DegronMD

Uniprot ID: Q17RS7

Source protein: Flap endonuclease GEN homolog 1

Source gene: GEN1

Class: DEG_SPOP_SBC_1

Location: 570:574

E3 ligase: SPOP

DEGRON score: 0.7349

ASA_SCORE: 81.14

COIL: 0.8726

CONS_SCORE: 0.3161

DSS_SCORE: 0.383

HELIX: 0.1008

FCONS_SCORE: 0.8975

RIG_SCORE: 0.6173

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I577M	TCGA-A5-A0VQ	UCEC	TCGA	PNTSS	DEG_SPOP_SBC_1	0.25
p.I577M	DO42113	UCEC	ICGC	PNTSS	DEG_SPOP_SBC_1	0.25
p.S574Y	TCGA-AP-A1E0	UCEC	TCGA	PNTSS	DEG_SPOP_SBC_1	0.712
p.S574Y	DO43154	UCEC	ICGC	PNTSS	DEG_SPOP_SBC_1	0.712
p.L583I	TCGA-DK-A2I2	BLCA	TCGA	PNTSS	DEG_SPOP_SBC_1	0.0833
p.L583I	DO708	BLCA	ICGC	PNTSS	DEG_SPOP_SBC_1	0.0833
p.I564F	DO222477	ESCA	ICGC	PNTSS	DEG_SPOP_SBC_1	0.1667
p.V579L	DO229032	LICA	ICGC	PNTSS	DEG_SPOP_SBC_1	0.1944
p.I564T	DO231176	LUSC	ICGC	PNTSS	DEG_SPOP_SBC_1	0.1667
p.S560N	SIDM01652	Non-Cancerous	GDSC	PNTSS	DEG_SPOP_SBC_1	0.0556
p.S560N	SIDM00187	Kidney Carcinoma	GDSC	PNTSS	DEG_SPOP_SBC_1	0.0556
p.S560N	ACH-002352	Non-Cancerous	CCLE	PNTSS	DEG_SPOP_SBC_1	0.0556
p.N571S	SIDM00202	Ewing's Sarcoma	GDSC	PNTSS	DEG_SPOP_SBC_1	0.5958
p.N571S	ACH-002118	Bone Cancer	CCLE	PNTSS	DEG_SPOP_SBC_1	0.5958
p.N571S	EW-3	bone	COSMIC	PNTSS	DEG_SPOP_SBC_1	0.5958
p.K561E	SIDM01045	Endometrial Carcinoma	GDSC	PNTSS	DEG_SPOP_SBC_1	0.1944
p.K561E	ACH-000978	Endometrial/Uterine Cancer	CCLE	PNTSS	DEG_SPOP_SBC_1	0.1944
p.K561E	EN	endometrium	COSMIC	PNTSS	DEG_SPOP_SBC_1	0.1944
p.S567C	ACH-001411	Bladder Cancer	CCLE	PNTSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43314	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2	DEG_SPOP_SBC_1	1217:1221	PNTSS	SPOP	0.9788	More...
O60242	Adhesion G protein-coupled receptor B3	DEG_SPOP_SBC_1	1455:1459	PNTSS	SPOP	0.981	More...
P06213	Insulin receptor	DEG_SPOP_SBC_1	781:785	PNTSS	SPOP	0.9753	More...
Q17RS7	Flap endonuclease GEN homolog 1	DEG_SPOP_SBC_1	570:574	PNTSS	SPOP	0.7349	More...
Q9UN79	Transcription factor SOX-13	DEG_SPOP_SBC_1	305:309	PNTSS	SPOP	0.9656	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons