DegronMD

Uniprot ID: Q7Z2Z1

Source protein: Treslin

Source gene: TICRR

Class: DEG_APCC_DBOX_1

Location: 1366:1374

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9653

ASA_SCORE: 112.1

COIL: 0.9289

CONS_SCORE: 0.3087

DSS_SCORE: 0.7465

HELIX: 0.0536

FCONS_SCORE: 0.8112

RIG_SCORE: 0.6388

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1362S	TCGA-D6-6516	HNSC	TCGA	QRATLDTVP	DEG_APCC_DBOX_1	0.2222
p.P1362S	DO15623	HNSC	ICGC	QRATLDTVP	DEG_APCC_DBOX_1	0.2222
p.K1383N	TCGA-D8-A1Y3	BRCA	TCGA	QRATLDTVP	DEG_APCC_DBOX_1	0.1944
p.K1383N	DO3107	BRCA	ICGC	QRATLDTVP	DEG_APCC_DBOX_1	0.1944
p.T1360A	TCGA-G4-6588	COAD	TCGA	QRATLDTVP	DEG_APCC_DBOX_1	0.6111
p.T1360A	DO10140	COAD	ICGC	QRATLDTVP	DEG_APCC_DBOX_1	0.6111
p.V1373I	DO229013	COCA	ICGC	QRATLDTVP	DEG_APCC_DBOX_1	0.5965
p.V1373I	DO229003	COCA	ICGC	QRATLDTVP	DEG_APCC_DBOX_1	0.5965
p.A1368S	DO228952	LICA	ICGC	QRATLDTVP	DEG_APCC_DBOX_1	0.6477
p.R1384Q	SIDM00921	Non-Small Cell Lung Carcinoma	GDSC	QRATLDTVP	DEG_APCC_DBOX_1	0.0556
p.R1384W	ACH-001862	Bile Duct Cancer	CCLE	QRATLDTVP	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z2Z1	Treslin	DEG_APCC_DBOX_1	1366:1374	QRATLDTVP	APC,CDC20,FZR1	0.9653	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons