DegronMD

Uniprot ID: O60242

Source protein: Adhesion G protein-coupled receptor B3

Source gene: ADGRB3

Class: DEG_ODPH_VHL_1

Location: 1367:1378

E3 ligase: VHL

DEGRON score: 0.644

ASA_SCORE: 93.0583

COIL: 0.8029

CONS_SCORE: 0.2953

DSS_SCORE: 0.5504

HELIX: 0.1758

FCONS_SCORE: 0.9758

RIG_SCORE: 0.7064

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F1359V	SIDM01954	Colorectal Carcinoma	GDSC	LAPQEHMQNLPF	DEG_ODPH_VHL_1	0.1111
p.A1368T	SIDM00958	Chronic Myelogenous Leukemia	GDSC	LAPQEHMQNLPF	DEG_ODPH_VHL_1	0.7139
p.A1368T	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	LAPQEHMQNLPF	DEG_ODPH_VHL_1	0.7139
p.N1362T	SIDM01197	Colorectal Carcinoma	GDSC	LAPQEHMQNLPF	DEG_ODPH_VHL_1	0.1944
p.N1362T	SNU-C1	large_intestine	COSMIC	LAPQEHMQNLPF	DEG_ODPH_VHL_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60242	Adhesion G protein-coupled receptor B3	DEG_ODPH_VHL_1	1367:1378	LAPQEHMQNLPF	VHL	0.644	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons