DegronMD

Uniprot ID: Q9HCM3

Source protein: UPF0606 protein KIAA1549

Source gene: KIAA1549

Class: DEG_SPOP_SBC_1

Location: 1911:1915

E3 ligase: SPOP

DEGRON score: 0.9958

ASA_SCORE: 71.38

COIL: 0.8698

CONS_SCORE: 0.4895

DSS_SCORE: 0.7357

HELIX: 0.1088

FCONS_SCORE: 1.0397

RIG_SCORE: 0.6174

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1906T	TCGA-A6-3809	COAD	TCGA	PTSST	DEG_SPOP_SBC_1	0.1944
p.P1906T	DO8722	COAD	ICGC	PTSST	DEG_SPOP_SBC_1	0.1944
p.P1906T	SIDM00596	Endometrial Carcinoma	GDSC	PTSST	DEG_SPOP_SBC_1	0.1944
p.P1906T	ACH-001517	Endometrial/Uterine Cancer	CCLE	PTSST	DEG_SPOP_SBC_1	0.1944
p.P1906T	HEC-1	endometrium	COSMIC	PTSST	DEG_SPOP_SBC_1	0.1944
p.Q1919K	TCGA-EC-A24G	UCEC	TCGA	PTSST	DEG_SPOP_SBC_1	0.2222
p.Q1919K	DO40996	UCEC	ICGC	PTSST	DEG_SPOP_SBC_1	0.2222
p.S1914F	TCGA-EE-A2MD	SKCM	TCGA	PTSST	DEG_SPOP_SBC_1	0.7982
p.S1914F	DO37851	SKCM	ICGC	PTSST	DEG_SPOP_SBC_1	0.7982
p.G1905S	TCGA-N7-A4Y0	UCS	TCGA	PTSST	DEG_SPOP_SBC_1	0.1667
p.R1901W	DO233645	GACA	ICGC	PTSST	DEG_SPOP_SBC_1	0.0556
p.R1901W	SIDM02026	Colorectal Carcinoma	GDSC	PTSST	DEG_SPOP_SBC_1	0.0556
p.S1913C	DO228827	LICA	ICGC	PTSST	DEG_SPOP_SBC_1	0.7541
p.T1912N	DO229025	LICA	ICGC	PTSST	DEG_SPOP_SBC_1	0.7055
p.E1916K	DO230940	LUSC	ICGC	PTSST	DEG_SPOP_SBC_1	0.3056
p.E1916K	DO224584	LUSC	ICGC	PTSST	DEG_SPOP_SBC_1	0.3056
p.R1901Q	SIDM01259	B-Lymphoblastic Leukemia	GDSC	PTSST	DEG_SPOP_SBC_1	0.0556
p.R1901Q	ACH-001669	Leukemia	CCLE	PTSST	DEG_SPOP_SBC_1	0.0556
p.R1901Q	ACH-002238	Leukemia	CCLE	PTSST	DEG_SPOP_SBC_1	0.0556
p.R1901Q	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	PTSST	DEG_SPOP_SBC_1	0.0556
p.G1921V	SIDM01146	Gastric Carcinoma	GDSC	PTSST	DEG_SPOP_SBC_1	0.1667
p.G1921V	ACH-000932	Gastric Cancer	CCLE	PTSST	DEG_SPOP_SBC_1	0.1667
p.G1921V	NCI-SNU-1	stomach	COSMIC	PTSST	DEG_SPOP_SBC_1	0.1667
p.S1924L	SIDM00485	Oral Cavity Carcinoma	GDSC	PTSST	DEG_SPOP_SBC_1	0.0833
p.S1924L	ACH-000794	Head and Neck Cancer	CCLE	PTSST	DEG_SPOP_SBC_1	0.0833
p.S1924L	BICR22	upper_aerodigestive_tract	COSMIC	PTSST	DEG_SPOP_SBC_1	0.0833
p.P1906R	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTSST	DEG_SPOP_SBC_1	0.1944
p.P1906R	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	PTSST	DEG_SPOP_SBC_1	0.1944
p.P1906S	ACH-000591	Brain Cancer	CCLE	PTSST	DEG_SPOP_SBC_1	0.1944
p.G1921D	ACH-001719	Ovarian Cancer	CCLE	PTSST	DEG_SPOP_SBC_1	0.1667
p.G1905V	NCI-SNU-1	stomach	COSMIC	PTSST	DEG_SPOP_SBC_1	0.1667
p.S1908L	BICR22	upper_aerodigestive_tract	COSMIC	PTSST	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14523	Phospholipid transfer protein C2CD2L	DEG_SPOP_SBC_1	418:422	PTSST	SPOP	0.9786	More...
P15336	Cyclic AMP-dependent transcription factor ATF-2	DEG_SPOP_SBC_1	192:196	PTSST	SPOP	0.99	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3040:3044	PTSST	SPOP	0.6013	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4197:4201	PTSST	SPOP	0.7113	More...
Q00587	Cdc42 effector protein 1	DEG_SPOP_SBC_1	144:148	PTSST	SPOP	0.9968	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1289:1293	PTSST	SPOP	0.8909	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	2061:2065	PTSST	SPOP	0.7841	More...
Q5MJ10	Sperm protein associated with the nucleus on the X chromosome N2	DEG_SPOP_SBC_1	4:8	PTSST	SPOP	0.9481	More...
Q6NW40	Repulsive guidance molecule B	DEG_SPOP_SBC_1	126:130	PTSST	SPOP	0.901	More...
Q6XYQ8	Synaptotagmin-10	DEG_SPOP_SBC_1	165:169	PTSST	SPOP	0.9752	More...
Q71F56	Mediator of RNA polymerase II transcription subunit 13-like	DEG_SPOP_SBC_1	2000:2004	PTSST	SPOP	0.8758	More...
Q7Z2Z1	Treslin	DEG_SPOP_SBC_1	352:356	PTSST	SPOP	0.7312	More...
Q7Z5J4	Retinoic acid-induced protein 1	DEG_SPOP_SBC_1	217:221	PTSST	SPOP	0.9896	More...
Q8IUR6	CREB3 regulatory factor	DEG_SPOP_SBC_1	207:211	PTSST	SPOP	0.9783	More...
Q8N302	Angiogenic factor with G patch and FHA domains 1	DEG_SPOP_SBC_1	262:266	PTSST	SPOP	0.9756	More...
Q8WZ74	Cortactin-binding protein 2	DEG_SPOP_SBC_1	394:398	PTSST	SPOP	0.9594	More...
Q96L91	E1A-binding protein p400	DEG_SPOP_SBC_1	699:703	PTSST	SPOP	0.7029	More...
Q9HCM3	UPF0606 protein KIAA1549	DEG_SPOP_SBC_1	1911:1915	PTSST	SPOP	0.9958	More...
Q9ULH7	Myocardin-related transcription factor B	DEG_SPOP_SBC_1	544:548	PTSST	SPOP	0.9796	More...
Q9UNA1	Rho GTPase-activating protein 26	DEG_SPOP_SBC_1	688:692	PTSST	SPOP	0.7165	More...
Q9Y2R2	Tyrosine-protein phosphatase non-receptor type 22	DEG_SPOP_SBC_1	568:572	PTSST	SPOP	0.6888	More...
Q9Y613	FH1/FH2 domain-containing protein 1	DEG_SPOP_SBC_1	391:395	PTSST	SPOP	0.8673	More...
A6NFR6	Uncharacterized protein C5orf60	DEG_SPOP_SBC_1	220:224	PTSST	SPOP	0.9363	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2086:2090	PTSST	SPOP	0.6316	More...
Q5MJ09	Sperm protein associated with the nucleus on the X chromosome N3	DEG_SPOP_SBC_1	4:8	PTSST	SPOP	0.9373	More...
Q5MJ07	Sperm protein associated with the nucleus on the X chromosome N5	DEG_SPOP_SBC_1	4:8	PTSST	SPOP	0.6951	More...
Q5MJ08	Sperm protein associated with the nucleus on the X chromosome N4	DEG_SPOP_SBC_1	4:8	PTSST	SPOP	0.9627	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTSST

Degron related mutations and impact score

Drug responses associated with KIAA1549 mutations

All proteins holding degron of PTSST