CD40LG
UniProt ID: P29965
Entrez ID: 959
Protein name: CD40 ligand (CD40-L) (T-cell antigen Gp39) (TNF-related activation protein) (TRAP) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)]
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Cytokine that acts as a ligand to CD40/TNFRSF5 (PubMed:1280226, PubMed:31331973). Costimulates T-cell proliferation and cytokine production (PubMed:8617933). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the ...
FUNCTION: Cytokine that acts as a ligand to CD40/TNFRSF5 (PubMed:1280226, PubMed:31331973). Costimulates T-cell proliferation and cytokine production (PubMed:8617933). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (PubMed:8617933). Induces the activation of NF-kappa-B (PubMed:15067037, PubMed:31331973). Induces the activation of kinases MAPK8 and PAK2 in T-cells (PubMed:15067037). Induces tyrosine phosphorylation of isoform 3 of CD28 (PubMed:15067037). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity). {ECO:0000250|UniProtKB:P27548, ECO:0000269|PubMed:1280226, ECO:0000269|PubMed:15067037, ECO:0000269|PubMed:31331973, ECO:0000269|PubMed:8617933}.; FUNCTION: [CD40 ligand, soluble form]: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling. {ECO:0000269|PubMed:31331973}.
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GO - Biological processes (BP):
B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; CD40 signaling pathway [GO:0023035]; inflammatory response [GO:0006954]; integrin-mediated signaling pathway [GO:0007229]; isotype switching [GO:0045190]; leukocyte cell-cell adhesion [GO:0007159]; negative regulation of apoptot...
B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; CD40 signaling pathway [GO:0023035]; inflammatory response [GO:0006954]; integrin-mediated signaling pathway [GO:0007229]; isotype switching [GO:0045190]; leukocyte cell-cell adhesion [GO:0007159]; negative regulation of apoptotic process [GO:0043066]; platelet activation [GO:0030168]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of T cell proliferation [GO:0042102]; regulation of immunoglobulin production [GO:0002637]; T cell costimulation [GO:0031295]
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GO - Molecular function (MF):
CD40 receptor binding [GO:0005174]; cytokine activity [GO:0005125]; integrin binding [GO:0005178]; protein serine/threonine kinase activator activity [GO:0043539]; tumor necrosis factor receptor binding [GO:0005164]...
CD40 receptor binding [GO:0005174]; cytokine activity [GO:0005125]; integrin binding [GO:0005178]; protein serine/threonine kinase activator activity [GO:0043539]; tumor necrosis factor receptor binding [GO:0005164]
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GO - Cellular component (CC):
cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]...
cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]
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CD40LG
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*NOTE: the Kaplan plots were collected from OncoLnc