DegronMD

Uniprot ID: O14523

Source protein: Phospholipid transfer protein C2CD2L

Source gene: C2CD2L

Class: DEG_APCC_DBOX_1

Location: 286:294

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7185

ASA_SCORE: 67.2889

COIL: 0.1594

CONS_SCORE: 0.3747

DSS_SCORE: 0.4229

HELIX: 0.0083

FCONS_SCORE: 1.2212

RIG_SCORE: 0.7849

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R294W	TCGA-06-5416	GBM	TCGA	NRLFLRQLR	DEG_APCC_DBOX_1	0.7523
p.Q292H	TCGA-23-1116	OV	TCGA	NRLFLRQLR	DEG_APCC_DBOX_1	0.647
p.R284T	TCGA-2F-A9KO	BLCA	TCGA	NRLFLRQLR	DEG_APCC_DBOX_1	0.2778
p.R287Q	TCGA-AJ-A3EK	UCEC	TCGA	NRLFLRQLR	DEG_APCC_DBOX_1	0.7329
p.Q277H	TCGA-BR-4257	STAD	TCGA	NRLFLRQLR	DEG_APCC_DBOX_1	0.0833
p.I282T	TCGA-HU-8602	STAD	TCGA	NRLFLRQLR	DEG_APCC_DBOX_1	0.2222
p.Q294E	DO223594	BLCA	ICGC	NRLFLRQLR	DEG_APCC_DBOX_1	0.6744
p.T281S	DO3164	BRCA	ICGC	NRLFLRQLR	DEG_APCC_DBOX_1	0.1944
p.S285F	DO51607	CESC	ICGC	NRLFLRQLR	DEG_APCC_DBOX_1	0.3056
p.A304V	DO50650	KIRC	ICGC	NRLFLRQLR	DEG_APCC_DBOX_1	0.0556
p.A304V	ACH-000446	Neuroblastoma	CCLE	NRLFLRQLR	DEG_APCC_DBOX_1	0.0556
p.A304V	ACH-000734	Liver Cancer	CCLE	NRLFLRQLR	DEG_APCC_DBOX_1	0.0556
p.A304V	ACH-000947	Ovarian Cancer	CCLE	NRLFLRQLR	DEG_APCC_DBOX_1	0.0556
p.A304V	OVK-18	ovary	COSMIC	NRLFLRQLR	DEG_APCC_DBOX_1	0.0556
p.L282F	DO23654	LUAD	ICGC	NRLFLRQLR	DEG_APCC_DBOX_1	0.2222
p.E296K	DO228451	MALY	ICGC	NRLFLRQLR	DEG_APCC_DBOX_1	0.2778
p.A304T	DO232224	PBCA	ICGC	NRLFLRQLR	DEG_APCC_DBOX_1	0.0556
p.R279C	DO41752	UCEC	ICGC	NRLFLRQLR	DEG_APCC_DBOX_1	0.1389
p.L299V	ACH-000223	Breast Cancer	CCLE	NRLFLRQLR	DEG_APCC_DBOX_1	0.1944
p.L299V	HCC1937	breast	COSMIC	NRLFLRQLR	DEG_APCC_DBOX_1	0.1944
p.R279H	ACH-000338	Lymphoma	CCLE	NRLFLRQLR	DEG_APCC_DBOX_1	0.1389
p.R279G	ACH-001409	Bladder Cancer	CCLE	NRLFLRQLR	DEG_APCC_DBOX_1	0.1389
p.L297V	ACH-001607	Gallbladder Cancer	CCLE	NRLFLRQLR	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14523	Phospholipid transfer protein C2CD2L	DEG_APCC_DBOX_1	286:294	NRLFLRQLR	APC,CDC20,FZR1	0.7185	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons