DegronMD - Q7Z2Z1(TICRR)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1131L	TCGA-3B-A9HT	SARC	TCGA	PQTPLYT	DEG_SCF_FBW7_1	1128:1134	Mutation altering degron motif	0.7582
p.P1131L	TCGA-BH-A0H5	BRCA	TCGA	PQTPLYT	DEG_SCF_FBW7_1	1128:1134	Mutation altering degron motif	0.7582
p.P1131L	TCGA-IB-7651	PAAD	TCGA	PQTPLYT	DEG_SCF_FBW7_1	1128:1134	Mutation altering degron motif	0.7582
p.P1131L	DO5207	BRCA	ICGC	PQTPLYT	DEG_SCF_FBW7_1	1128:1134	Mutation altering degron motif	0.7582
p.P1131L	DO46657	PAAD	ICGC	PQTPLYT	DEG_SCF_FBW7_1	1128:1134	Mutation altering degron motif	0.7582
p.P1131L	DO219934	SARC	ICGC	PQTPLYT	DEG_SCF_FBW7_1	1128:1134	Mutation altering degron motif	0.7582
p.R884T	TCGA-4Z-AA7Q	BLCA	TCGA	KKENS	DEG_APCC_KENBOX_2	887:891	Mutation rewiring degron network	0.25
p.R884T	DO218980	BLCA	ICGC	KKENS	DEG_APCC_KENBOX_2	887:891	Mutation rewiring degron network	0.25
p.P1121A	TCGA-55-A491	LUAD	TCGA	PQTPLYT	DEG_SCF_FBW7_1	1128:1134	Mutation rewiring degron network	0.1389
p.P1121A	DO25787	LUAD	ICGC	PQTPLYT	DEG_SCF_FBW7_1	1128:1134	Mutation rewiring degron network	0.1389
p.P1121A	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	PQTPLYT	DEG_SCF_FBW7_1	1128:1134	Mutation rewiring degron network	0.1389
p.P1121A	ACH-000727	Lung Cancer	CCLE	PQTPLYT	DEG_SCF_FBW7_1	1128:1134	Mutation rewiring degron network	0.1389
p.P1121A	NCI-H2066	lung	COSMIC	PQTPLYT	DEG_SCF_FBW7_1	1128:1134	Mutation rewiring degron network	0.1389
p.T886M	TCGA-59-2349	OV	TCGA	KKENS	DEG_APCC_KENBOX_2	887:891	Mutation rewiring degron network	0.3056
p.T886M	DO28621	OV	ICGC	KKENS	DEG_APCC_KENBOX_2	887:891	Mutation rewiring degron network	0.3056
p.E889Q	TCGA-66-2785	LUSC	TCGA	KKENS	DEG_APCC_KENBOX_2	887:891	Mutation altering degron motif	0.6744
p.E889Q	DO26520	LUSC	ICGC	KKENS	DEG_APCC_KENBOX_2	887:891	Mutation altering degron motif	0.6744
p.T353M	TCGA-A6-6781	COAD	TCGA	PTSST	DEG_SPOP_SBC_1	352:356	Mutation altering degron motif	0.6312
p.T353M	DO8447	COAD	ICGC	PTSST	DEG_SPOP_SBC_1	352:356	Mutation altering degron motif	0.6312
p.A178V	TCGA-AA-A010	COAD	TCGA	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	157:170	Mutation rewiring degron network	0.1111
p.S1125C	TCGA-AC-A23H	BRCA	TCGA	PQTPLYT	DEG_SCF_FBW7_1	1128:1134	Mutation blocking phosphorylation signal	0.6944
p.S1125C	DO2401	BRCA	ICGC	PQTPLYT	DEG_SCF_FBW7_1	1128:1134	Mutation blocking phosphorylation signal	0.6944
p.A885V	TCGA-AP-A1DK	UCEC	TCGA	KKENS	DEG_APCC_KENBOX_2	887:891	Mutation rewiring degron network	0.2778
p.A885V	DO42033	UCEC	ICGC	KKENS	DEG_APCC_KENBOX_2	887:891	Mutation rewiring degron network	0.2778
p.L342I	TCGA-AP-A1DV	UCEC	TCGA	PTSST	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.0556
p.L342I	DO43186	UCEC	ICGC	PTSST	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.0556
p.G1724S	TCGA-B5-A3FC	UCEC	TCGA	IHRTPILE	DEG_SCF_FBW7_2	1729:1736	Mutation rewiring degron network	0.1944
p.G1724S	DO227976	COCA	ICGC	IHRTPILE	DEG_SCF_FBW7_2	1729:1736	Mutation rewiring degron network	0.1944
p.G1724S	DO41871	UCEC	ICGC	IHRTPILE	DEG_SCF_FBW7_2	1729:1736	Mutation rewiring degron network	0.1944
p.P1236S	TCGA-BR-4201	STAD	TCGA	RRECLTPIR	DEG_APCC_DBOX_1	1237:1245	Mutation rewiring degron network	0.3056
p.P1236S	TCGA-BR-4201	STAD	TCGA	PPTSS	DEG_SPOP_SBC_1	1228:1232	Mutation rewiring degron network	0.2222
p.P1236S	DO38707	STAD	ICGC	RRECLTPIR	DEG_APCC_DBOX_1	1237:1245	Mutation rewiring degron network	0.3056
p.P1236S	DO38707	STAD	ICGC	PPTSS	DEG_SPOP_SBC_1	1228:1232	Mutation rewiring degron network	0.2222
p.A1691V	TCGA-BR-4363	STAD	TCGA	AGSSS	DEG_SPOP_SBC_1	1696:1700	Mutation rewiring degron network	0.1944
p.A1691V	DO38815	STAD	ICGC	AGSSS	DEG_SPOP_SBC_1	1696:1700	Mutation rewiring degron network	0.1944
p.A347S	TCGA-CN-6020	HNSC	TCGA	PTSST	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.1944
p.A347S	DO14550	HNSC	ICGC	PTSST	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.1944
p.S163L	TCGA-CV-6951	HNSC	TCGA	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	157:170	Mutation altering degron motif	0.6556
p.S163L	TCGA-DK-A3IQ	BLCA	TCGA	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	157:170	Mutation altering degron motif	0.6556
p.S163L	DO445	BLCA	ICGC	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	157:170	Mutation altering degron motif	0.6556
p.S163L	DO15278	HNSC	ICGC	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	157:170	Mutation altering degron motif	0.6556
p.S1728N	TCGA-D1-A0ZO	UCEC	TCGA	IHRTPILE	DEG_SCF_FBW7_2	1729:1736	Mutation rewiring degron network	0.3056
p.S1728N	DO41927	UCEC	ICGC	IHRTPILE	DEG_SCF_FBW7_2	1729:1736	Mutation rewiring degron network	0.3056
p.P352T	TCGA-D3-A2JB	SKCM	TCGA	PTSST	DEG_SPOP_SBC_1	352:356	Mutation altering degron motif	0.7031
p.P352T	DO47607	SKCM	ICGC	PTSST	DEG_SPOP_SBC_1	352:356	Mutation altering degron motif	0.7031
p.P1252Q	TCGA-D3-A3CE	SKCM	TCGA	RRECLTPIR	DEG_APCC_DBOX_1	1237:1245	Mutation rewiring degron network	0.1389
p.P1252Q	DO37405	SKCM	ICGC	RRECLTPIR	DEG_APCC_DBOX_1	1237:1245	Mutation rewiring degron network	0.1389
p.P1362S	TCGA-D6-6516	HNSC	TCGA	QRATLDTVP	DEG_APCC_DBOX_1	1366:1374	Mutation rewiring degron network	0.2222
p.P1362S	DO15623	HNSC	ICGC	QRATLDTVP	DEG_APCC_DBOX_1	1366:1374	Mutation rewiring degron network	0.2222
p.K1383N	TCGA-D8-A1Y3	BRCA	TCGA	QRATLDTVP	DEG_APCC_DBOX_1	1366:1374	Mutation substituting flanking lysine	0.1944
p.K1383N	DO3107	BRCA	ICGC	QRATLDTVP	DEG_APCC_DBOX_1	1366:1374	Mutation substituting flanking lysine	0.1944
p.I1124M	TCGA-E5-A4TZ	BLCA	TCGA	PQTPLYT	DEG_SCF_FBW7_1	1128:1134	Mutation rewiring degron network	0.2222
p.I1124M	DO44055	BLCA	ICGC	PQTPLYT	DEG_SCF_FBW7_1	1128:1134	Mutation rewiring degron network	0.2222
p.P893H	TCGA-EE-A17Z	SKCM	TCGA	KKENS	DEG_APCC_KENBOX_2	887:891	Mutation rewiring degron network	0.2778
p.P893H	DO37921	SKCM	ICGC	KKENS	DEG_APCC_KENBOX_2	887:891	Mutation rewiring degron network	0.2778
p.P159T	TCGA-EM-A2CL	THCA	TCGA	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	157:170	Mutation altering degron motif	0.7031
p.P159T	DO40640	THCA	ICGC	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	157:170	Mutation altering degron motif	0.7031
p.G1697C	TCGA-EY-A1GU	UCEC	TCGA	AGSSS	DEG_SPOP_SBC_1	1696:1700	Mutation altering degron motif	0.6489
p.G1697C	DO41518	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	1696:1700	Mutation altering degron motif	0.6489
p.E175K	TCGA-FD-A3SO	BLCA	TCGA	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	157:170	Mutation rewiring degron network	0.1944
p.E175K	TCGA-S5-A6DX	BLCA	TCGA	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	157:170	Mutation rewiring degron network	0.1944
p.E175K	DO48413	BLCA	ICGC	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	157:170	Mutation rewiring degron network	0.1944
p.E175K	DO51903	BLCA	ICGC	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	157:170	Mutation rewiring degron network	0.1944
p.E175K	DO569	BLCA	ICGC	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	157:170	Mutation rewiring degron network	0.1944
p.A1696T	TCGA-FI-A2D5	UCEC	TCGA	AGSSS	DEG_SPOP_SBC_1	1696:1700	Mutation altering degron motif	0.7139
p.A1696T	DO41331	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	1696:1700	Mutation altering degron motif	0.7139
p.T1360A	TCGA-G4-6588	COAD	TCGA	QRATLDTVP	DEG_APCC_DBOX_1	1366:1374	Mutation blocking phosphorylation signal	0.6111
p.T1360A	DO10140	COAD	ICGC	QRATLDTVP	DEG_APCC_DBOX_1	1366:1374	Mutation blocking phosphorylation signal	0.6111
p.S1224C	TCGA-J1-A4AH	LUSC	TCGA	PPTSS	DEG_SPOP_SBC_1	1228:1232	Mutation rewiring degron network	0.2222
p.S1224C	DO45479	LUSC	ICGC	PPTSS	DEG_SPOP_SBC_1	1228:1232	Mutation rewiring degron network	0.2222
p.S1698F	TCGA-VS-A958	CESC	TCGA	AGSSS	DEG_SPOP_SBC_1	1696:1700	Mutation altering degron motif	0.7982
p.S1698F	DO51639	CESC	ICGC	AGSSS	DEG_SPOP_SBC_1	1696:1700	Mutation altering degron motif	0.7982
p.E1136Q	TCGA-ZJ-A8QR	CESC	TCGA	PQTPLYT	DEG_SCF_FBW7_1	1128:1134	Mutation rewiring degron network	0.2778
p.E1136Q	DO219749	CESC	ICGC	PQTPLYT	DEG_SCF_FBW7_1	1128:1134	Mutation rewiring degron network	0.2778
p.K887E	DO227802	COCA	ICGC	KKENS	DEG_APCC_KENBOX_2	887:891	Mutation altering degron motif	0.591
p.V1373I	DO229013	COCA	ICGC	QRATLDTVP	DEG_APCC_DBOX_1	1366:1374	Mutation altering degron motif	0.5965
p.V1373I	DO229003	COCA	ICGC	QRATLDTVP	DEG_APCC_DBOX_1	1366:1374	Mutation altering degron motif	0.5965
p.L147F	DO233124	GACA	ICGC	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	157:170	Mutation rewiring degron network	0.0556
p.A1368S	DO228952	LICA	ICGC	QRATLDTVP	DEG_APCC_DBOX_1	1366:1374	Mutation altering degron motif	0.6477
p.A1707S	DO229025	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	1696:1700	Mutation rewiring degron network	0.1389
p.Q896H	DO229031	LICA	ICGC	KKENS	DEG_APCC_KENBOX_2	887:891	Mutation rewiring degron network	0.1944
p.G344V	DO229009	LICA	ICGC	PTSST	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.1111
p.P161S	DO220885	MELA	ICGC	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	157:170	Mutation altering degron motif	0.5641
p.W349L	DO222557	MELA	ICGC	PTSST	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.25
p.E175Q	SIDM00630	Breast Carcinoma	GDSC	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	157:170	Mutation rewiring degron network	0.1944
p.P1142L	SIDM00321	Ovarian Carcinoma	GDSC	PQTPLYT	DEG_SCF_FBW7_1	1128:1134	Mutation rewiring degron network	0.1111
p.P1142L	ACH-000430	Ovarian Cancer	CCLE	PQTPLYT	DEG_SCF_FBW7_1	1128:1134	Mutation rewiring degron network	0.1111
p.P1142L	TYK-nu	ovary	COSMIC	PQTPLYT	DEG_SCF_FBW7_1	1128:1134	Mutation rewiring degron network	0.1111
p.S172T	SIDM01175	Other Sarcomas	GDSC	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	157:170	Mutation rewiring degron network	0.2778
p.S172T	ACH-002309	Sarcoma	CCLE	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	157:170	Mutation rewiring degron network	0.2778
p.S172T	SW684	soft tissue	COSMIC	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	157:170	Mutation rewiring degron network	0.2778
p.T1127I	SIDM00216	Colorectal Carcinoma	GDSC	PQTPLYT	DEG_SCF_FBW7_1	1128:1134	Mutation blocking phosphorylation signal	0.75
p.T1127I	SNU-175	large intestine	COSMIC	PQTPLYT	DEG_SCF_FBW7_1	1128:1134	Mutation blocking phosphorylation signal	0.75
p.S350F	SIDM00007	Other Solid Cancers	GDSC	PTSST	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.2778
p.S350F	ACH-001550	Skin Cancer	CCLE	PTSST	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.2778
p.S350F	MCC13	skin	COSMIC	PTSST	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.2778
p.K1140N	SIDM00457	Plasma Cell Myeloma	GDSC	PQTPLYT	DEG_SCF_FBW7_1	1128:1134	Mutation substituting flanking lysine	0.2778
p.K1140N	ACH-000024	Myeloma	CCLE	PQTPLYT	DEG_SCF_FBW7_1	1128:1134	Mutation substituting flanking lysine	0.2778
p.K1140N	ACH-000057	Myeloma	CCLE	PQTPLYT	DEG_SCF_FBW7_1	1128:1134	Mutation substituting flanking lysine	0.2778
p.K1140N	OPM-2	haematopoietic and lymphoid tissue	COSMIC	PQTPLYT	DEG_SCF_FBW7_1	1128:1134	Mutation substituting flanking lysine	0.2778
p.T1732M	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	IHRTPILE	DEG_SCF_FBW7_2	1729:1736	Mutation altering degron motif	0.7423
p.T1732M	SIDM00844	Burkitt's Lymphoma	GDSC	IHRTPILE	DEG_SCF_FBW7_2	1729:1736	Mutation altering degron motif	0.7423
p.T1732M	SIDM00808	Burkitt's Lymphoma	GDSC	IHRTPILE	DEG_SCF_FBW7_2	1729:1736	Mutation altering degron motif	0.7423
p.T1732M	SIDM01254	Burkitt's Lymphoma	GDSC	IHRTPILE	DEG_SCF_FBW7_2	1729:1736	Mutation altering degron motif	0.7423
p.V881L	SIDM01118	Small Cell Lung Carcinoma	GDSC	KKENS	DEG_APCC_KENBOX_2	887:891	Mutation rewiring degron network	0.1667
p.V881L	ACH-002175	Lung Cancer	CCLE	KKENS	DEG_APCC_KENBOX_2	887:891	Mutation rewiring degron network	0.1667
p.V881L	NCI-H740	lung	COSMIC	KKENS	DEG_APCC_KENBOX_2	887:891	Mutation rewiring degron network	0.1667
p.L1735S	SIDM00892	Breast Carcinoma	GDSC	IHRTPILE	DEG_SCF_FBW7_2	1729:1736	Mutation altering degron motif	0.6556
p.L1735S	ACH-000818	Breast Cancer	CCLE	IHRTPILE	DEG_SCF_FBW7_2	1729:1736	Mutation altering degron motif	0.6556
p.L1735S	BT-483	breast	COSMIC	IHRTPILE	DEG_SCF_FBW7_2	1729:1736	Mutation altering degron motif	0.6556
p.G148W	SIDM00245	Small Cell Lung Carcinoma	GDSC	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	157:170	Mutation rewiring degron network	0.0833
p.G148W	ACH-001131	Skin Cancer	CCLE	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	157:170	Mutation rewiring degron network	0.0833
p.G148W	ACH-001958	lung	CCLE	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	157:170	Mutation rewiring degron network	0.0833
p.G148W	MS-1	lung	COSMIC	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	157:170	Mutation rewiring degron network	0.0833
p.A176T	SIDM00217	Colorectal Carcinoma	GDSC	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	157:170	Mutation rewiring degron network	0.1667
p.A176T	ACH-000999	Colon/Colorectal Cancer	CCLE	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	157:170	Mutation rewiring degron network	0.1667
p.A176T	SNU-1040	large intestine	COSMIC	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	157:170	Mutation rewiring degron network	0.1667
p.R1384Q	SIDM00921	Non-Small Cell Lung Carcinoma	GDSC	QRATLDTVP	DEG_APCC_DBOX_1	1366:1374	Mutation rewiring degron network	0.0556
p.P893R	SIDM00257	Neuroblastoma	GDSC	KKENS	DEG_APCC_KENBOX_2	887:891	Mutation rewiring degron network	0.2778
p.P893R	NB13	autonomic ganglia	COSMIC	KKENS	DEG_APCC_KENBOX_2	887:891	Mutation rewiring degron network	0.2778
p.P1686S	SIDM00780	Colorectal Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	1696:1700	Mutation rewiring degron network	0.0556
p.P1686S	ACH-000967	Colon/Colorectal Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	1696:1700	Mutation rewiring degron network	0.0556
p.R1384W	ACH-001862	Bile Duct Cancer	CCLE	QRATLDTVP	DEG_APCC_DBOX_1	1366:1374	Mutation rewiring degron network	0.0556
p.E1221K	ACH-002005	Skin Cancer	CCLE	PPTSS	DEG_SPOP_SBC_1	1228:1232	Mutation rewiring degron network	0.1389
p.P893S	ACH-002026	Endometrial/Uterine Cancer	CCLE	KKENS	DEG_APCC_KENBOX_2	887:891	Mutation rewiring degron network	0.2778
p.P892R	NB13	autonomic ganglia	COSMIC	KKENS	DEG_APCC_KENBOX_2	887:891	Mutation rewiring degron network	0.3056
p.A1696V	CAL-85-1	breast	COSMIC	AGSSS	DEG_SPOP_SBC_1	1696:1700	Mutation altering degron motif	0.5825
p.L1734S	BT-483	breast	COSMIC	IHRTPILE	DEG_SCF_FBW7_2	1729:1736	Mutation altering degron motif	0.7667
p.T1126I	SNU-175	large intestine	COSMIC	PQTPLYT	DEG_SCF_FBW7_1	1128:1134	Mutation rewiring degron network	0.2778
p.S349F	MCC13	skin	COSMIC	PTSST	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.25
p.V880L	NCI-H740	lung	COSMIC	KKENS	DEG_APCC_KENBOX_2	887:891	Mutation substituting flanking lysine	0.25
p.P1120A	NCI-H2066	lung	COSMIC	PQTPLYT	DEG_SCF_FBW7_1	1128:1134	Mutation blocking phosphorylation signal	0.5556
p.P1141L	TYK-nu	ovary	COSMIC	PQTPLYT	DEG_SCF_FBW7_1	1128:1134	Mutation blocking phosphorylation signal	0.5833
p.K1139N	OPM-2	haematopoietic and lymphoid tissue	COSMIC	PQTPLYT	DEG_SCF_FBW7_1	1128:1134	Mutation rewiring degron network	0.1944
p.A1695V	CAL-85-1	breast	COSMIC	AGSSS	DEG_SPOP_SBC_1	1696:1700	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TICRR

UniProt ID: Q7Z2Z1

Entrez ID: 90381

Protein name: Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TICRR in