DegronMD

Uniprot ID: Q7Z2Z1

Source protein: Treslin

Source gene: TICRR

Class: DEG_SCF_FBW7_1

Location: 1128:1134

E3 ligase: FBXW7

DEGRON score: 0.9983

ASA_SCORE: 103.8571

COIL: 0.9621

CONS_SCORE: 0.4749

DSS_SCORE: 0.7408

HELIX: 0.0136

FCONS_SCORE: 1.339

RIG_SCORE: 0.6779

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1131L	TCGA-3B-A9HT	SARC	TCGA	PQTPLYT	DEG_SCF_FBW7_1	0.7582
p.P1131L	TCGA-BH-A0H5	BRCA	TCGA	PQTPLYT	DEG_SCF_FBW7_1	0.7582
p.P1131L	TCGA-IB-7651	PAAD	TCGA	PQTPLYT	DEG_SCF_FBW7_1	0.7582
p.P1131L	DO5207	BRCA	ICGC	PQTPLYT	DEG_SCF_FBW7_1	0.7582
p.P1131L	DO46657	PAAD	ICGC	PQTPLYT	DEG_SCF_FBW7_1	0.7582
p.P1131L	DO219934	SARC	ICGC	PQTPLYT	DEG_SCF_FBW7_1	0.7582
p.P1121A	TCGA-55-A491	LUAD	TCGA	PQTPLYT	DEG_SCF_FBW7_1	0.1389
p.P1121A	DO25787	LUAD	ICGC	PQTPLYT	DEG_SCF_FBW7_1	0.1389
p.P1121A	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	PQTPLYT	DEG_SCF_FBW7_1	0.1389
p.P1121A	ACH-000727	Lung Cancer	CCLE	PQTPLYT	DEG_SCF_FBW7_1	0.1389
p.P1121A	NCI-H2066	lung	COSMIC	PQTPLYT	DEG_SCF_FBW7_1	0.1389
p.S1125C	TCGA-AC-A23H	BRCA	TCGA	PQTPLYT	DEG_SCF_FBW7_1	0.6944
p.S1125C	DO2401	BRCA	ICGC	PQTPLYT	DEG_SCF_FBW7_1	0.6944
p.I1124M	TCGA-E5-A4TZ	BLCA	TCGA	PQTPLYT	DEG_SCF_FBW7_1	0.2222
p.I1124M	DO44055	BLCA	ICGC	PQTPLYT	DEG_SCF_FBW7_1	0.2222
p.E1136Q	TCGA-ZJ-A8QR	CESC	TCGA	PQTPLYT	DEG_SCF_FBW7_1	0.2778
p.E1136Q	DO219749	CESC	ICGC	PQTPLYT	DEG_SCF_FBW7_1	0.2778
p.P1142L	SIDM00321	Ovarian Carcinoma	GDSC	PQTPLYT	DEG_SCF_FBW7_1	0.1111
p.P1142L	ACH-000430	Ovarian Cancer	CCLE	PQTPLYT	DEG_SCF_FBW7_1	0.1111
p.P1142L	TYK-nu	ovary	COSMIC	PQTPLYT	DEG_SCF_FBW7_1	0.1111
p.T1127I	SIDM00216	Colorectal Carcinoma	GDSC	PQTPLYT	DEG_SCF_FBW7_1	0.75
p.T1127I	SNU-175	large_intestine	COSMIC	PQTPLYT	DEG_SCF_FBW7_1	0.75
p.K1140N	SIDM00457	Plasma Cell Myeloma	GDSC	PQTPLYT	DEG_SCF_FBW7_1	0.2778
p.K1140N	ACH-000024	Myeloma	CCLE	PQTPLYT	DEG_SCF_FBW7_1	0.2778
p.K1140N	ACH-000057	Myeloma	CCLE	PQTPLYT	DEG_SCF_FBW7_1	0.2778
p.K1140N	OPM-2	haematopoietic_and_lymphoid_tissue	COSMIC	PQTPLYT	DEG_SCF_FBW7_1	0.2778
p.T1126I	SNU-175	large_intestine	COSMIC	PQTPLYT	DEG_SCF_FBW7_1	0.2778
p.P1120A	NCI-H2066	lung	COSMIC	PQTPLYT	DEG_SCF_FBW7_1	0.5556
p.P1141L	TYK-nu	ovary	COSMIC	PQTPLYT	DEG_SCF_FBW7_1	0.5833
p.K1139N	OPM-2	haematopoietic_and_lymphoid_tissue	COSMIC	PQTPLYT	DEG_SCF_FBW7_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PQTPLYT

Degron related mutations and impact score

Drug responses associated with TICRR mutations

All proteins holding degron of PQTPLYT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z2Z1	Treslin	DEG_SCF_FBW7_1	1128:1134	PQTPLYT	FBXW7	0.9983	More...