DegronMD

Uniprot ID: P56715

Source protein: Oxygen-regulated protein 1

Source gene: RP1

Class: DEG_APCC_KENBOX_2

Location: 534:538

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6968

ASA_SCORE: 123.16

COIL: 0.4232

CONS_SCORE: 0.475

DSS_SCORE: 0.4802

HELIX: 0.566

FCONS_SCORE: 1.0772

RIG_SCORE: 0.7285

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D524E	TCGA-44-2656	LUAD	TCGA	KKENS	DEG_APCC_KENBOX_2	0.0556
p.D524E	DO26052	LUAD	ICGC	KKENS	DEG_APCC_KENBOX_2	0.0556
p.L531F	TCGA-49-AAR4	LUAD	TCGA	KKENS	DEG_APCC_KENBOX_2	0.25
p.L531F	DO218920	LUAD	ICGC	KKENS	DEG_APCC_KENBOX_2	0.25
p.R533I	TCGA-55-7911	LUAD	TCGA	KKENS	DEG_APCC_KENBOX_2	0.3056
p.R533I	DO24821	LUAD	ICGC	KKENS	DEG_APCC_KENBOX_2	0.3056
p.Q525E	TCGA-61-1727	OV	TCGA	KKENS	DEG_APCC_KENBOX_2	0.0833
p.Q525E	DO29960	OV	ICGC	KKENS	DEG_APCC_KENBOX_2	0.0833
p.K534E	TCGA-D3-A8GI	SKCM	TCGA	KKENS	DEG_APCC_KENBOX_2	0.591
p.K534E	DO50284	SKCM	ICGC	KKENS	DEG_APCC_KENBOX_2	0.591
p.E536K	TCGA-EE-A2A2	SKCM	TCGA	KKENS	DEG_APCC_KENBOX_2	0.7022
p.E536K	TCGA-EE-A3JD	SKCM	TCGA	KKENS	DEG_APCC_KENBOX_2	0.7022
p.E536K	DO220902	MELA	ICGC	KKENS	DEG_APCC_KENBOX_2	0.7022
p.E536K	DO37583	SKCM	ICGC	KKENS	DEG_APCC_KENBOX_2	0.7022
p.E536K	DO50299	SKCM	ICGC	KKENS	DEG_APCC_KENBOX_2	0.7022
p.S530L	TCGA-EE-A2MC	SKCM	TCGA	KKENS	DEG_APCC_KENBOX_2	0.2222
p.S530L	DO37559	SKCM	ICGC	KKENS	DEG_APCC_KENBOX_2	0.2222
p.N537K	DO233000	GACA	ICGC	KKENS	DEG_APCC_KENBOX_2	0.6918
p.S542P	SIDM00901	Endometrial Carcinoma	GDSC	KKENS	DEG_APCC_KENBOX_2	0.2222
p.S542P	ACH-000940	Endometrial/Uterine Cancer	CCLE	KKENS	DEG_APCC_KENBOX_2	0.2222
p.S542P	AN3-CA	endometrium	COSMIC	KKENS	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15151	Protein Mdm4	DEG_APCC_KENBOX_2	379:383	KKENS	APC,CDC20,FZR1	0.6013	More...
O60242	Adhesion G protein-coupled receptor B3	DEG_APCC_KENBOX_2	1271:1275	KKENS	APC,CDC20,FZR1	0.6429	More...
P29965	CD40 ligand	DEG_APCC_KENBOX_2	106:110	KKENS	APC,CDC20,FZR1	0.7872	More...
P56715	Oxygen-regulated protein 1	DEG_APCC_KENBOX_2	534:538	KKENS	APC,CDC20,FZR1	0.6968	More...
P98082	Disabled homolog 2	DEG_APCC_KENBOX_2	320:324	KKENS	APC,CDC20,FZR1	0.6959	More...
Q7Z2Z1	Treslin	DEG_APCC_KENBOX_2	887:891	KKENS	APC,CDC20,FZR1	0.9836	More...
Q9GZS3	WD repeat-containing protein 61	DEG_APCC_KENBOX_2	28:32	KKENS	APC,CDC20,FZR1	0.5187	More...
Q9NQW8	Cyclic nucleotide-gated cation channel beta-3	DEG_APCC_KENBOX_2	702:706	KKENS	APC,CDC20,FZR1	0.5372	More...
O00515	Ladinin-1	DEG_APCC_KENBOX_2	381:385	KKENS	APC,CDC20,FZR1	0.9602	More...
Q9BY89	Uncharacterized protein KIAA1671	DEG_APCC_KENBOX_2	669:673	KKENS	APC,CDC20,FZR1	0.7067	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons