DegronMD

Uniprot ID: Q6XYQ8

Source protein: Synaptotagmin-10

Source gene: SYT10

Class: DEG_APCC_KENBOX_2

Location: 116:120

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6234

ASA_SCORE: 102.96

COIL: 0.5566

CONS_SCORE: 0.3767

DSS_SCORE: 0.5194

HELIX: 0.4258

FCONS_SCORE: 1.1087

RIG_SCORE: 0.7414

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V124I	TCGA-17-Z022	LUAD	TCGA	IKENE	DEG_APCC_KENBOX_2	0.2222
p.K117T	TCGA-78-7159	LUAD	TCGA	IKENE	DEG_APCC_KENBOX_2	0.7306
p.K117T	DO23568	LUAD	ICGC	IKENE	DEG_APCC_KENBOX_2	0.7306
p.A126S	TCGA-BP-4770	KIRC	TCGA	IKENE	DEG_APCC_KENBOX_2	0.1667
p.A126S	DO17779	KIRC	ICGC	IKENE	DEG_APCC_KENBOX_2	0.1667
p.E115D	TCGA-D3-A2JA	SKCM	TCGA	IKENE	DEG_APCC_KENBOX_2	0.3056
p.E115D	DO47652	SKCM	ICGC	IKENE	DEG_APCC_KENBOX_2	0.3056
p.A126D	TCGA-DX-A6YT	SARC	TCGA	IKENE	DEG_APCC_KENBOX_2	0.1667
p.A126D	DO220007	SARC	ICGC	IKENE	DEG_APCC_KENBOX_2	0.1667
p.E128G	TCGA-EE-A29G	SKCM	TCGA	IKENE	DEG_APCC_KENBOX_2	0.1111
p.E128G	DO47303	SKCM	ICGC	IKENE	DEG_APCC_KENBOX_2	0.1111
p.E118K	TCGA-EE-A2M5	SKCM	TCGA	IKENE	DEG_APCC_KENBOX_2	0.7022
p.E118K	DO220899	MELA	ICGC	IKENE	DEG_APCC_KENBOX_2	0.7022
p.E118K	DO37425	SKCM	ICGC	IKENE	DEG_APCC_KENBOX_2	0.7022
p.E128A	TCGA-MQ-A4LP	MESO	TCGA	IKENE	DEG_APCC_KENBOX_2	0.1111
p.E115K	TCGA-YG-AA3N	SKCM	TCGA	IKENE	DEG_APCC_KENBOX_2	0.3056
p.E115K	DO51298	SKCM	ICGC	IKENE	DEG_APCC_KENBOX_2	0.3056
p.E106D	DO233906	GACA	ICGC	IKENE	DEG_APCC_KENBOX_2	0.0556
p.P122A	SIDM00352	Ovarian Carcinoma	GDSC	IKENE	DEG_APCC_KENBOX_2	0.2778
p.P122A	SIDM00491	Thyroid Gland Carcinoma	GDSC	IKENE	DEG_APCC_KENBOX_2	0.2778
p.P122A	SIDM00607	Glioblastoma	GDSC	IKENE	DEG_APCC_KENBOX_2	0.2778
p.P122A	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	IKENE	DEG_APCC_KENBOX_2	0.2778
p.P122A	SIDM00351	Oral Cavity Carcinoma	GDSC	IKENE	DEG_APCC_KENBOX_2	0.2778
p.P122A	SIDM00562	Breast Carcinoma	GDSC	IKENE	DEG_APCC_KENBOX_2	0.2778
p.P122A	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	IKENE	DEG_APCC_KENBOX_2	0.2778
p.P122A	SIDM00239	Kidney Carcinoma	GDSC	IKENE	DEG_APCC_KENBOX_2	0.2778
p.P122A	SIDM01018	Hodgkin's Lymphoma	GDSC	IKENE	DEG_APCC_KENBOX_2	0.2778
p.P122A	SIDM00381	Cervical Carcinoma	GDSC	IKENE	DEG_APCC_KENBOX_2	0.2778
p.P122A	SIDM00159	Biliary Tract Carcinoma	GDSC	IKENE	DEG_APCC_KENBOX_2	0.2778
p.P129L	SIDM00190	Melanoma	GDSC	IKENE	DEG_APCC_KENBOX_2	0.0833
p.P129L	ACH-002097	Skin Cancer	CCLE	IKENE	DEG_APCC_KENBOX_2	0.0833
p.P129L	CP66-MEL	skin	COSMIC	IKENE	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25054	Adenomatous polyposis coli protein	DEG_APCC_KENBOX_2	2615:2619	IKENE	APC,CDC20,FZR1	0.9967	More...
Q6XYQ8	Synaptotagmin-10	DEG_APCC_KENBOX_2	116:120	IKENE	APC,CDC20,FZR1	0.6234	More...
Q9H2G2	STE20-like serine/threonine-protein kinase	DEG_APCC_KENBOX_2	419:423	IKENE	APC,CDC20,FZR1	0.6842	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IKENE

Degron related mutations and impact score

Drug responses associated with SYT10 mutations

All proteins holding degron of IKENE