DegronMD

Uniprot ID: Q7Z2Z1

Source protein: Treslin

Source gene: TICRR

Class: DEG_SCF_FBW7_2

Location: 1729:1736

E3 ligase: FBXW7

DEGRON score: 0.6473

ASA_SCORE: 92.0625

COIL: 0.808

CONS_SCORE: 0.2863

DSS_SCORE: 0.3654

HELIX: 0.1378

FCONS_SCORE: 0.7548

RIG_SCORE: 0.7771

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1734S	BT-483	breast	COSMIC	IHRTPILE	DEG_SCF_FBW7_2	0.7667
p.T1732M	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	IHRTPILE	DEG_SCF_FBW7_2	0.7423
p.T1732M	SIDM00844	Burkitt's Lymphoma	GDSC	IHRTPILE	DEG_SCF_FBW7_2	0.7423
p.T1732M	SIDM00808	Burkitt's Lymphoma	GDSC	IHRTPILE	DEG_SCF_FBW7_2	0.7423
p.T1732M	SIDM01254	Burkitt's Lymphoma	GDSC	IHRTPILE	DEG_SCF_FBW7_2	0.7423
p.L1735S	SIDM00892	Breast Carcinoma	GDSC	IHRTPILE	DEG_SCF_FBW7_2	0.6556
p.L1735S	ACH-000818	Breast Cancer	CCLE	IHRTPILE	DEG_SCF_FBW7_2	0.6556
p.L1735S	BT-483	breast	COSMIC	IHRTPILE	DEG_SCF_FBW7_2	0.6556
p.S1728N	TCGA-D1-A0ZO	UCEC	TCGA	IHRTPILE	DEG_SCF_FBW7_2	0.3056
p.S1728N	DO41927	UCEC	ICGC	IHRTPILE	DEG_SCF_FBW7_2	0.3056
p.G1724S	TCGA-B5-A3FC	UCEC	TCGA	IHRTPILE	DEG_SCF_FBW7_2	0.1944
p.G1724S	DO227976	COCA	ICGC	IHRTPILE	DEG_SCF_FBW7_2	0.1944
p.G1724S	DO41871	UCEC	ICGC	IHRTPILE	DEG_SCF_FBW7_2	0.1944

Showing 1 to 13 of 13 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z2Z1	Treslin	DEG_SCF_FBW7_2	1729:1736	IHRTPILE	FBXW7	0.6473	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons