DegronMD

Uniprot ID: Q7Z2Z1

Source protein: Treslin

Source gene: TICRR

Class: DEG_APCC_KENBOX_2

Location: 887:891

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9836

ASA_SCORE: 136.74

COIL: 0.9486

CONS_SCORE: 0.3958

DSS_SCORE: 0.7831

HELIX: 0.0352

FCONS_SCORE: 0.9659

RIG_SCORE: 0.57

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R884T	TCGA-4Z-AA7Q	BLCA	TCGA	KKENS	DEG_APCC_KENBOX_2	0.25
p.R884T	DO218980	BLCA	ICGC	KKENS	DEG_APCC_KENBOX_2	0.25
p.T886M	TCGA-59-2349	OV	TCGA	KKENS	DEG_APCC_KENBOX_2	0.3056
p.T886M	DO28621	OV	ICGC	KKENS	DEG_APCC_KENBOX_2	0.3056
p.E889Q	TCGA-66-2785	LUSC	TCGA	KKENS	DEG_APCC_KENBOX_2	0.6744
p.E889Q	DO26520	LUSC	ICGC	KKENS	DEG_APCC_KENBOX_2	0.6744
p.A885V	TCGA-AP-A1DK	UCEC	TCGA	KKENS	DEG_APCC_KENBOX_2	0.2778
p.A885V	DO42033	UCEC	ICGC	KKENS	DEG_APCC_KENBOX_2	0.2778
p.P893H	TCGA-EE-A17Z	SKCM	TCGA	KKENS	DEG_APCC_KENBOX_2	0.2778
p.P893H	DO37921	SKCM	ICGC	KKENS	DEG_APCC_KENBOX_2	0.2778
p.K887E	DO227802	COCA	ICGC	KKENS	DEG_APCC_KENBOX_2	0.591
p.Q896H	DO229031	LICA	ICGC	KKENS	DEG_APCC_KENBOX_2	0.1944
p.V881L	SIDM01118	Small Cell Lung Carcinoma	GDSC	KKENS	DEG_APCC_KENBOX_2	0.1667
p.V881L	ACH-002175	Lung Cancer	CCLE	KKENS	DEG_APCC_KENBOX_2	0.1667
p.V881L	NCI-H740	lung	COSMIC	KKENS	DEG_APCC_KENBOX_2	0.1667
p.P893R	SIDM00257	Neuroblastoma	GDSC	KKENS	DEG_APCC_KENBOX_2	0.2778
p.P893R	NB13	autonomic_ganglia	COSMIC	KKENS	DEG_APCC_KENBOX_2	0.2778
p.P893S	ACH-002026	Endometrial/Uterine Cancer	CCLE	KKENS	DEG_APCC_KENBOX_2	0.2778
p.P892R	NB13	autonomic_ganglia	COSMIC	KKENS	DEG_APCC_KENBOX_2	0.3056
p.V880L	NCI-H740	lung	COSMIC	KKENS	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15151	Protein Mdm4	DEG_APCC_KENBOX_2	379:383	KKENS	APC,CDC20,FZR1	0.6013	More...
O60242	Adhesion G protein-coupled receptor B3	DEG_APCC_KENBOX_2	1271:1275	KKENS	APC,CDC20,FZR1	0.6429	More...
P29965	CD40 ligand	DEG_APCC_KENBOX_2	106:110	KKENS	APC,CDC20,FZR1	0.7872	More...
P56715	Oxygen-regulated protein 1	DEG_APCC_KENBOX_2	534:538	KKENS	APC,CDC20,FZR1	0.6968	More...
P98082	Disabled homolog 2	DEG_APCC_KENBOX_2	320:324	KKENS	APC,CDC20,FZR1	0.6959	More...
Q7Z2Z1	Treslin	DEG_APCC_KENBOX_2	887:891	KKENS	APC,CDC20,FZR1	0.9836	More...
Q9GZS3	WD repeat-containing protein 61	DEG_APCC_KENBOX_2	28:32	KKENS	APC,CDC20,FZR1	0.5187	More...
Q9NQW8	Cyclic nucleotide-gated cation channel beta-3	DEG_APCC_KENBOX_2	702:706	KKENS	APC,CDC20,FZR1	0.5372	More...
O00515	Ladinin-1	DEG_APCC_KENBOX_2	381:385	KKENS	APC,CDC20,FZR1	0.9602	More...
Q9BY89	Uncharacterized protein KIAA1671	DEG_APCC_KENBOX_2	669:673	KKENS	APC,CDC20,FZR1	0.7067	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons