DegronMD

Uniprot ID: O14523

Source protein: Phospholipid transfer protein C2CD2L

Source gene: C2CD2L

Class: DEG_SCF_FBW7_1

Location: 415:421

E3 ligase: FBXW7

DEGRON score: 0.9879

ASA_SCORE: 74.2429

COIL: 0.9446

CONS_SCORE: 0.4493

DSS_SCORE: 0.7471

HELIX: 0.0286

FCONS_SCORE: 0.7636

RIG_SCORE: 0.576

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L415M	TCGA-B5-A11E	UCEC	TCGA	LGTPTSS	DEG_SCF_FBW7_1	0.5999
p.P412H	TCGA-DZ-6132	KIRP	TCGA	LGTPTSS	DEG_SCF_FBW7_1	0.25
p.R424C	TCGA-HU-8243	STAD	TCGA	LGTPTSS	DEG_SCF_FBW7_1	0.25
p.E409A	SIDM01290	Esophageal Carcinoma	GDSC	LGTPTSS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14523	Phospholipid transfer protein C2CD2L	DEG_SCF_FBW7_1	415:421	LGTPTSS	FBXW7	0.9879	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons