DegronMD

Uniprot ID: A6NFR6

Source protein: Uncharacterized protein C5orf60

Source gene: C5orf60

Class: DEG_APCC_DBOX_1

Location: 164:172

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9993

ASA_SCORE: 75.1889

COIL: 0.8556

CONS_SCORE: 0.8607

DSS_SCORE: 0.5634

HELIX: 0.1233

FCONS_SCORE: 1.4355

RIG_SCORE: 0.6498

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L168P	DO231070	LUSC	ICGC	PRAPLAPLA	DEG_APCC_DBOX_1	0.7582
p.A172V	DO220899	MELA	ICGC	PRAPLAPLA	DEG_APCC_DBOX_1	0.5825
p.A169S	ACH-001373	Ovarian Cancer	CCLE	PRAPLAPLA	DEG_APCC_DBOX_1	0.6477

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NFR6	Uncharacterized protein C5orf60	DEG_APCC_DBOX_1	164:172	PRAPLAPLA	APC,CDC20,FZR1	0.9993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons