DegronMD

Uniprot ID: Q8N302

Source protein: Angiogenic factor with G patch and FHA domains 1

Source gene: AGGF1

Class: DEG_APCC_DBOX_1

Location: 623:631

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8491

ASA_SCORE: 60.0778

COIL: 0.2214

CONS_SCORE: 0.6743

DSS_SCORE: 0.5578

HELIX: 0.7762

FCONS_SCORE: 1.0464

RIG_SCORE: 0.7284

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N621S	TCGA-58-A46N	LUSC	TCGA	GRKMLEKMG	DEG_APCC_DBOX_1	0.2778
p.N621S	DO45460	LUSC	ICGC	GRKMLEKMG	DEG_APCC_DBOX_1	0.2778
p.E636Q	TCGA-A8-A06Q	BRCA	TCGA	GRKMLEKMG	DEG_APCC_DBOX_1	0.1944
p.E636Q	DO1263	BRCA	ICGC	GRKMLEKMG	DEG_APCC_DBOX_1	0.1944
p.R624W	TCGA-Z2-A8RT	SKCM	TCGA	GRKMLEKMG	DEG_APCC_DBOX_1	0.8634
p.R624W	DO51301	SKCM	ICGC	GRKMLEKMG	DEG_APCC_DBOX_1	0.8634
p.M630K	DO229060	LICA	ICGC	GRKMLEKMG	DEG_APCC_DBOX_1	0.8062
p.H614Y	DO220851	MELA	ICGC	GRKMLEKMG	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N302	Angiogenic factor with G patch and FHA domains 1	DEG_APCC_DBOX_1	623:631	GRKMLEKMG	APC,CDC20,FZR1	0.8491	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons