DegronMD

Uniprot ID: O60242

Source protein: Adhesion G protein-coupled receptor B3

Source gene: ADGRB3

Class: DEG_SPOP_SBC_1

Location: 1455:1459

E3 ligase: SPOP

DEGRON score: 0.981

ASA_SCORE: 78.36

COIL: 0.9182

CONS_SCORE: 0.3466

DSS_SCORE: 0.6205

HELIX: 0.0622

FCONS_SCORE: 0.9845

RIG_SCORE: 0.6553

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1452W	SIDM01300	Colorectal Carcinoma	GDSC	PNTSS	DEG_SPOP_SBC_1	0.25
p.R1452W	SIDM00003	Melanoma	GDSC	PNTSS	DEG_SPOP_SBC_1	0.25
p.R1452W	M14	skin	COSMIC	PNTSS	DEG_SPOP_SBC_1	0.25
p.E1461K	SIDM00336	Melanoma	GDSC	PNTSS	DEG_SPOP_SBC_1	0.2778
p.E1461K	MEL-JUSO	skin	COSMIC	PNTSS	DEG_SPOP_SBC_1	0.2778
p.P1469S	SIDM01175	Other Sarcomas	GDSC	PNTSS	DEG_SPOP_SBC_1	0.0556
p.P1469S	SW684	soft_tissue	COSMIC	PNTSS	DEG_SPOP_SBC_1	0.0556
p.P1469L	SIDM01175	Other Sarcomas	GDSC	PNTSS	DEG_SPOP_SBC_1	0.0556
p.P1469L	SIDM00126	Melanoma	GDSC	PNTSS	DEG_SPOP_SBC_1	0.0556
p.P1469L	SW684	soft_tissue	COSMIC	PNTSS	DEG_SPOP_SBC_1	0.0556
p.P1469L	K2	skin	COSMIC	PNTSS	DEG_SPOP_SBC_1	0.0556
p.N1462T	HT	haematopoietic_and_lymphoid_tissue	COSMIC	PNTSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43314	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2	DEG_SPOP_SBC_1	1217:1221	PNTSS	SPOP	0.9788	More...
O60242	Adhesion G protein-coupled receptor B3	DEG_SPOP_SBC_1	1455:1459	PNTSS	SPOP	0.981	More...
P06213	Insulin receptor	DEG_SPOP_SBC_1	781:785	PNTSS	SPOP	0.9753	More...
Q17RS7	Flap endonuclease GEN homolog 1	DEG_SPOP_SBC_1	570:574	PNTSS	SPOP	0.7349	More...
Q9UN79	Transcription factor SOX-13	DEG_SPOP_SBC_1	305:309	PNTSS	SPOP	0.9656	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons