DegronMD

Uniprot ID: P25054

Source protein: Adenomatous polyposis coli protein

Source gene: APC

Class: DEG_APCC_KENBOX_2

Location: 2615:2619

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9967

ASA_SCORE: 119.76

COIL: 0.8314

CONS_SCORE: 0.4117

DSS_SCORE: 0.5799

HELIX: 0.1314

FCONS_SCORE: 1.1632

RIG_SCORE: 0.7482

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2613I	TCGA-AJ-A3EL	UCEC	TCGA	IKENE	DEG_APCC_KENBOX_2	0.2778
p.R2613I	DO41542	UCEC	ICGC	IKENE	DEG_APCC_KENBOX_2	0.2778
p.N2624D	TCGA-B5-A0JY	UCEC	TCGA	IKENE	DEG_APCC_KENBOX_2	0.1944
p.N2624D	DO43041	UCEC	ICGC	IKENE	DEG_APCC_KENBOX_2	0.1944
p.S2621C	DO234285	ESAD	ICGC	IKENE	DEG_APCC_KENBOX_2	0.7222
p.S2625C	DO227891	PBCA	ICGC	IKENE	DEG_APCC_KENBOX_2	0.1667
p.E2617K	SIDM01045	Endometrial Carcinoma	GDSC	IKENE	DEG_APCC_KENBOX_2	0.7022
p.S2625I	SIDM00665	Gastric Carcinoma	GDSC	IKENE	DEG_APCC_KENBOX_2	0.1667
p.S2625I	ACH-000616	Gastric Cancer	CCLE	IKENE	DEG_APCC_KENBOX_2	0.1667
p.S2625I	Hs746T	stomach	COSMIC	IKENE	DEG_APCC_KENBOX_2	0.1667
p.E2617V	SIDM00954	Breast Carcinoma	GDSC	IKENE	DEG_APCC_KENBOX_2	0.7693
p.E2617V	ACH-001820	Breast Cancer	CCLE	IKENE	DEG_APCC_KENBOX_2	0.7693
p.E2617V	COLO-824	breast	COSMIC	IKENE	DEG_APCC_KENBOX_2	0.7693
p.F2620C	SIDM01611	Endometrial Carcinoma	GDSC	IKENE	DEG_APCC_KENBOX_2	0.3056
p.F2620C	ACH-000996	Endometrial/Uterine Cancer	CCLE	IKENE	DEG_APCC_KENBOX_2	0.3056
p.A2608T	SIDM01588	Endometrial Carcinoma	GDSC	IKENE	DEG_APCC_KENBOX_2	0.1389
p.A2608T	ACH-000993	Endometrial/Uterine Cancer	CCLE	IKENE	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25054	Adenomatous polyposis coli protein	DEG_APCC_KENBOX_2	2615:2619	IKENE	APC,CDC20,FZR1	0.9967	More...
Q6XYQ8	Synaptotagmin-10	DEG_APCC_KENBOX_2	116:120	IKENE	APC,CDC20,FZR1	0.6234	More...
Q9H2G2	STE20-like serine/threonine-protein kinase	DEG_APCC_KENBOX_2	419:423	IKENE	APC,CDC20,FZR1	0.6842	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons