DegronMD

Uniprot ID: Q7Z5J4

Source protein: Retinoic acid-induced protein 1

Source gene: RAI1

Class: DEG_SCF_FBW7_1

Location: 501:508

E3 ligase: FBXW7

DEGRON score: 0.8836

ASA_SCORE: 94.4125

COIL: 0.9539

CONS_SCORE: 0.6239

DSS_SCORE: 0.8557

HELIX: 0.0209

FCONS_SCORE: 1.0067

RIG_SCORE: 0.505

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E491V	TCGA-12-0818	GBM	TCGA	PSSTPQST	DEG_SCF_FBW7_1	0.0556
p.E491V	DO12892	GBM	ICGC	PSSTPQST	DEG_SCF_FBW7_1	0.0556
p.S503I	DO228948	LICA	ICGC	PSSTPQST	DEG_SCF_FBW7_1	0.623
p.S507C	DO229141	LMS	ICGC	PSSTPQST	DEG_SCF_FBW7_1	0.643
p.E491K	DO51501	PACA	ICGC	PSSTPQST	DEG_SCF_FBW7_1	0.0556
p.E511K	SIDM00399	Head and Neck Carcinoma	GDSC	PSSTPQST	DEG_SCF_FBW7_1	0.25
p.E511K	SCC90	upper_aerodigestive_tract	COSMIC	PSSTPQST	DEG_SCF_FBW7_1	0.25
p.S502R	SIDM01233	Colorectal Carcinoma	GDSC	PSSTPQST	DEG_SCF_FBW7_1	0.6316
p.S502R	ACH-000003		CCLE	PSSTPQST	DEG_SCF_FBW7_1	0.6316
p.S502R	ACH-000009	Colon/Colorectal Cancer	CCLE	PSSTPQST	DEG_SCF_FBW7_1	0.6316
p.S502R	C2BBe1	large_intestine	COSMIC	PSSTPQST	DEG_SCF_FBW7_1	0.6316
p.Q513R	SIDM00277	Acute Myeloid Leukemia	GDSC	PSSTPQST	DEG_SCF_FBW7_1	0.1944
p.Y517C	SIDM00498	Colorectal Carcinoma	GDSC	PSSTPQST	DEG_SCF_FBW7_1	0.5278
p.Y517C	ACH-000970	Colon/Colorectal Cancer	CCLE	PSSTPQST	DEG_SCF_FBW7_1	0.5278
p.Y517C	SNU-C5	large_intestine	COSMIC	PSSTPQST	DEG_SCF_FBW7_1	0.5278
p.T504M	SIDM01051	Ovarian Carcinoma	GDSC	PSSTPQST	DEG_SCF_FBW7_1	0.7423
p.T504M	ACH-000936	Ovarian Cancer	CCLE	PSSTPQST	DEG_SCF_FBW7_1	0.7423
p.T504M	EFO-27	ovary	COSMIC	PSSTPQST	DEG_SCF_FBW7_1	0.7423

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z5J4	Retinoic acid-induced protein 1	DEG_SCF_FBW7_1	501:508	PSSTPQST	FBXW7	0.8836	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons