DegronMD - Q6XYQ8(SYT10)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V124I	TCGA-17-Z022	LUAD	TCGA	IKENE	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.2222
p.T166K	TCGA-43-6771	LUSC	TCGA	PTSST	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.6195
p.T166K	DO26443	LUSC	ICGC	PTSST	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.6195
p.E164K	TCGA-4Z-AA7R	BLCA	TCGA	PTSST	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.3056
p.E164K	TCGA-NC-A5HL	LUSC	TCGA	PTSST	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.3056
p.E164K	DO51866	BLCA	ICGC	PTSST	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.3056
p.E164K	DO219193	LUSC	ICGC	PTSST	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.3056
p.R157L	TCGA-53-7626	LUAD	TCGA	PTSST	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1111
p.R157L	DO23774	LUAD	ICGC	PTSST	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1111
p.K117T	TCGA-78-7159	LUAD	TCGA	IKENE	DEG_APCC_KENBOX_2	116:120	Mutation altering degron motif	0.7306
p.K117T	DO23568	LUAD	ICGC	IKENE	DEG_APCC_KENBOX_2	116:120	Mutation altering degron motif	0.7306
p.L178M	TCGA-94-8490	LUSC	TCGA	PTSST	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0833
p.L178M	DO52021	LUSC	ICGC	PTSST	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0833
p.R157H	TCGA-A5-A0G2	UCEC	TCGA	PTSST	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1111
p.R157H	DO41235	UCEC	ICGC	PTSST	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1111
p.S167P	TCGA-AJ-A3EL	UCEC	TCGA	PTSST	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.6752
p.S167P	DO41542	UCEC	ICGC	PTSST	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.6752
p.A126S	TCGA-BP-4770	KIRC	TCGA	IKENE	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.1667
p.A126S	DO17779	KIRC	ICGC	IKENE	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.1667
p.P165H	TCGA-D1-A103	UCEC	TCGA	PTSST	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.7694
p.P165H	DO42312	UCEC	ICGC	PTSST	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.7694
p.E115D	TCGA-D3-A2JA	SKCM	TCGA	IKENE	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.3056
p.E115D	DO47652	SKCM	ICGC	IKENE	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.3056
p.S173F	TCGA-D3-A8GN	SKCM	TCGA	PTSST	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.2222
p.S173F	TCGA-EE-A3J5	SKCM	TCGA	PTSST	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.2222
p.S173F	TCGA-GN-A26C	SKCM	TCGA	PTSST	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.2222
p.S173F	DO37782	SKCM	ICGC	PTSST	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.2222
p.S173F	DO47331	SKCM	ICGC	PTSST	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.2222
p.S173F	DO51240	SKCM	ICGC	PTSST	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.2222
p.S173F	SIDM01240	Melanoma	GDSC	PTSST	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.2222
p.S173F	ACH-001002	Skin Cancer	CCLE	PTSST	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.2222
p.S173F	451Lu	skin	COSMIC	PTSST	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.2222
p.A126D	TCGA-DX-A6YT	SARC	TCGA	IKENE	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.1667
p.A126D	DO220007	SARC	ICGC	IKENE	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.1667
p.E128G	TCGA-EE-A29G	SKCM	TCGA	IKENE	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.1111
p.E128G	DO47303	SKCM	ICGC	IKENE	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.1111
p.E118K	TCGA-EE-A2M5	SKCM	TCGA	IKENE	DEG_APCC_KENBOX_2	116:120	Mutation altering degron motif	0.7022
p.E118K	DO220899	MELA	ICGC	IKENE	DEG_APCC_KENBOX_2	116:120	Mutation altering degron motif	0.7022
p.E118K	DO37425	SKCM	ICGC	IKENE	DEG_APCC_KENBOX_2	116:120	Mutation altering degron motif	0.7022
p.E128A	TCGA-MQ-A4LP	MESO	TCGA	IKENE	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.1111
p.E115K	TCGA-YG-AA3N	SKCM	TCGA	IKENE	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.3056
p.E115K	DO51298	SKCM	ICGC	IKENE	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.3056
p.R175Q	DO234462	ESAD	ICGC	PTSST	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1667
p.P179L	DO233030	GACA	ICGC	PTSST	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0556
p.P179L	DO50858	LICA	ICGC	PTSST	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0556
p.E106D	DO233906	GACA	ICGC	IKENE	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.0556
p.A156E	DO229027	LICA	ICGC	PTSST	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0833
p.H155N	DO229037	LICA	ICGC	PTSST	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0556
p.F174L	DO50813	LIRI	ICGC	PTSST	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1944
p.S172I	SIDM00377	Other Sarcomas	GDSC	PTSST	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.25
p.S172I	SKN	soft tissue	COSMIC	PTSST	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.25
p.P122A	SIDM00352	Ovarian Carcinoma	GDSC	IKENE	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.2778
p.P122A	SIDM00491	Thyroid Gland Carcinoma	GDSC	IKENE	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.2778
p.P122A	SIDM00607	Glioblastoma	GDSC	IKENE	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.2778
p.P122A	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	IKENE	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.2778
p.P122A	SIDM00351	Oral Cavity Carcinoma	GDSC	IKENE	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.2778
p.P122A	SIDM00562	Breast Carcinoma	GDSC	IKENE	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.2778
p.P122A	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	IKENE	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.2778
p.P122A	SIDM00239	Kidney Carcinoma	GDSC	IKENE	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.2778
p.P122A	SIDM01018	Hodgkin's Lymphoma	GDSC	IKENE	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.2778
p.P122A	SIDM00381	Cervical Carcinoma	GDSC	IKENE	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.2778
p.P122A	SIDM00159	Biliary Tract Carcinoma	GDSC	IKENE	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.2778
p.P129L	SIDM00190	Melanoma	GDSC	IKENE	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.0833
p.P129L	ACH-002097	Skin Cancer	CCLE	IKENE	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.0833
p.P129L	CP66-MEL	skin	COSMIC	IKENE	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.0833
p.P179Q	ACH-001997	Bile Duct Cancer	CCLE	PTSST	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0556

Kaplan plot for SYT10 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SYT10

UniProt ID: Q6XYQ8

Entrez ID: 341359

Protein name: Synaptotagmin-10 (Synaptotagmin X) (SytX)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SYT10 in