DegronMD

Uniprot ID: Q9UN79

Source protein: Transcription factor SOX-13

Source gene: SOX13

Class: DEG_SPOP_SBC_1

Location: 305:309

E3 ligase: SPOP

DEGRON score: 0.9656

ASA_SCORE: 81.94

COIL: 0.9396

CONS_SCORE: 0.4303

DSS_SCORE: 0.7173

HELIX: 0.0356

FCONS_SCORE: 0.9293

RIG_SCORE: 0.5485

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M315I	TCGA-63-A5MT	LUSC	TCGA	PNTSS	DEG_SPOP_SBC_1	0.1667
p.M315I	DO219163	LUSC	ICGC	PNTSS	DEG_SPOP_SBC_1	0.1667
p.A301D	TCGA-AN-A0AT	BRCA	TCGA	PNTSS	DEG_SPOP_SBC_1	0.2222
p.A301D	DO2783	BRCA	ICGC	PNTSS	DEG_SPOP_SBC_1	0.2222
p.P299L	DO222794	COCA	ICGC	PNTSS	DEG_SPOP_SBC_1	0.1667
p.K298N	DO229037	LICA	ICGC	PNTSS	DEG_SPOP_SBC_1	0.25
p.E303K	SIDM00627	Cervical Carcinoma	GDSC	PNTSS	DEG_SPOP_SBC_1	0.2778
p.E303K	ME-180	cervix	COSMIC	PNTSS	DEG_SPOP_SBC_1	0.2778
p.S312I	ACH-000954	Endometrial/Uterine Cancer	CCLE	PNTSS	DEG_SPOP_SBC_1	0.6944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43314	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2	DEG_SPOP_SBC_1	1217:1221	PNTSS	SPOP	0.9788	More...
O60242	Adhesion G protein-coupled receptor B3	DEG_SPOP_SBC_1	1455:1459	PNTSS	SPOP	0.981	More...
P06213	Insulin receptor	DEG_SPOP_SBC_1	781:785	PNTSS	SPOP	0.9753	More...
Q17RS7	Flap endonuclease GEN homolog 1	DEG_SPOP_SBC_1	570:574	PNTSS	SPOP	0.7349	More...
Q9UN79	Transcription factor SOX-13	DEG_SPOP_SBC_1	305:309	PNTSS	SPOP	0.9656	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons