DegronMD

Uniprot ID: Q9UN79

Source protein: Transcription factor SOX-13

Source gene: SOX13

Class: DEG_APCC_DBOX_1

Location: 376:384

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9972

ASA_SCORE: 96.2222

COIL: 0.7579

CONS_SCORE: 0.4135

DSS_SCORE: 0.5355

HELIX: 0.2033

FCONS_SCORE: 1.0963

RIG_SCORE: 0.7281

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R391L	TCGA-2G-AAL5	TGCT	TCGA	FRKDLISLD	DEG_APCC_DBOX_1	0.1389
p.S382I	TCGA-CV-A45Z	HNSC	TCGA	FRKDLISLD	DEG_APCC_DBOX_1	0.7341
p.S382I	DO52064	HNSC	ICGC	FRKDLISLD	DEG_APCC_DBOX_1	0.7341
p.F376L	TCGA-D3-A8GC	SKCM	TCGA	FRKDLISLD	DEG_APCC_DBOX_1	0.587
p.F376L	DO50281	SKCM	ICGC	FRKDLISLD	DEG_APCC_DBOX_1	0.587
p.R377C	TCGA-D3-A8GC	SKCM	TCGA	FRKDLISLD	DEG_APCC_DBOX_1	0.8301
p.R377C	DO50281	SKCM	ICGC	FRKDLISLD	DEG_APCC_DBOX_1	0.8301
p.E390K	TCGA-JY-A6FE	ESCA	TCGA	FRKDLISLD	DEG_APCC_DBOX_1	0.1667
p.R391W	TCGA-QS-A5YR	UCEC	TCGA	FRKDLISLD	DEG_APCC_DBOX_1	0.1389
p.R391W	DO222492	COCA	ICGC	FRKDLISLD	DEG_APCC_DBOX_1	0.1389
p.R391W	DO50081	UCEC	ICGC	FRKDLISLD	DEG_APCC_DBOX_1	0.1389
p.R377H	DO50385	ESAD	ICGC	FRKDLISLD	DEG_APCC_DBOX_1	0.8244
p.S371F	DO223046	ESCA	ICGC	FRKDLISLD	DEG_APCC_DBOX_1	0.6389
p.P372L	ACH-001147	Lymphoma	CCLE	FRKDLISLD	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UN79	Transcription factor SOX-13	DEG_APCC_DBOX_1	376:384	FRKDLISLD	APC,CDC20,FZR1	0.9972	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons