DegronMD

Uniprot ID: Q7Z5J4

Source protein: Retinoic acid-induced protein 1

Source gene: RAI1

Class: DEG_SCF_FBW7_2

Location: 492:499

E3 ligase: FBXW7

DEGRON score: 0.9754

ASA_SCORE: 92.1125

COIL: 0.955

CONS_SCORE: 0.6329

DSS_SCORE: 0.8205

HELIX: 0.0161

FCONS_SCORE: 1.0925

RIG_SCORE: 0.5134

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E491V	TCGA-12-0818	GBM	TCGA	PAGTPLSE	DEG_SCF_FBW7_2	0.3056
p.E491V	DO12892	GBM	ICGC	PAGTPLSE	DEG_SCF_FBW7_2	0.3056
p.S482R	TCGA-CM-6674	COAD	TCGA	PAGTPLSE	DEG_SCF_FBW7_2	0.0556
p.S482R	DO10092	COAD	ICGC	PAGTPLSE	DEG_SCF_FBW7_2	0.0556
p.P483H	TCGA-EE-A2M8	SKCM	TCGA	PAGTPLSE	DEG_SCF_FBW7_2	0.0833
p.P483H	DO222404	BTCA	ICGC	PAGTPLSE	DEG_SCF_FBW7_2	0.0833
p.P483H	DO38075	SKCM	ICGC	PAGTPLSE	DEG_SCF_FBW7_2	0.0833
p.A493T	TCGA-EY-A549	UCEC	TCGA	PAGTPLSE	DEG_SCF_FBW7_2	0.6028
p.A493T	DO48174	UCEC	ICGC	PAGTPLSE	DEG_SCF_FBW7_2	0.6028
p.E491K	DO51501	PACA	ICGC	PAGTPLSE	DEG_SCF_FBW7_2	0.3056
p.A493V	SNU-1040	large_intestine	COSMIC	PAGTPLSE	DEG_SCF_FBW7_2	0.5825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z5J4	Retinoic acid-induced protein 1	DEG_SCF_FBW7_2	492:499	PAGTPLSE	FBXW7	0.9754	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons