DegronMD

Uniprot ID: O15151

Source protein: Protein Mdm4

Source gene: MDM4

Class: DEG_APCC_KENBOX_2

Location: 379:383

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6013

ASA_SCORE: 100.04

COIL: 0.6438

CONS_SCORE: 0.2907

DSS_SCORE: 0.3851

HELIX: 0.2494

FCONS_SCORE: 0.8896

RIG_SCORE: 0.7751

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V371I	TCGA-AA-A010	COAD	TCGA	KKENS	DEG_APCC_KENBOX_2	0.1111
p.V371I	TCGA-CG-5728	STAD	TCGA	KKENS	DEG_APCC_KENBOX_2	0.1111
p.E393G	TCGA-AP-A059	UCEC	TCGA	KKENS	DEG_APCC_KENBOX_2	0.0556
p.E393G	DO41361	UCEC	ICGC	KKENS	DEG_APCC_KENBOX_2	0.0556
p.E381D	TCGA-B5-A1MR	UCEC	TCGA	KKENS	DEG_APCC_KENBOX_2	0.6758
p.P369S	TCGA-D6-6516	HNSC	TCGA	KKENS	DEG_APCC_KENBOX_2	0.0556
p.P369S	DO15623	HNSC	ICGC	KKENS	DEG_APCC_KENBOX_2	0.0556
p.L383I	DO13863	GBM	ICGC	KKENS	DEG_APCC_KENBOX_2	0.7174
p.L383F	DO220859	MELA	ICGC	KKENS	DEG_APCC_KENBOX_2	0.6981
p.D375G	SIDM01058	B-Cell Non-Hodgkin's Lymphoma	GDSC	KKENS	DEG_APCC_KENBOX_2	0.2222
p.D375G	ACH-000073	Lymphoma	CCLE	KKENS	DEG_APCC_KENBOX_2	0.2222
p.D375G	GRANTA-519	haematopoietic_and_lymphoid_tissue	COSMIC	KKENS	DEG_APCC_KENBOX_2	0.2222
p.D375Y	SIDM01058	B-Cell Non-Hodgkin's Lymphoma	GDSC	KKENS	DEG_APCC_KENBOX_2	0.2222
p.D375Y	GRANTA-519	haematopoietic_and_lymphoid_tissue	COSMIC	KKENS	DEG_APCC_KENBOX_2	0.2222
p.P388A	SIDM00857	Melanoma	GDSC	KKENS	DEG_APCC_KENBOX_2	0.1944
p.P388A	SIDM00885	Breast Carcinoma	GDSC	KKENS	DEG_APCC_KENBOX_2	0.1944
p.P388A	SIDM00057	Neuroblastoma	GDSC	KKENS	DEG_APCC_KENBOX_2	0.1944
p.P388A	SIDM00210	Ovarian Carcinoma	GDSC	KKENS	DEG_APCC_KENBOX_2	0.1944
p.P388A	SIDM00869	Non-Cancerous	GDSC	KKENS	DEG_APCC_KENBOX_2	0.1944
p.P388A	SIDM00145	T-Lymphoblastic Leukemia	GDSC	KKENS	DEG_APCC_KENBOX_2	0.1944
p.P388A	SIDM00153	T-Lymphoblastic Leukemia	GDSC	KKENS	DEG_APCC_KENBOX_2	0.1944
p.P388A	SIDM01761	Rhabdomyosarcoma	GDSC	KKENS	DEG_APCC_KENBOX_2	0.1944
p.K384E	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	KKENS	DEG_APCC_KENBOX_2	0.75
p.K384E	ACH-000444	Lung Cancer	CCLE	KKENS	DEG_APCC_KENBOX_2	0.75
p.K384E	LU-99A	lung	COSMIC	KKENS	DEG_APCC_KENBOX_2	0.75
p.C389R	SIDM00333	Endometrial Carcinoma	GDSC	KKENS	DEG_APCC_KENBOX_2	0.1667
p.C389R	MFE-319	endometrium	COSMIC	KKENS	DEG_APCC_KENBOX_2	0.1667
p.A376E	SIDM01608	Endometrial Carcinoma	GDSC	KKENS	DEG_APCC_KENBOX_2	0.25
p.A376E	ACH-000990	Endometrial/Uterine Cancer	CCLE	KKENS	DEG_APCC_KENBOX_2	0.25
p.D375C	ACH-000073	Lymphoma	CCLE	KKENS	DEG_APCC_KENBOX_2	0.2222
p.C389G	ACH-000261	Lung Cancer	CCLE	KKENS	DEG_APCC_KENBOX_2	0.1667
p.C389G	ACH-002122	Lung Cancer	CCLE	KKENS	DEG_APCC_KENBOX_2	0.1667
p.T372I	NCI-H1155	lung	COSMIC	KKENS	DEG_APCC_KENBOX_2	0.1389
p.M377I	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	KKENS	DEG_APCC_KENBOX_2	0.2778

Drug responses associated with MDM4 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00889	CESC\|cervix	p.N281fs*10 (No)	GDSC	NSC-207895	2.1589
SIDM00172	HNSC\|head_and_neck	p.S367L (No)	GDSC	NSC-207895	36.1239
SIDM01024	ESCA\|oesophagus	p.R87C (No)	GDSC	NSC-207895	350.0952
SIDM00210	UNCLASSIFIED\|ovary	p.P388A (Yes)	GDSC	NSC-207895	35.2024
SIDM00145	ALL\|lymphoblastic_leukemia	p.P388A (Yes)	GDSC	NSC-207895	30.2439
SIDM00724	LUAD\|lung_NSCLC_adenocarcinoma	p.S14R (No)	GDSC	NSC-207895	362.7022
SIDM00461	LAML\|acute_myeloid_leukaemia	p.S127T (No)	GDSC	NSC-207895	19.2099
SIDM00461	LAML\|acute_myeloid_leukaemia	p.I130F (No)	GDSC	NSC-207895	19.2099
SIDM00461	LAML\|acute_myeloid_leukaemia	p.Q135R (No)	GDSC	NSC-207895	19.2099
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.T422I (No)	GDSC	NSC-207895	96.6878
SIDM00762	LUAD\|lung_NSCLC_adenocarcinoma	p.S14R (No)	GDSC	NSC-207895	16.9507
SIDM01058	DLBC\|B_cell_lymphoma	p.D375Y (Yes)	GDSC	NSC-207895	203.8699
SIDM01058	DLBC\|B_cell_lymphoma	p.D375G (Yes)	GDSC	NSC-207895	203.8699
SIDM00618	LIHC\|liver	p.R87C (No)	GDSC	NSC-207895	10.5049
SIDM00521	SCLC\|lung_small_cell_carcinoma	p.S14R (No)	GDSC	NSC-207895	20.8011
SIDM01028	ESCA\|oesophagus	p.R322C (No)	GDSC	NSC-207895	16.7858
SIDM00333	UCEC\|endometrium	p.C389R (Yes)	GDSC	NSC-207895	225.9946
SIDM00794	UNCLASSIFIED\|skin_other	p.S14R (No)	GDSC	NSC-207895	11.1156
SIDM00783	COREAD\|large_intestine	p.N281fs*10 (No)	GDSC	NSC-207895	100.8048
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.C24* (No)	GDSC	NSC-207895	280.8813
SIDM01247	UNCLASSIFIED\|Burkitt_lymphoma	p.S14R (No)	GDSC	NSC-207895	28.8662
SIDM00205	UNCLASSIFIED\|ewings_sarcoma	p.E128G (No)	GDSC	NSC-207895	80.3964
SIDM00150	COREAD\|large_intestine	p.E297D (No)	GDSC	NSC-207895	121.6425
SIDM01100	NB\|neuroblastoma	p.I175T (No)	GDSC	NSC-207895	218.2214
SIDM00954	BRCA\|breast	p.A8T (No)	GDSC	NSC-207895	34.7225
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.S127T (No)	GDSC	NSC-207895	7.8934
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.I130F (No)	GDSC	NSC-207895	7.8934
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.Q135R (No)	GDSC	NSC-207895	7.8934
SIDM00789	COREAD\|large_intestine	p.C76Y (No)	GDSC	NSC-207895	39.8834
SIDM00534	COREAD\|large_intestine	p.D233Y (No)	GDSC	NSC-207895	267.9692
SIDM00273	LGG\|glioma	p.R363Q (No)	GDSC	NSC-207895	14.2244
SIDM00487	COREAD\|large_intestine	p.V267A (No)	GDSC	NSC-207895	29.317
SIDM00850	STAD\|stomach	p.I175T (No)	GDSC	NSC-207895	11.7294
SIDM00245	SCLC\|lung_small_cell_carcinoma	p.R87C (No)	GDSC	NSC-207895	28.5296
SIDM00670	PAAD\|pancreas	p.S14R (No)	GDSC	NSC-207895	73.2752
SIDM00285	NB\|neuroblastoma	p.G279V (No)	GDSC	NSC-207895	14.1114
SIDM01130	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.V226M (No)	GDSC	NSC-207895	81.8005
SIDM00983	BLCA\|bladder	p.S161* (No)	GDSC	NSC-207895	5.7053
SIDM00277	UNCLASSIFIED\|haematopoietic_neoplasm_other	p.S367L (No)	GDSC	NSC-207895	6.9462
SIDM00878	BRCA\|breast	p.A8T (No)	GDSC	NSC-207895	131.687
SIDM00857	SKCM\|melanoma	p.P388A (Yes)	GDSC	NSC-207895	18.073
SIDM01219	UNCLASSIFIED\|lung_NSCLC_large_cell	p.K384E (Yes)	GDSC	NSC-207895	143.7545

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15151	Protein Mdm4	DEG_APCC_KENBOX_2	379:383	KKENS	APC,CDC20,FZR1	0.6013	More...
O60242	Adhesion G protein-coupled receptor B3	DEG_APCC_KENBOX_2	1271:1275	KKENS	APC,CDC20,FZR1	0.6429	More...
P29965	CD40 ligand	DEG_APCC_KENBOX_2	106:110	KKENS	APC,CDC20,FZR1	0.7872	More...
P56715	Oxygen-regulated protein 1	DEG_APCC_KENBOX_2	534:538	KKENS	APC,CDC20,FZR1	0.6968	More...
P98082	Disabled homolog 2	DEG_APCC_KENBOX_2	320:324	KKENS	APC,CDC20,FZR1	0.6959	More...
Q7Z2Z1	Treslin	DEG_APCC_KENBOX_2	887:891	KKENS	APC,CDC20,FZR1	0.9836	More...
Q9GZS3	WD repeat-containing protein 61	DEG_APCC_KENBOX_2	28:32	KKENS	APC,CDC20,FZR1	0.5187	More...
Q9NQW8	Cyclic nucleotide-gated cation channel beta-3	DEG_APCC_KENBOX_2	702:706	KKENS	APC,CDC20,FZR1	0.5372	More...
O00515	Ladinin-1	DEG_APCC_KENBOX_2	381:385	KKENS	APC,CDC20,FZR1	0.9602	More...
Q9BY89	Uncharacterized protein KIAA1671	DEG_APCC_KENBOX_2	669:673	KKENS	APC,CDC20,FZR1	0.7067	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KKENS

Degron related mutations and impact score

Drug responses associated with MDM4 mutations

All proteins holding degron of KKENS