DegronMD - O15151(MDM4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V371I	TCGA-AA-A010	COAD	TCGA	KKENS	DEG_APCC_KENBOX_2	379:383	Mutation rewiring degron network	0.1111
p.V371I	TCGA-CG-5728	STAD	TCGA	KKENS	DEG_APCC_KENBOX_2	379:383	Mutation rewiring degron network	0.1111
p.E393G	TCGA-AP-A059	UCEC	TCGA	KKENS	DEG_APCC_KENBOX_2	379:383	Mutation rewiring degron network	0.0556
p.E393G	DO41361	UCEC	ICGC	KKENS	DEG_APCC_KENBOX_2	379:383	Mutation rewiring degron network	0.0556
p.E381D	TCGA-B5-A1MR	UCEC	TCGA	KKENS	DEG_APCC_KENBOX_2	379:383	Mutation altering degron motif	0.6758
p.P369S	TCGA-D6-6516	HNSC	TCGA	KKENS	DEG_APCC_KENBOX_2	379:383	Mutation rewiring degron network	0.0556
p.P369S	DO15623	HNSC	ICGC	KKENS	DEG_APCC_KENBOX_2	379:383	Mutation rewiring degron network	0.0556
p.L383I	DO13863	GBM	ICGC	KKENS	DEG_APCC_KENBOX_2	379:383	Mutation altering degron motif	0.7174
p.L383F	DO220859	MELA	ICGC	KKENS	DEG_APCC_KENBOX_2	379:383	Mutation altering degron motif	0.6981
p.D375G	SIDM01058	B-Cell Non-Hodgkin's Lymphoma	GDSC	KKENS	DEG_APCC_KENBOX_2	379:383	Mutation rewiring degron network	0.2222
p.D375G	ACH-000073	Lymphoma	CCLE	KKENS	DEG_APCC_KENBOX_2	379:383	Mutation rewiring degron network	0.2222
p.D375G	GRANTA-519	haematopoietic and lymphoid tissue	COSMIC	KKENS	DEG_APCC_KENBOX_2	379:383	Mutation rewiring degron network	0.2222
p.D375Y	SIDM01058	B-Cell Non-Hodgkin's Lymphoma	GDSC	KKENS	DEG_APCC_KENBOX_2	379:383	Mutation rewiring degron network	0.2222
p.D375Y	GRANTA-519	haematopoietic and lymphoid tissue	COSMIC	KKENS	DEG_APCC_KENBOX_2	379:383	Mutation rewiring degron network	0.2222
p.P388A	SIDM00857	Melanoma	GDSC	KKENS	DEG_APCC_KENBOX_2	379:383	Mutation rewiring degron network	0.1944
p.P388A	SIDM00885	Breast Carcinoma	GDSC	KKENS	DEG_APCC_KENBOX_2	379:383	Mutation rewiring degron network	0.1944
p.P388A	SIDM00057	Neuroblastoma	GDSC	KKENS	DEG_APCC_KENBOX_2	379:383	Mutation rewiring degron network	0.1944
p.P388A	SIDM00210	Ovarian Carcinoma	GDSC	KKENS	DEG_APCC_KENBOX_2	379:383	Mutation rewiring degron network	0.1944
p.P388A	SIDM00869	Non-Cancerous	GDSC	KKENS	DEG_APCC_KENBOX_2	379:383	Mutation rewiring degron network	0.1944
p.P388A	SIDM00145	T-Lymphoblastic Leukemia	GDSC	KKENS	DEG_APCC_KENBOX_2	379:383	Mutation rewiring degron network	0.1944
p.P388A	SIDM00153	T-Lymphoblastic Leukemia	GDSC	KKENS	DEG_APCC_KENBOX_2	379:383	Mutation rewiring degron network	0.1944
p.P388A	SIDM01761	Rhabdomyosarcoma	GDSC	KKENS	DEG_APCC_KENBOX_2	379:383	Mutation rewiring degron network	0.1944
p.K384E	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	KKENS	DEG_APCC_KENBOX_2	379:383	Mutation blocking ubiquitination signal	0.75
p.K384E	ACH-000444	Lung Cancer	CCLE	KKENS	DEG_APCC_KENBOX_2	379:383	Mutation blocking ubiquitination signal	0.75
p.K384E	LU-99A	lung	COSMIC	KKENS	DEG_APCC_KENBOX_2	379:383	Mutation blocking ubiquitination signal	0.75
p.C389R	SIDM00333	Endometrial Carcinoma	GDSC	KKENS	DEG_APCC_KENBOX_2	379:383	Mutation rewiring degron network	0.1667
p.C389R	MFE-319	endometrium	COSMIC	KKENS	DEG_APCC_KENBOX_2	379:383	Mutation rewiring degron network	0.1667
p.A376E	SIDM01608	Endometrial Carcinoma	GDSC	KKENS	DEG_APCC_KENBOX_2	379:383	Mutation rewiring degron network	0.25
p.A376E	ACH-000990	Endometrial/Uterine Cancer	CCLE	KKENS	DEG_APCC_KENBOX_2	379:383	Mutation rewiring degron network	0.25
p.D375C	ACH-000073	Lymphoma	CCLE	KKENS	DEG_APCC_KENBOX_2	379:383	Mutation rewiring degron network	0.2222
p.C389G	ACH-000261	Lung Cancer	CCLE	KKENS	DEG_APCC_KENBOX_2	379:383	Mutation rewiring degron network	0.1667
p.C389G	ACH-002122	Lung Cancer	CCLE	KKENS	DEG_APCC_KENBOX_2	379:383	Mutation rewiring degron network	0.1667
p.T372I	NCI-H1155	lung	COSMIC	KKENS	DEG_APCC_KENBOX_2	379:383	Mutation rewiring degron network	0.1389
p.M377I	Jurkat	haematopoietic and lymphoid tissue	COSMIC	KKENS	DEG_APCC_KENBOX_2	379:383	Mutation rewiring degron network	0.2778

Kaplan plot for MDM4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MDM4

UniProt ID: O15151

Entrez ID: 4194

Protein name: Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MDM4 in