DegronMD - Q7Z5J4(RAI1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E491V	TCGA-12-0818	GBM	TCGA	PSSTPQST	DEG_SCF_FBW7_1	501:508	Mutation rewiring degron network	0.0556
p.E491V	TCGA-12-0818	GBM	TCGA	PAGTPLSE	DEG_SCF_FBW7_2	492:499	Mutation rewiring degron network	0.3056
p.E491V	TCGA-12-0818	GBM	TCGA	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.0833
p.E491V	DO12892	GBM	ICGC	PSSTPQST	DEG_SCF_FBW7_1	501:508	Mutation rewiring degron network	0.0556
p.E491V	DO12892	GBM	ICGC	PAGTPLSE	DEG_SCF_FBW7_2	492:499	Mutation rewiring degron network	0.3056
p.E491V	DO12892	GBM	ICGC	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.0833
p.S1656F	TCGA-90-A4ED	LUSC	TCGA	PLSST	DEG_SPOP_SBC_1	1665:1669	Mutation rewiring degron network	0.0833
p.S1656F	DO45482	LUSC	ICGC	PLSST	DEG_SPOP_SBC_1	1665:1669	Mutation rewiring degron network	0.0833
p.P1674S	TCGA-A5-A0G1	UCEC	TCGA	PLSST	DEG_SPOP_SBC_1	1665:1669	Mutation rewiring degron network	0.1944
p.P1674S	DO42472	UCEC	ICGC	PLSST	DEG_SPOP_SBC_1	1665:1669	Mutation rewiring degron network	0.1944
p.Q211R	TCGA-CD-A4MI	STAD	TCGA	PTSST	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.1667
p.Q211R	DO47717	STAD	ICGC	PTSST	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.1667
p.A1631T	TCGA-CH-5769	PRAD	TCGA	ASSSS	DEG_SPOP_SBC_1	1631:1635	Mutation altering degron motif	0.7139
p.A1631T	DO36245	PRAD	ICGC	ASSSS	DEG_SPOP_SBC_1	1631:1635	Mutation altering degron motif	0.7139
p.S482R	TCGA-CM-6674	COAD	TCGA	PAGTPLSE	DEG_SCF_FBW7_2	492:499	Mutation rewiring degron network	0.0556
p.S482R	DO10092	COAD	ICGC	PAGTPLSE	DEG_SCF_FBW7_2	492:499	Mutation rewiring degron network	0.0556
p.T221I	TCGA-CV-7413	HNSC	TCGA	PTSST	DEG_SPOP_SBC_1	217:221	Mutation altering degron motif	0.7078
p.T221I	DO15567	HNSC	ICGC	PTSST	DEG_SPOP_SBC_1	217:221	Mutation altering degron motif	0.7078
p.G1655C	TCGA-D1-A103	UCEC	TCGA	PLSST	DEG_SPOP_SBC_1	1665:1669	Mutation rewiring degron network	0.0556
p.G1655C	DO42312	UCEC	ICGC	PLSST	DEG_SPOP_SBC_1	1665:1669	Mutation rewiring degron network	0.0556
p.S1628F	TCGA-D3-A2JE	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	1631:1635	Mutation rewiring degron network	0.25
p.S1628F	DO219476	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	1631:1635	Mutation rewiring degron network	0.25
p.S1628F	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	1631:1635	Mutation rewiring degron network	0.25
p.S1628F	ACH-000726	Esophageal Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	1631:1635	Mutation rewiring degron network	0.25
p.S1632F	TCGA-D3-A5GO	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	1631:1635	Mutation altering degron motif	0.6871
p.S1632F	DO47419	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	1631:1635	Mutation altering degron motif	0.6871
p.P217S	TCGA-EB-A5UL	SKCM	TCGA	PTSST	DEG_SPOP_SBC_1	217:221	Mutation altering degron motif	0.6752
p.P217S	DO47601	SKCM	ICGC	PTSST	DEG_SPOP_SBC_1	217:221	Mutation altering degron motif	0.6752
p.P483H	TCGA-EE-A2M8	SKCM	TCGA	PAGTPLSE	DEG_SCF_FBW7_2	492:499	Mutation rewiring degron network	0.0833
p.P483H	DO222404	BTCA	ICGC	PAGTPLSE	DEG_SCF_FBW7_2	492:499	Mutation rewiring degron network	0.0833
p.P483H	DO38075	SKCM	ICGC	PAGTPLSE	DEG_SCF_FBW7_2	492:499	Mutation rewiring degron network	0.0833
p.A1631V	TCGA-EY-A548	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	1631:1635	Mutation altering degron motif	0.5825
p.A1631V	DO48173	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	1631:1635	Mutation altering degron motif	0.5825
p.A493T	TCGA-EY-A549	UCEC	TCGA	PAGTPLSE	DEG_SCF_FBW7_2	492:499	Mutation altering degron motif	0.6028
p.A493T	DO48174	UCEC	ICGC	PAGTPLSE	DEG_SCF_FBW7_2	492:499	Mutation altering degron motif	0.6028
p.S1632P	TCGA-W3-AA21	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	1631:1635	Mutation altering degron motif	0.5641
p.S1632P	DO51278	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	1631:1635	Mutation altering degron motif	0.5641
p.S1630C	TCGA-YC-A8S6	BLCA	TCGA	ASSSS	DEG_SPOP_SBC_1	1631:1635	Mutation rewiring degron network	0.3056
p.S1630C	DO49806	BLCA	ICGC	ASSSS	DEG_SPOP_SBC_1	1631:1635	Mutation rewiring degron network	0.3056
p.F216L	DO218173	BRCA	ICGC	PTSST	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.3056
p.R1630H	DO222454	BTCA	ICGC	ASSSS	DEG_SPOP_SBC_1	1631:1635	Mutation rewiring degron network	0.3056
p.R1630H	DO41871	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	1631:1635	Mutation rewiring degron network	0.3056
p.T1669M	DO222794	COCA	ICGC	PLSST	DEG_SPOP_SBC_1	1665:1669	Mutation altering degron motif	0.7423
p.R1621Q	DO233267	GACA	ICGC	ASSSS	DEG_SPOP_SBC_1	1631:1635	Mutation rewiring degron network	0.0556
p.L1642V	DO233814	GACA	ICGC	ASSSS	DEG_SPOP_SBC_1	1631:1635	Mutation rewiring degron network	0.1389
p.S503I	DO228948	LICA	ICGC	PSSTPQST	DEG_SCF_FBW7_1	501:508	Mutation altering degron motif	0.623
p.S503I	DO228948	LICA	ICGC	PPSST	DEG_SPOP_SBC_1	500:504	Mutation altering degron motif	0.7341
p.D1628Y	DO228952	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	1631:1635	Mutation rewiring degron network	0.25
p.M1670I	DO229031	LICA	ICGC	PLSST	DEG_SPOP_SBC_1	1665:1669	Mutation rewiring degron network	0.3056
p.Q1639H	DO229031	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	1631:1635	Mutation rewiring degron network	0.2222
p.A1634S	DO229031	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	1631:1635	Mutation altering degron motif	0.7588
p.S507C	DO229141	LMS	ICGC	PSSTPQST	DEG_SCF_FBW7_1	501:508	Mutation altering degron motif	0.643
p.D1643N	DO220861	MELA	ICGC	ASSSS	DEG_SPOP_SBC_1	1631:1635	Mutation rewiring degron network	0.1111
p.P1621A	DO229143	NKTL	ICGC	ASSSS	DEG_SPOP_SBC_1	1631:1635	Mutation rewiring degron network	0.0556
p.E491K	DO51501	PACA	ICGC	PSSTPQST	DEG_SCF_FBW7_1	501:508	Mutation rewiring degron network	0.0556
p.E491K	DO51501	PACA	ICGC	PAGTPLSE	DEG_SCF_FBW7_2	492:499	Mutation rewiring degron network	0.3056
p.E491K	DO51501	PACA	ICGC	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.0833
p.C1624Y	DO229446	SKCA	ICGC	ASSSS	DEG_SPOP_SBC_1	1631:1635	Mutation rewiring degron network	0.1389
p.R1629H	DO42504	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	1631:1635	Mutation rewiring degron network	0.2778
p.E511K	SIDM00399	Head and Neck Carcinoma	GDSC	PSSTPQST	DEG_SCF_FBW7_1	501:508	Mutation rewiring degron network	0.25
p.E511K	SIDM00399	Head and Neck Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.1389
p.E511K	SCC90	upper aerodigestive tract	COSMIC	PSSTPQST	DEG_SCF_FBW7_1	501:508	Mutation rewiring degron network	0.25
p.E511K	SCC90	upper aerodigestive tract	COSMIC	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.1389
p.S502R	SIDM01233	Colorectal Carcinoma	GDSC	PSSTPQST	DEG_SCF_FBW7_1	501:508	Mutation altering degron motif	0.6316
p.S502R	SIDM01233	Colorectal Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	500:504	Mutation altering degron motif	0.7427
p.S502R	ACH-000003		CCLE	PSSTPQST	DEG_SCF_FBW7_1	501:508	Mutation altering degron motif	0.6316
p.S502R	ACH-000003		CCLE	PPSST	DEG_SPOP_SBC_1	500:504	Mutation altering degron motif	0.7427
p.S502R	ACH-000009	Colon/Colorectal Cancer	CCLE	PSSTPQST	DEG_SCF_FBW7_1	501:508	Mutation altering degron motif	0.6316
p.S502R	ACH-000009	Colon/Colorectal Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	500:504	Mutation altering degron motif	0.7427
p.S502R	C2BBe1	large intestine	COSMIC	PSSTPQST	DEG_SCF_FBW7_1	501:508	Mutation altering degron motif	0.6316
p.S502R	C2BBe1	large intestine	COSMIC	PPSST	DEG_SPOP_SBC_1	500:504	Mutation altering degron motif	0.7427
p.Q513R	SIDM00277	Acute Myeloid Leukemia	GDSC	PSSTPQST	DEG_SCF_FBW7_1	501:508	Mutation rewiring degron network	0.1944
p.Q513R	SIDM00277	Acute Myeloid Leukemia	GDSC	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.0833
p.T221A	SIDM00799	Glioblastoma	GDSC	PTSST	DEG_SPOP_SBC_1	217:221	Mutation altering degron motif	0.7139
p.T221A	ACH-000558	Brain Cancer	CCLE	PTSST	DEG_SPOP_SBC_1	217:221	Mutation altering degron motif	0.7139
p.T221A	A172	central nervous system	COSMIC	PTSST	DEG_SPOP_SBC_1	217:221	Mutation altering degron motif	0.7139
p.D1643H	SIDM00833	Colorectal Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	1631:1635	Mutation rewiring degron network	0.1111
p.D1643H	ACH-000421	Colon/Colorectal Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	1631:1635	Mutation rewiring degron network	0.1111
p.D1643H	SW837	large intestine	COSMIC	ASSSS	DEG_SPOP_SBC_1	1631:1635	Mutation rewiring degron network	0.1111
p.S1637L	SIDM00345	Non-Small Cell Lung Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	1631:1635	Mutation rewiring degron network	0.2778
p.S1637L	LCLC-103H	lung	COSMIC	ASSSS	DEG_SPOP_SBC_1	1631:1635	Mutation rewiring degron network	0.2778
p.Y517C	SIDM00498	Colorectal Carcinoma	GDSC	PSSTPQST	DEG_SCF_FBW7_1	501:508	Mutation blocking phosphorylation signal	0.5278
p.Y517C	ACH-000970	Colon/Colorectal Cancer	CCLE	PSSTPQST	DEG_SCF_FBW7_1	501:508	Mutation blocking phosphorylation signal	0.5278
p.Y517C	SNU-C5	large intestine	COSMIC	PSSTPQST	DEG_SCF_FBW7_1	501:508	Mutation blocking phosphorylation signal	0.5278
p.T504M	SIDM01051	Ovarian Carcinoma	GDSC	PSSTPQST	DEG_SCF_FBW7_1	501:508	Mutation altering degron motif	0.7423
p.T504M	SIDM01051	Ovarian Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	500:504	Mutation altering degron motif	0.7423
p.T504M	ACH-000936	Ovarian Cancer	CCLE	PSSTPQST	DEG_SCF_FBW7_1	501:508	Mutation altering degron motif	0.7423
p.T504M	ACH-000936	Ovarian Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	500:504	Mutation altering degron motif	0.7423
p.T504M	EFO-27	ovary	COSMIC	PSSTPQST	DEG_SCF_FBW7_1	501:508	Mutation altering degron motif	0.7423
p.T504M	EFO-27	ovary	COSMIC	PPSST	DEG_SPOP_SBC_1	500:504	Mutation altering degron motif	0.7423
p.R1625K	SIDM00118	Colorectal Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	1631:1635	Mutation rewiring degron network	0.1667
p.R1625K	ACH-001081	Colon/Colorectal Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	1631:1635	Mutation rewiring degron network	0.1667
p.R1625K	HCC2998	large intestine	COSMIC	ASSSS	DEG_SPOP_SBC_1	1631:1635	Mutation rewiring degron network	0.1667
p.L1658M	SIDM01617	Endometrial Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	1665:1669	Mutation rewiring degron network	0.1389
p.S219F	ACH-002785	Unknown	CCLE	PTSST	DEG_SPOP_SBC_1	217:221	Mutation altering degron motif	0.7982
p.G211D	LCLC-97TM1	lung	COSMIC	PTSST	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.1667
p.T1659A	EN	endometrium	COSMIC	PLSST	DEG_SPOP_SBC_1	1665:1669	Mutation rewiring degron network	0.1667
p.D226E	H2810	pleura	COSMIC	PTSST	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.1944
p.A493V	SNU-1040	large intestine	COSMIC	PAGTPLSE	DEG_SCF_FBW7_2	492:499	Mutation altering degron motif	0.5825
p.T218I	NCI-H1341	lung	COSMIC	PTSST	DEG_SPOP_SBC_1	217:221	Mutation altering degron motif	0.5966
p.R1658C	SNU-C2B	large intestine	COSMIC	PLSST	DEG_SPOP_SBC_1	1665:1669	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RAI1

UniProt ID: Q7Z5J4

Entrez ID: 10743

Protein name: Retinoic acid-induced protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RAI1 in