DegronMD - Q8N302(AGGF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N621S	TCGA-58-A46N	LUSC	TCGA	GRKMLEKMG	DEG_APCC_DBOX_1	623:631	Mutation rewiring degron network	0.2778
p.N621S	DO45460	LUSC	ICGC	GRKMLEKMG	DEG_APCC_DBOX_1	623:631	Mutation rewiring degron network	0.2778
p.E636Q	TCGA-A8-A06Q	BRCA	TCGA	GRKMLEKMG	DEG_APCC_DBOX_1	623:631	Mutation rewiring degron network	0.1944
p.E636Q	DO1263	BRCA	ICGC	GRKMLEKMG	DEG_APCC_DBOX_1	623:631	Mutation rewiring degron network	0.1944
p.L258F	TCGA-AX-A2HG	UCEC	TCGA	PTSST	DEG_SPOP_SBC_1	262:266	Mutation rewiring degron network	0.2222
p.L258F	DO41337	UCEC	ICGC	PTSST	DEG_SPOP_SBC_1	262:266	Mutation rewiring degron network	0.2222
p.R255Q	TCGA-B6-A0IH	BRCA	TCGA	PTSST	DEG_SPOP_SBC_1	262:266	Mutation rewiring degron network	0.1389
p.R255Q	DO2749	BRCA	ICGC	PTSST	DEG_SPOP_SBC_1	262:266	Mutation rewiring degron network	0.1389
p.P260T	TCGA-CI-6624	READ	TCGA	PTSST	DEG_SPOP_SBC_1	262:266	Mutation rewiring degron network	0.2778
p.P260T	DO37130	READ	ICGC	PTSST	DEG_SPOP_SBC_1	262:266	Mutation rewiring degron network	0.2778
p.K276N	TCGA-QS-A5YQ	UCEC	TCGA	PTSST	DEG_SPOP_SBC_1	262:266	Mutation substituting flanking lysine	0.1667
p.K276N	DO49073	UCEC	ICGC	PTSST	DEG_SPOP_SBC_1	262:266	Mutation substituting flanking lysine	0.1667
p.R624W	TCGA-Z2-A8RT	SKCM	TCGA	GRKMLEKMG	DEG_APCC_DBOX_1	623:631	Mutation altering degron motif	0.8634
p.R624W	DO51301	SKCM	ICGC	GRKMLEKMG	DEG_APCC_DBOX_1	623:631	Mutation altering degron motif	0.8634
p.M630K	DO229060	LICA	ICGC	GRKMLEKMG	DEG_APCC_DBOX_1	623:631	Mutation altering degron motif	0.8062
p.H614Y	DO220851	MELA	ICGC	GRKMLEKMG	DEG_APCC_DBOX_1	623:631	Mutation rewiring degron network	0.0833
p.P260A	SIDM00957	Colorectal Carcinoma	GDSC	PTSST	DEG_SPOP_SBC_1	262:266	Mutation rewiring degron network	0.2778
p.P260A	ACH-000350	Colon/Colorectal Cancer	CCLE	PTSST	DEG_SPOP_SBC_1	262:266	Mutation rewiring degron network	0.2778
p.P260A	COLO-678	large intestine	COSMIC	PTSST	DEG_SPOP_SBC_1	262:266	Mutation rewiring degron network	0.2778
p.P262L	ACH-001786	Colon/Colorectal Cancer	CCLE	PTSST	DEG_SPOP_SBC_1	262:266	Mutation altering degron motif	0.7582

Kaplan plot for AGGF1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AGGF1

UniProt ID: Q8N302

Entrez ID: 55109

Protein name: Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (hVG5Q) (G patch domain-containing protein 7) (Vasculogenesis gene on 5q protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AGGF1 in