DegronMD

Uniprot ID: Q7Z2Z1

Source protein: Treslin

Source gene: TICRR

Class: DEG_ODPH_VHL_1

Location: 157:170

E3 ligase: VHL

DEGRON score: 0.8285

ASA_SCORE: 52.5714

COIL: 0.3946

CONS_SCORE: 0.542

DSS_SCORE: 0.1205

HELIX: 0.4741

FCONS_SCORE: 1.3872

RIG_SCORE: 0.7953

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A178V	TCGA-AA-A010	COAD	TCGA	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	0.1111
p.S163L	TCGA-CV-6951	HNSC	TCGA	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	0.6556
p.S163L	TCGA-DK-A3IQ	BLCA	TCGA	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	0.6556
p.S163L	DO445	BLCA	ICGC	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	0.6556
p.S163L	DO15278	HNSC	ICGC	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	0.6556
p.P159T	TCGA-EM-A2CL	THCA	TCGA	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	0.7031
p.P159T	DO40640	THCA	ICGC	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	0.7031
p.E175K	TCGA-FD-A3SO	BLCA	TCGA	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	0.1944
p.E175K	TCGA-S5-A6DX	BLCA	TCGA	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	0.1944
p.E175K	DO48413	BLCA	ICGC	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	0.1944
p.E175K	DO51903	BLCA	ICGC	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	0.1944
p.E175K	DO569	BLCA	ICGC	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	0.1944
p.L147F	DO233124	GACA	ICGC	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	0.0556
p.P161S	DO220885	MELA	ICGC	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	0.5641
p.E175Q	SIDM00630	Breast Carcinoma	GDSC	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	0.1944
p.S172T	SIDM01175	Other Sarcomas	GDSC	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	0.2778
p.S172T	ACH-002309	Sarcoma	CCLE	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	0.2778
p.S172T	SW684	soft_tissue	COSMIC	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	0.2778
p.G148W	SIDM00245	Small Cell Lung Carcinoma	GDSC	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	0.0833
p.G148W	ACH-001131	Skin Cancer	CCLE	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	0.0833
p.G148W	ACH-001958	lung	CCLE	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	0.0833
p.G148W	MS-1	lung	COSMIC	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	0.0833
p.A176T	SIDM00217	Colorectal Carcinoma	GDSC	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	0.1667
p.A176T	ACH-000999	Colon/Colorectal Cancer	CCLE	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	0.1667
p.A176T	SNU-1040	large_intestine	COSMIC	LAPCPHSQRELLQF	DEG_ODPH_VHL_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z2Z1	Treslin	DEG_ODPH_VHL_1	157:170	LAPCPHSQRELLQF	VHL	0.8285	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPCPHSQRELLQF

Degron related mutations and impact score

Drug responses associated with TICRR mutations

All proteins holding degron of LAPCPHSQRELLQF