOX_1	197:205	Mutation altering degron motif	0.7329
p.R198Q	DO40996	UCEC	ICGC	PREPLCPLK	DEG_APCC_DBOX_1	197:205	Mutation altering degron motif	0.7329
p.R198Q	ACH-000666	Lung Cancer	CCLE	PREPLCPLK	DEG_APCC_DBOX_1	197:205	Mutation altering degron motif	0.7329
p.S194Y	TCGA-OR-A5KB	ACC	TCGA	PREPLCPLK	DEG_APCC_DBOX_1	197:205	Mutation rewiring degron network	0.25
p.S214N	DO229010	COCA	ICGC	PREPLCPLK	DEG_APCC_DBOX_1	197:205	Mutation rewiring degron network	0.0833
p.S214N	DO229010	COCA	ICGC	PTSST	DEG_SPOP_SBC_1	220:224	Mutation rewiring degron network	0.1667
p.S214N	DO229005	COCA	ICGC	PREPLCPLK	DEG_APCC_DBOX_1	197:205	Mutation rewiring degron network	0.0833
p.S214N	DO229005	COCA	ICGC	PTSST	DEG_SPOP_SBC_1	220:224	Mutation rewiring degron network	0.1667
p.S214N	DO230659	LAML	ICGC	PREPLCPLK	DEG_APCC_DBOX_1	197:205	Mutation rewiring degron network	0.0833
p.S214N	DO230659	LAML	ICGC	PTSST	DEG_SPOP_SBC_1	220:224	Mutation rewiring degron network	0.1667
p.S214N	DO225404	LAML	ICGC	PREPLCPLK	DEG_APCC_DBOX_1	197:205	Mutation rewiring degron network	0.0833
p.S214N	DO225404	LAML	ICGC	PTSST	DEG_SPOP_SBC_1	220:224	Mutation rewiring degron network	0.1667
p.S214N	DO231140	LAML	ICGC	PREPLCPLK	DEG_APCC_DBOX_1	197:205	Mutation rewiring degron network	0.0833
p.S214N	DO231140	LAML	ICGC	PTSST	DEG_SPOP_SBC_1	220:224	Mutation rewiring degron network	0.1667
p.P189A	DO48234	ESCA	ICGC	PREPLCPLK	DEG_APCC_DBOX_1	197:205	Mutation rewiring degron network	0.1111
p.G228W	DO48234	ESCA	ICGC	PTSST	DEG_SPOP_SBC_1	220:224	Mutation rewiring degron network	0.2222
p.L227F	DO229019	LICA	ICGC	PTSST	DEG_SPOP_SBC_1	220:224	Mutation rewiring degron network	0.25
p.S191F	DO229058	LICA	ICGC	PREPLCPLK	DEG_APCC_DBOX_1	197:205	Mutation rewiring degron network	0.1667
p.L168P	DO231070	LUSC	ICGC	PRAPLAPLA	DEG_APCC_DBOX_1	164:172	Mutation altering degron motif	0.7582
p.A172V	DO220899	MELA	ICGC	PRAPLAPLA	DEG_APCC_DBOX_1	164:172	Mutation altering degron motif	0.5825
p.S191T	DO222708	MELA	ICGC	PREPLCPLK	DEG_APCC_DBOX_1	197:205	Mutation rewiring degron network	0.1667
p.P207H	DO41578	UCEC	ICGC	PREPLCPLK	DEG_APCC_DBOX_1	197:205	Mutation rewiring degron network	0.2778
p.A169S	ACH-001373	Ovarian Cancer	CCLE	PRAPLAPLA	DEG_APCC_DBOX_1	164:172	Mutation altering degron motif	0.6477

DegronMD: protein-targeted degradation, mutation and drug response to degrons

C5orf60

UniProt ID: A6NFR6

Entrez ID: 285679

Protein name: Uncharacterized protein C5orf60

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for C5orf60 in