DegronMD

Uniprot ID: Q9GZS3

Source protein: WD repeat-containing protein 61

Source gene: WDR61

Class: DEG_APCC_KENBOX_2

Location: 28:32

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5187

ASA_SCORE: 94.44

COIL: 0.9094

CONS_SCORE: 0.4253

DSS_SCORE: 0.3245

HELIX: 0.0444

FCONS_SCORE: 0.6248

RIG_SCORE: 0.7531

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W24C	TCGA-95-7043	LUAD	TCGA	KKENS	DEG_APCC_KENBOX_2	0.2222
p.W24C	DO24739	LUAD	ICGC	KKENS	DEG_APCC_KENBOX_2	0.2222
p.T26I	TCGA-D1-A2G0	UCEC	TCGA	KKENS	DEG_APCC_KENBOX_2	0.2778
p.T26I	DO43049	UCEC	ICGC	KKENS	DEG_APCC_KENBOX_2	0.2778
p.F40S	DO222410	BTCA	ICGC	KKENS	DEG_APCC_KENBOX_2	0.1111
p.A29T	DO8240	COAD	ICGC	KKENS	DEG_APCC_KENBOX_2	0.7139
p.T26K	DO229019	LICA	ICGC	KKENS	DEG_APCC_KENBOX_2	0.2778
p.H33N	DO229022	LICA	ICGC	KKENS	DEG_APCC_KENBOX_2	0.3056
p.T30A	DO48759	LIRI	ICGC	KKENS	DEG_APCC_KENBOX_2	0.7139
p.G31E	DO26999	LUSC	ICGC	KKENS	DEG_APCC_KENBOX_2	0.7199
p.N27S	DO229065	PRAD	ICGC	KKENS	DEG_APCC_KENBOX_2	0.3056
p.A20T	DO229218	THCA	ICGC	KKENS	DEG_APCC_KENBOX_2	0.1111
p.N38D	DO42033	UCEC	ICGC	KKENS	DEG_APCC_KENBOX_2	0.1667
p.E33Q	SIDM00866	Breast Carcinoma	GDSC	KKENS	DEG_APCC_KENBOX_2	0.3056
p.E33Q	SIDM00868	Non-Cancerous	GDSC	KKENS	DEG_APCC_KENBOX_2	0.3056
p.E33Q	ACH-000374	Breast Cancer	CCLE	KKENS	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15151	Protein Mdm4	DEG_APCC_KENBOX_2	379:383	KKENS	APC,CDC20,FZR1	0.6013	More...
O60242	Adhesion G protein-coupled receptor B3	DEG_APCC_KENBOX_2	1271:1275	KKENS	APC,CDC20,FZR1	0.6429	More...
P29965	CD40 ligand	DEG_APCC_KENBOX_2	106:110	KKENS	APC,CDC20,FZR1	0.7872	More...
P56715	Oxygen-regulated protein 1	DEG_APCC_KENBOX_2	534:538	KKENS	APC,CDC20,FZR1	0.6968	More...
P98082	Disabled homolog 2	DEG_APCC_KENBOX_2	320:324	KKENS	APC,CDC20,FZR1	0.6959	More...
Q7Z2Z1	Treslin	DEG_APCC_KENBOX_2	887:891	KKENS	APC,CDC20,FZR1	0.9836	More...
Q9GZS3	WD repeat-containing protein 61	DEG_APCC_KENBOX_2	28:32	KKENS	APC,CDC20,FZR1	0.5187	More...
Q9NQW8	Cyclic nucleotide-gated cation channel beta-3	DEG_APCC_KENBOX_2	702:706	KKENS	APC,CDC20,FZR1	0.5372	More...
O00515	Ladinin-1	DEG_APCC_KENBOX_2	381:385	KKENS	APC,CDC20,FZR1	0.9602	More...
Q9BY89	Uncharacterized protein KIAA1671	DEG_APCC_KENBOX_2	669:673	KKENS	APC,CDC20,FZR1	0.7067	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons