DegronMD - Q9UN79(SOX13)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R391L	TCGA-2G-AAL5	TGCT	TCGA	FRKDLISLD	DEG_APCC_DBOX_1	376:384	Mutation rewiring degron network	0.1389
p.M315I	TCGA-63-A5MT	LUSC	TCGA	PNTSS	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.1667
p.M315I	DO219163	LUSC	ICGC	PNTSS	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.1667
p.A301D	TCGA-AN-A0AT	BRCA	TCGA	PNTSS	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.2222
p.A301D	DO2783	BRCA	ICGC	PNTSS	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.2222
p.S382I	TCGA-CV-A45Z	HNSC	TCGA	FRKDLISLD	DEG_APCC_DBOX_1	376:384	Mutation altering degron motif	0.7341
p.S382I	DO52064	HNSC	ICGC	FRKDLISLD	DEG_APCC_DBOX_1	376:384	Mutation altering degron motif	0.7341
p.F376L	TCGA-D3-A8GC	SKCM	TCGA	FRKDLISLD	DEG_APCC_DBOX_1	376:384	Mutation altering degron motif	0.587
p.F376L	DO50281	SKCM	ICGC	FRKDLISLD	DEG_APCC_DBOX_1	376:384	Mutation altering degron motif	0.587
p.R377C	TCGA-D3-A8GC	SKCM	TCGA	FRKDLISLD	DEG_APCC_DBOX_1	376:384	Mutation altering degron motif	0.8301
p.R377C	DO50281	SKCM	ICGC	FRKDLISLD	DEG_APCC_DBOX_1	376:384	Mutation altering degron motif	0.8301
p.E390K	TCGA-JY-A6FE	ESCA	TCGA	FRKDLISLD	DEG_APCC_DBOX_1	376:384	Mutation rewiring degron network	0.1667
p.R391W	TCGA-QS-A5YR	UCEC	TCGA	FRKDLISLD	DEG_APCC_DBOX_1	376:384	Mutation rewiring degron network	0.1389
p.R391W	DO222492	COCA	ICGC	FRKDLISLD	DEG_APCC_DBOX_1	376:384	Mutation rewiring degron network	0.1389
p.R391W	DO50081	UCEC	ICGC	FRKDLISLD	DEG_APCC_DBOX_1	376:384	Mutation rewiring degron network	0.1389
p.P299L	DO222794	COCA	ICGC	PNTSS	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.1667
p.R377H	DO50385	ESAD	ICGC	FRKDLISLD	DEG_APCC_DBOX_1	376:384	Mutation altering degron motif	0.8244
p.S371F	DO223046	ESCA	ICGC	FRKDLISLD	DEG_APCC_DBOX_1	376:384	Mutation blocking phosphorylation signal	0.6389
p.K298N	DO229037	LICA	ICGC	PNTSS	DEG_SPOP_SBC_1	305:309	Mutation substituting flanking lysine	0.25
p.E303K	SIDM00627	Cervical Carcinoma	GDSC	PNTSS	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.2778
p.E303K	ME-180	cervix	COSMIC	PNTSS	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.2778
p.S312I	ACH-000954	Endometrial/Uterine Cancer	CCLE	PNTSS	DEG_SPOP_SBC_1	305:309	Mutation blocking phosphorylation signal	0.6944
p.P372L	ACH-001147	Lymphoma	CCLE	FRKDLISLD	DEG_APCC_DBOX_1	376:384	Mutation rewiring degron network	0.2222

Kaplan plot for SOX13 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SOX13

UniProt ID: Q9UN79

Entrez ID: 9580

Protein name: Transcription factor SOX-13 (Islet cell antigen 12) (SRY (Sex determining region Y)-box 13) (Type 1 diabetes autoantigen ICA12)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SOX13 in