DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
NPEGLSYSTLP
Uniprot ID:
O60242
Source protein:
Adhesion G protein-coupled receptor B3
Source gene:
ADGRB3
Class:
CBL_PTK
Location:
1231:1241
E3 ligase:
CBL
DEGRON score:
0.997
ASA_SCORE:
71.9
COIL:
0.845
CONS_SCORE:
0.3062
DSS_SCORE:
0.5069
HELIX:
0.0444
FCONS_SCORE:
0.8898
RIG_SCORE:
0.6918
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.K1228N
NCI-H630
large_intestine
COSMIC
NPEGLSYSTLP
CBL_PTK
0.3611
Drug responses associated with ADGRB3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NPEGLSYSTLP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O60242
Adhesion G protein-coupled receptor B3
CBL_PTK
1231:1241
NPEGLSYSTLP
CBL
0.997
More...