DegronMD

Uniprot ID: P06213

Source protein: Insulin receptor

Source gene: INSR

Class: DEG_SPOP_SBC_1

Location: 781:785

E3 ligase: SPOP

DEGRON score: 0.9753

ASA_SCORE: 76.12

COIL: 0.8756

CONS_SCORE: 0.2945

DSS_SCORE: 0.5556

HELIX: 0.047

FCONS_SCORE: 0.9268

RIG_SCORE: 0.6561

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T771A	TCGA-55-8506	LUAD	TCGA	PNTSS	DEG_SPOP_SBC_1	0.0556
p.S787I	TCGA-AA-3492	COAD	TCGA	PNTSS	DEG_SPOP_SBC_1	0.2778
p.A778T	TCGA-AP-A0LE	UCEC	TCGA	PNTSS	DEG_SPOP_SBC_1	0.25
p.T771M	TCGA-AX-A1C5	UCEC	TCGA	PNTSS	DEG_SPOP_SBC_1	0.0556
p.T776M	TCGA-BR-A4QL	STAD	TCGA	PNTSS	DEG_SPOP_SBC_1	0.1944
p.S785L	TCGA-EE-A29D	SKCM	TCGA	PNTSS	DEG_SPOP_SBC_1	0.7667
p.P781L	TCGA-EE-A2MU	SKCM	TCGA	PNTSS	DEG_SPOP_SBC_1	0.7582
p.R784M	DO9346	COAD	ICGC	PNTSS	DEG_SPOP_SBC_1	0.8632
p.S775I	DO8224	COAD	ICGC	PNTSS	DEG_SPOP_SBC_1	0.1667
p.T771N	DO229027	LICA	ICGC	PNTSS	DEG_SPOP_SBC_1	0.0556
p.P785T	DO50974	LICA	ICGC	PNTSS	DEG_SPOP_SBC_1	0.7031
p.P785L	DO50974	LICA	ICGC	PNTSS	DEG_SPOP_SBC_1	0.7582
p.P785S	DO47636	SKCM	ICGC	PNTSS	DEG_SPOP_SBC_1	0.6752
p.S773L	DO38123	SKCM	ICGC	PNTSS	DEG_SPOP_SBC_1	0.1111
p.P792L	SIDM01104	Melanoma	GDSC	PNTSS	DEG_SPOP_SBC_1	0.1389
p.P792L	ACH-000640	Skin Cancer	CCLE	PNTSS	DEG_SPOP_SBC_1	0.1389
p.P792L	SK-MEL-31	skin	COSMIC	PNTSS	DEG_SPOP_SBC_1	0.1389
p.S785W	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	PNTSS	DEG_SPOP_SBC_1	0.7874
p.S785W	ACH-002215	Lymphoma	CCLE	PNTSS	DEG_SPOP_SBC_1	0.7874
p.S785W	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	PNTSS	DEG_SPOP_SBC_1	0.7874
p.V774M	SIDM00782	Colorectal Carcinoma	GDSC	PNTSS	DEG_SPOP_SBC_1	0.1389
p.V774M	T84	large_intestine	COSMIC	PNTSS	DEG_SPOP_SBC_1	0.1389
p.K792R	A427	lung	COSMIC	PNTSS	DEG_SPOP_SBC_1	0.1389
p.S773W	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	PNTSS	DEG_SPOP_SBC_1	0.1111
p.P780L	SK-MEL-31	skin	COSMIC	PNTSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43314	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2	DEG_SPOP_SBC_1	1217:1221	PNTSS	SPOP	0.9788	More...
O60242	Adhesion G protein-coupled receptor B3	DEG_SPOP_SBC_1	1455:1459	PNTSS	SPOP	0.981	More...
P06213	Insulin receptor	DEG_SPOP_SBC_1	781:785	PNTSS	SPOP	0.9753	More...
Q17RS7	Flap endonuclease GEN homolog 1	DEG_SPOP_SBC_1	570:574	PNTSS	SPOP	0.7349	More...
Q9UN79	Transcription factor SOX-13	DEG_SPOP_SBC_1	305:309	PNTSS	SPOP	0.9656	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons