DegronMD

Uniprot ID: A6NFR6

Source protein: Uncharacterized protein C5orf60

Source gene: C5orf60

Class: DEG_APCC_DBOX_1

Location: 197:205

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9594

ASA_SCORE: 89.6889

COIL: 0.9431

CONS_SCORE: 0.8507

DSS_SCORE: 0.7129

HELIX: 0.0227

FCONS_SCORE: 1.1883

RIG_SCORE: 0.5772

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L192M	TCGA-3X-AAVB	CHOL	TCGA	PREPLCPLK	DEG_APCC_DBOX_1	0.1944
p.A213V	TCGA-AA-A00N	COAD	TCGA	PREPLCPLK	DEG_APCC_DBOX_1	0.1111
p.A213V	DO9876	COAD	ICGC	PREPLCPLK	DEG_APCC_DBOX_1	0.1111
p.S195C	TCGA-AN-A0AT	BRCA	TCGA	PREPLCPLK	DEG_APCC_DBOX_1	0.2778
p.S195C	DO2783	BRCA	ICGC	PREPLCPLK	DEG_APCC_DBOX_1	0.2778
p.S188Y	TCGA-AP-A0LM	UCEC	TCGA	PREPLCPLK	DEG_APCC_DBOX_1	0.0833
p.S188Y	DO43306	UCEC	ICGC	PREPLCPLK	DEG_APCC_DBOX_1	0.0833
p.H209D	TCGA-DD-AADG	LIHC	TCGA	PREPLCPLK	DEG_APCC_DBOX_1	0.2222
p.H209D	DO219571	LIHC	ICGC	PREPLCPLK	DEG_APCC_DBOX_1	0.2222
p.R198Q	TCGA-EC-A24G	UCEC	TCGA	PREPLCPLK	DEG_APCC_DBOX_1	0.7329
p.R198Q	DO40996	UCEC	ICGC	PREPLCPLK	DEG_APCC_DBOX_1	0.7329
p.R198Q	ACH-000666	Lung Cancer	CCLE	PREPLCPLK	DEG_APCC_DBOX_1	0.7329
p.S194Y	TCGA-OR-A5KB	ACC	TCGA	PREPLCPLK	DEG_APCC_DBOX_1	0.25
p.S214N	DO229010	COCA	ICGC	PREPLCPLK	DEG_APCC_DBOX_1	0.0833
p.S214N	DO229005	COCA	ICGC	PREPLCPLK	DEG_APCC_DBOX_1	0.0833
p.S214N	DO230659	LAML	ICGC	PREPLCPLK	DEG_APCC_DBOX_1	0.0833
p.S214N	DO225404	LAML	ICGC	PREPLCPLK	DEG_APCC_DBOX_1	0.0833
p.S214N	DO231140	LAML	ICGC	PREPLCPLK	DEG_APCC_DBOX_1	0.0833
p.P189A	DO48234	ESCA	ICGC	PREPLCPLK	DEG_APCC_DBOX_1	0.1111
p.S191F	DO229058	LICA	ICGC	PREPLCPLK	DEG_APCC_DBOX_1	0.1667
p.S191T	DO222708	MELA	ICGC	PREPLCPLK	DEG_APCC_DBOX_1	0.1667
p.P207H	DO41578	UCEC	ICGC	PREPLCPLK	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NFR6	Uncharacterized protein C5orf60	DEG_APCC_DBOX_1	197:205	PREPLCPLK	APC,CDC20,FZR1	0.9594	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons