DegronMD

Uniprot ID: O14523

Source protein: Phospholipid transfer protein C2CD2L

Source gene: C2CD2L

Class: DEG_APCC_DBOX_1

Location: 380:388

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9696

ASA_SCORE: 70.3667

COIL: 0.4796

CONS_SCORE: 0.5449

DSS_SCORE: 0.6051

HELIX: 0.0099

FCONS_SCORE: 1.0898

RIG_SCORE: 0.7054

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P371S	TCGA-37-4132	LUSC	TCGA	SRRQLCPLT	DEG_APCC_DBOX_1	0.0833
p.S374F	TCGA-44-7662	LUAD	TCGA	SRRQLCPLT	DEG_APCC_DBOX_1	0.6111
p.R381Q	TCGA-A6-2686	COAD	TCGA	SRRQLCPLT	DEG_APCC_DBOX_1	0.7329
p.P389T	TCGA-EE-A17Z	SKCM	TCGA	SRRQLCPLT	DEG_APCC_DBOX_1	0.3056
p.L387F	TCGA-W5-AA39	CHOL	TCGA	SRRQLCPLT	DEG_APCC_DBOX_1	0.6981
p.H383Y	DO219454	SKCM	ICGC	SRRQLCPLT	DEG_APCC_DBOX_1	0.7229
p.P375T	SIDM02026	Colorectal Carcinoma	GDSC	SRRQLCPLT	DEG_APCC_DBOX_1	0.1944
p.T388I	SIDM01194	Hepatocellular Carcinoma	GDSC	SRRQLCPLT	DEG_APCC_DBOX_1	0.7078
p.T388I	SNU-449	liver	COSMIC	SRRQLCPLT	DEG_APCC_DBOX_1	0.7078

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14523	Phospholipid transfer protein C2CD2L	DEG_APCC_DBOX_1	380:388	SRRQLCPLT	APC,CDC20,FZR1	0.9696	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons