DegronMD - O14523(C2CD2L)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R294W	TCGA-06-5416	GBM	TCGA	NRLFLRQLR	DEG_APCC_DBOX_1	286:294	Mutation altering degron motif	0.7523
p.Q292H	TCGA-23-1116	OV	TCGA	NRLFLRQLR	DEG_APCC_DBOX_1	286:294	Mutation altering degron motif	0.647
p.R284T	TCGA-2F-A9KO	BLCA	TCGA	NRLFLRQLR	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.2778
p.P371S	TCGA-37-4132	LUSC	TCGA	SRRQLCPLT	DEG_APCC_DBOX_1	380:388	Mutation rewiring degron network	0.0833
p.S374F	TCGA-44-7662	LUAD	TCGA	SRRQLCPLT	DEG_APCC_DBOX_1	380:388	Mutation blocking phosphorylation signal	0.6111
p.R381Q	TCGA-A6-2686	COAD	TCGA	SRRQLCPLT	DEG_APCC_DBOX_1	380:388	Mutation altering degron motif	0.7329
p.R287Q	TCGA-AJ-A3EK	UCEC	TCGA	NRLFLRQLR	DEG_APCC_DBOX_1	286:294	Mutation altering degron motif	0.7329
p.L415M	TCGA-B5-A11E	UCEC	TCGA	LGTPTSS	DEG_SCF_FBW7_1	415:421	Mutation altering degron motif	0.5999
p.Q277H	TCGA-BR-4257	STAD	TCGA	NRLFLRQLR	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.0833
p.P412H	TCGA-DZ-6132	KIRP	TCGA	LGTPTSS	DEG_SCF_FBW7_1	415:421	Mutation rewiring degron network	0.25
p.P412H	TCGA-DZ-6132	KIRP	TCGA	PTSST	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.1667
p.P412H	TCGA-DZ-6132	KIRP	TCGA	VELHYE	LIG_APCC_ABBA_1	403:408	Mutation rewiring degron network	0.2222
p.P389T	TCGA-EE-A17Z	SKCM	TCGA	SRRQLCPLT	DEG_APCC_DBOX_1	380:388	Mutation rewiring degron network	0.3056
p.R424C	TCGA-HU-8243	STAD	TCGA	LGTPTSS	DEG_SCF_FBW7_1	415:421	Mutation rewiring degron network	0.25
p.R424C	TCGA-HU-8243	STAD	TCGA	PTSST	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.2778
p.I282T	TCGA-HU-8602	STAD	TCGA	NRLFLRQLR	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.2222
p.L387F	TCGA-W5-AA39	CHOL	TCGA	SRRQLCPLT	DEG_APCC_DBOX_1	380:388	Mutation altering degron motif	0.6981
p.Y407C	TCGA-ZF-A9R0	BLCA	TCGA	VELHYE	LIG_APCC_ABBA_1	403:408	Mutation altering degron motif	0.5976
p.Q294E	DO223594	BLCA	ICGC	NRLFLRQLR	DEG_APCC_DBOX_1	286:294	Mutation altering degron motif	0.6744
p.T281S	DO3164	BRCA	ICGC	NRLFLRQLR	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.1944
p.S285F	DO51607	CESC	ICGC	NRLFLRQLR	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.3056
p.A304V	DO50650	KIRC	ICGC	NRLFLRQLR	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.0556
p.A304V	ACH-000446	Neuroblastoma	CCLE	NRLFLRQLR	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.0556
p.A304V	ACH-000734	Liver Cancer	CCLE	NRLFLRQLR	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.0556
p.A304V	ACH-000947	Ovarian Cancer	CCLE	NRLFLRQLR	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.0556
p.A304V	OVK-18	ovary	COSMIC	NRLFLRQLR	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.0556
p.L282F	DO23654	LUAD	ICGC	NRLFLRQLR	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.2222
p.E296K	DO228451	MALY	ICGC	NRLFLRQLR	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.2778
p.A304T	DO232224	PBCA	ICGC	NRLFLRQLR	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.0556
p.H383Y	DO219454	SKCM	ICGC	SRRQLCPLT	DEG_APCC_DBOX_1	380:388	Mutation altering degron motif	0.7229
p.R279C	DO41752	UCEC	ICGC	NRLFLRQLR	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.1389
p.P375T	SIDM02026	Colorectal Carcinoma	GDSC	SRRQLCPLT	DEG_APCC_DBOX_1	380:388	Mutation rewiring degron network	0.1944
p.E409A	SIDM01290	Esophageal Carcinoma	GDSC	LGTPTSS	DEG_SCF_FBW7_1	415:421	Mutation rewiring degron network	0.1667
p.E409A	SIDM01290	Esophageal Carcinoma	GDSC	PTSST	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.0833
p.E409A	SIDM01290	Esophageal Carcinoma	GDSC	VELHYE	LIG_APCC_ABBA_1	403:408	Mutation rewiring degron network	0.3056
p.T422N	SIDM00572	Gastric Carcinoma	GDSC	PTSST	DEG_SPOP_SBC_1	418:422	Mutation altering degron motif	0.8166
p.T422N	NUGC-3	stomach	COSMIC	PTSST	DEG_SPOP_SBC_1	418:422	Mutation altering degron motif	0.8166
p.T388I	SIDM01194	Hepatocellular Carcinoma	GDSC	SRRQLCPLT	DEG_APCC_DBOX_1	380:388	Mutation altering degron motif	0.7078
p.T388I	SNU-449	liver	COSMIC	SRRQLCPLT	DEG_APCC_DBOX_1	380:388	Mutation altering degron motif	0.7078
p.L299V	ACH-000223	Breast Cancer	CCLE	NRLFLRQLR	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.1944
p.L299V	HCC1937	breast	COSMIC	NRLFLRQLR	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.1944
p.R279H	ACH-000338	Lymphoma	CCLE	NRLFLRQLR	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.1389
p.R279G	ACH-001409	Bladder Cancer	CCLE	NRLFLRQLR	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.1389
p.L297V	ACH-001607	Gallbladder Cancer	CCLE	NRLFLRQLR	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.25

Kaplan plot for C2CD2L in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

C2CD2L

UniProt ID: O14523

Entrez ID: 9854

Protein name: Phospholipid transfer protein C2CD2L (C2 domain-containing protein 2-like) (C2CD2-like) (Transmembrane protein 24)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for C2CD2L in