DegronMD - O60242(ADGRB3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F1359V	SIDM01954	Colorectal Carcinoma	GDSC	LAPQEHMQNLPF	DEG_ODPH_VHL_1	1367:1378	Mutation rewiring degron network	0.1111
p.R1452W	SIDM01300	Colorectal Carcinoma	GDSC	PNTSS	DEG_SPOP_SBC_1	1455:1459	Mutation rewiring degron network	0.25
p.R1452W	SIDM00003	Melanoma	GDSC	PNTSS	DEG_SPOP_SBC_1	1455:1459	Mutation rewiring degron network	0.25
p.R1452W	M14	skin	COSMIC	PNTSS	DEG_SPOP_SBC_1	1455:1459	Mutation rewiring degron network	0.25
p.A1368T	SIDM00958	Chronic Myelogenous Leukemia	GDSC	LAPQEHMQNLPF	DEG_ODPH_VHL_1	1367:1378	Mutation altering degron motif	0.7139
p.A1368T	CML-T1	haematopoietic and lymphoid tissue	COSMIC	LAPQEHMQNLPF	DEG_ODPH_VHL_1	1367:1378	Mutation altering degron motif	0.7139
p.E1461K	SIDM00336	Melanoma	GDSC	PNTSS	DEG_SPOP_SBC_1	1455:1459	Mutation rewiring degron network	0.2778
p.E1461K	MEL-JUSO	skin	COSMIC	PNTSS	DEG_SPOP_SBC_1	1455:1459	Mutation rewiring degron network	0.2778
p.N1362T	SIDM01197	Colorectal Carcinoma	GDSC	LAPQEHMQNLPF	DEG_ODPH_VHL_1	1367:1378	Mutation rewiring degron network	0.1944
p.N1362T	SNU-C1	large intestine	COSMIC	LAPQEHMQNLPF	DEG_ODPH_VHL_1	1367:1378	Mutation rewiring degron network	0.1944
p.P1469S	SIDM01175	Other Sarcomas	GDSC	PNTSS	DEG_SPOP_SBC_1	1455:1459	Mutation rewiring degron network	0.0556
p.P1469S	SW684	soft tissue	COSMIC	PNTSS	DEG_SPOP_SBC_1	1455:1459	Mutation rewiring degron network	0.0556
p.P1469L	SIDM01175	Other Sarcomas	GDSC	PNTSS	DEG_SPOP_SBC_1	1455:1459	Mutation rewiring degron network	0.0556
p.P1469L	SIDM00126	Melanoma	GDSC	PNTSS	DEG_SPOP_SBC_1	1455:1459	Mutation rewiring degron network	0.0556
p.P1469L	SW684	soft tissue	COSMIC	PNTSS	DEG_SPOP_SBC_1	1455:1459	Mutation rewiring degron network	0.0556
p.P1469L	K2	skin	COSMIC	PNTSS	DEG_SPOP_SBC_1	1455:1459	Mutation rewiring degron network	0.0556
p.T1280S	SIDM00506	Small Cell Lung Carcinoma	GDSC	KKENS	DEG_APCC_KENBOX_2	1271:1275	Mutation rewiring degron network	0.1944
p.T1280S	COR-L88	lung	COSMIC	KKENS	DEG_APCC_KENBOX_2	1271:1275	Mutation rewiring degron network	0.1944
p.P1178S	SIDM00007	Other Solid Cancers	GDSC	ADSSS	DEG_SPOP_SBC_1	1171:1175	Mutation rewiring degron network	0.25
p.P1178S	MCC13	skin	COSMIC	ADSSS	DEG_SPOP_SBC_1	1171:1175	Mutation rewiring degron network	0.25
p.E1273K	SIDM00337	Melanoma	GDSC	KKENS	DEG_APCC_KENBOX_2	1271:1275	Mutation altering degron motif	0.7022
p.E1273K	MEL-HO	skin	COSMIC	KKENS	DEG_APCC_KENBOX_2	1271:1275	Mutation altering degron motif	0.7022
p.L1265H	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	KKENS	DEG_APCC_KENBOX_2	1271:1275	Mutation rewiring degron network	0.1667
p.L1265H	NCI-H650	lung	COSMIC	KKENS	DEG_APCC_KENBOX_2	1271:1275	Mutation rewiring degron network	0.1667
p.L1277F	SIDM00814	Other Solid Cancers	GDSC	KKENS	DEG_APCC_KENBOX_2	1271:1275	Mutation rewiring degron network	0.2778
p.L1277F	SW13	adrenal gland	COSMIC	KKENS	DEG_APCC_KENBOX_2	1271:1275	Mutation rewiring degron network	0.2778
p.I1184T	SIDM00989	Bladder Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	1171:1175	Mutation rewiring degron network	0.0833
p.I1184T	BFTC-905	urinary tract	COSMIC	ADSSS	DEG_SPOP_SBC_1	1171:1175	Mutation rewiring degron network	0.0833
p.S1173F	SIDM00248	Gastric Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	1171:1175	Mutation altering degron motif	0.7982
p.K1228N	NCI-H630	large intestine	COSMIC	NPEGLSYSTLP	CBL_PTK	1231:1241	Mutation substituting flanking lysine	0.3611
p.N1462T	HT	haematopoietic and lymphoid tissue	COSMIC	PNTSS	DEG_SPOP_SBC_1	1455:1459	Mutation rewiring degron network	0.25

Kaplan plot for ADGRB3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ADGRB3

UniProt ID: O60242

Entrez ID: 577

Protein name: Adhesion G protein-coupled receptor B3 (Brain-specific angiogenesis inhibitor 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ADGRB3 in