DegronMD - Q9H2G2(SLK)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I457L	TCGA-4R-AA8I	LIHC	TCGA	GKENN	DEG_APCC_KENBOX_2	450:454	Mutation rewiring degron network	0.25
p.I457L	DO49657	LIHC	ICGC	GKENN	DEG_APCC_KENBOX_2	450:454	Mutation rewiring degron network	0.25
p.L1060F	TCGA-69-7980	LUAD	TCGA	ERARLPKIQ	DEG_APCC_DBOX_1	1067:1075	Mutation rewiring degron network	0.1389
p.L1060F	DO23678	LUAD	ICGC	ERARLPKIQ	DEG_APCC_DBOX_1	1067:1075	Mutation rewiring degron network	0.1389
p.E1058K	TCGA-A2-A0SY	BRCA	TCGA	ERARLPKIQ	DEG_APCC_DBOX_1	1067:1075	Mutation rewiring degron network	0.0833
p.E1058K	DO2961	BRCA	ICGC	ERARLPKIQ	DEG_APCC_DBOX_1	1067:1075	Mutation rewiring degron network	0.0833
p.K429T	TCGA-AA-A010	COAD	TCGA	KRPKLENLP	DEG_APCC_DBOX_1	426:434	Mutation altering degron motif	0.6195
p.E505D	TCGA-AX-A2HC	UCEC	TCGA	SQETGE	DEG_Kelch_Keap1_1	503:508	Mutation altering degron motif	0.5647
p.E505D	DO41572	UCEC	ICGC	SQETGE	DEG_Kelch_Keap1_1	503:508	Mutation altering degron motif	0.5647
p.E437D	TCGA-B5-A0JY	UCEC	TCGA	KRPKLENLP	DEG_APCC_DBOX_1	426:434	Mutation rewiring degron network	0.25
p.E437D	DO43041	UCEC	ICGC	KRPKLENLP	DEG_APCC_DBOX_1	426:434	Mutation rewiring degron network	0.25
p.N454Y	TCGA-BH-A0DK	BRCA	TCGA	GKENN	DEG_APCC_KENBOX_2	450:454	Mutation altering degron motif	0.5948
p.N454Y	DO1305	BRCA	ICGC	GKENN	DEG_APCC_KENBOX_2	450:454	Mutation altering degron motif	0.5948
p.R824W	TCGA-BR-8361	STAD	TCGA	RRQELRELR	DEG_APCC_DBOX_1	827:835	Mutation rewiring degron network	0.25
p.R824W	DO222445	BTCA	ICGC	RRQELRELR	DEG_APCC_DBOX_1	827:835	Mutation rewiring degron network	0.25
p.R824W	DO233254	GACA	ICGC	RRQELRELR	DEG_APCC_DBOX_1	827:835	Mutation rewiring degron network	0.25
p.R824W	DO48032	STAD	ICGC	RRQELRELR	DEG_APCC_DBOX_1	827:835	Mutation rewiring degron network	0.25
p.M456T	TCGA-BS-A0UJ	UCEC	TCGA	GKENN	DEG_APCC_KENBOX_2	450:454	Mutation rewiring degron network	0.2778
p.M456T	DO42745	UCEC	ICGC	GKENN	DEG_APCC_KENBOX_2	450:454	Mutation rewiring degron network	0.2778
p.D749G	TCGA-D9-A6EC	SKCM	TCGA	DSGTGST	DEG_SCF_TRCP1_1	749:755	Mutation altering degron motif	0.7198
p.D749G	DO50291	SKCM	ICGC	DSGTGST	DEG_SCF_TRCP1_1	749:755	Mutation altering degron motif	0.7198
p.K723E	TCGA-DD-A3A9	LIHC	TCGA	NSDSGE	DEG_Kelch_Keap1_1	716:721	Mutation rewiring degron network	0.2778
p.K723E	DO44888	LIHC	ICGC	NSDSGE	DEG_Kelch_Keap1_1	716:721	Mutation rewiring degron network	0.2778
p.L709V	TCGA-DK-A3IS	BLCA	TCGA	NSDSGE	DEG_Kelch_Keap1_1	716:721	Mutation rewiring degron network	0.1389
p.L709V	DO566	BLCA	ICGC	NSDSGE	DEG_Kelch_Keap1_1	716:721	Mutation rewiring degron network	0.1389
p.R828H	TCGA-EA-A3HS	CESC	TCGA	RRQELRELR	DEG_APCC_DBOX_1	827:835	Mutation altering degron motif	0.8244
p.R828H	DO6260	CESC	ICGC	RRQELRELR	DEG_APCC_DBOX_1	827:835	Mutation altering degron motif	0.8244
p.L837F	TCGA-EE-A20C	SKCM	TCGA	RRQELRELR	DEG_APCC_DBOX_1	827:835	Mutation rewiring degron network	0.2778
p.L837F	DO222775	MELA	ICGC	RRQELRELR	DEG_APCC_DBOX_1	827:835	Mutation rewiring degron network	0.2778
p.L837F	DO47665	SKCM	ICGC	RRQELRELR	DEG_APCC_DBOX_1	827:835	Mutation rewiring degron network	0.2778
p.E741D	TCGA-EO-A3AV	UCEC	TCGA	DSGTGST	DEG_SCF_TRCP1_1	749:755	Mutation rewiring degron network	0.1111
p.E741D	DO52412	UCEC	ICGC	DSGTGST	DEG_SCF_TRCP1_1	749:755	Mutation rewiring degron network	0.1111
p.E1078D	TCGA-FI-A2D5	UCEC	TCGA	ERARLPKIQ	DEG_APCC_DBOX_1	1067:1075	Mutation rewiring degron network	0.25
p.E1078D	DO41331	UCEC	ICGC	ERARLPKIQ	DEG_APCC_DBOX_1	1067:1075	Mutation rewiring degron network	0.25
p.S750L	TCGA-FI-A2EY	UCEC	TCGA	DSGTGST	DEG_SCF_TRCP1_1	749:755	Mutation altering degron motif	0.7667
p.S750L	DO40984	UCEC	ICGC	DSGTGST	DEG_SCF_TRCP1_1	749:755	Mutation altering degron motif	0.7667
p.G727S	TCGA-GL-6846	KIRP	TCGA	NSDSGE	DEG_Kelch_Keap1_1	716:721	Mutation rewiring degron network	0.1667
p.G727S	DO20808	KIRP	ICGC	NSDSGE	DEG_Kelch_Keap1_1	716:721	Mutation rewiring degron network	0.1667
p.R1082Q	TCGA-IB-7651	PAAD	TCGA	ERARLPKIQ	DEG_APCC_DBOX_1	1067:1075	Mutation rewiring degron network	0.1389
p.R1082Q	DO46657	PAAD	ICGC	ERARLPKIQ	DEG_APCC_DBOX_1	1067:1075	Mutation rewiring degron network	0.1389
p.R1082Q	ACH-000928	Endometrial/Uterine Cancer	CCLE	ERARLPKIQ	DEG_APCC_DBOX_1	1067:1075	Mutation rewiring degron network	0.1389
p.Q504K	TCGA-KQ-A41N	BLCA	TCGA	SQETGE	DEG_Kelch_Keap1_1	503:508	Mutation altering degron motif	0.5833
p.Q504K	DO223588	BLCA	ICGC	SQETGE	DEG_Kelch_Keap1_1	503:508	Mutation altering degron motif	0.5833
p.T1065I	TCGA-OR-A5LE	ACC	TCGA	ERARLPKIQ	DEG_APCC_DBOX_1	1067:1075	Mutation rewiring degron network	0.2778
p.D493N	DO222762	COCA	ICGC	SQETGE	DEG_Kelch_Keap1_1	503:508	Mutation rewiring degron network	0.0556
p.A756S	DO229026	LICA	ICGC	ADTSS	DEG_SPOP_SBC_1	756:760	Mutation altering degron motif	0.7588
p.D517V	DO231593	LINC	ICGC	SQETGE	DEG_Kelch_Keap1_1	503:508	Mutation rewiring degron network	0.0833
p.T506A	DO23186	LINC	ICGC	SQETGE	DEG_Kelch_Keap1_1	503:508	Mutation altering degron motif	0.825
p.I444N	DO52656	MALY	ICGC	KRPKLENLP	DEG_APCC_DBOX_1	426:434	Mutation rewiring degron network	0.0556
p.I444N	DO52656	MALY	ICGC	GKENN	DEG_APCC_KENBOX_2	450:454	Mutation rewiring degron network	0.1667
p.S779L	DO222662	MELA	ICGC	DSGSIS	DEG_SCF_TRCP1_1	776:781	Mutation altering degron motif	0.7667
p.S779L	DO35442	PACA	ICGC	DSGSIS	DEG_SCF_TRCP1_1	776:781	Mutation altering degron motif	0.7667
p.S779L	SIDM00330	Neuroblastoma	GDSC	DSGSIS	DEG_SCF_TRCP1_1	776:781	Mutation altering degron motif	0.7667
p.L823F	DO229234	THCA	ICGC	RRQELRELR	DEG_APCC_DBOX_1	827:835	Mutation rewiring degron network	0.2222
p.N748H	SIDM00935	Other Solid Cancers	GDSC	DSGTGST	DEG_SCF_TRCP1_1	749:755	Mutation rewiring degron network	0.3056
p.N748H	SIDM00935	Other Solid Cancers	GDSC	ADTSS	DEG_SPOP_SBC_1	756:760	Mutation rewiring degron network	0.1111
p.A1084D	SIDM01259	B-Lymphoblastic Leukemia	GDSC	ERARLPKIQ	DEG_APCC_DBOX_1	1067:1075	Mutation rewiring degron network	0.0833
p.A1084D	ACH-001669	Leukemia	CCLE	ERARLPKIQ	DEG_APCC_DBOX_1	1067:1075	Mutation rewiring degron network	0.0833
p.A1084D	ACH-002238	Leukemia	CCLE	ERARLPKIQ	DEG_APCC_DBOX_1	1067:1075	Mutation rewiring degron network	0.0833
p.A1084D	GR-ST	haematopoietic and lymphoid tissue	COSMIC	ERARLPKIQ	DEG_APCC_DBOX_1	1067:1075	Mutation rewiring degron network	0.0833
p.R1076C	SIDM00193	Colorectal Carcinoma	GDSC	ERARLPKIQ	DEG_APCC_DBOX_1	1067:1075	Mutation rewiring degron network	0.3056
p.R1076C	ACH-000991	Colon/Colorectal Cancer	CCLE	ERARLPKIQ	DEG_APCC_DBOX_1	1067:1075	Mutation rewiring degron network	0.3056
p.R1076C	SNU-81	large intestine	COSMIC	ERARLPKIQ	DEG_APCC_DBOX_1	1067:1075	Mutation rewiring degron network	0.3056
p.E821K	SIDM00101	Mesothelioma	GDSC	RRQELRELR	DEG_APCC_DBOX_1	827:835	Mutation rewiring degron network	0.1667
p.D493G	SIDM01770	Gastric Carcinoma	GDSC	SQETGE	DEG_Kelch_Keap1_1	503:508	Mutation rewiring degron network	0.0556
p.D493G	ACH-000908	Gastric Cancer	CCLE	SQETGE	DEG_Kelch_Keap1_1	503:508	Mutation rewiring degron network	0.0556
p.S728Y	SIDM01611	Endometrial Carcinoma	GDSC	NSDSGE	DEG_Kelch_Keap1_1	716:721	Mutation blocking phosphorylation signal	0.5833
p.S728Y	ACH-000996	Endometrial/Uterine Cancer	CCLE	NSDSGE	DEG_Kelch_Keap1_1	716:721	Mutation blocking phosphorylation signal	0.5833
p.A844S	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	RRQELRELR	DEG_APCC_DBOX_1	827:835	Mutation rewiring degron network	0.0833
p.A844S	ACH-000925	Lung Cancer	CCLE	RRQELRELR	DEG_APCC_DBOX_1	827:835	Mutation rewiring degron network	0.0833
p.R832W	SIDM01588	Endometrial Carcinoma	GDSC	RRQELRELR	DEG_APCC_DBOX_1	827:835	Mutation altering degron motif	0.7523
p.R832W	ACH-000993	Endometrial/Uterine Cancer	CCLE	RRQELRELR	DEG_APCC_DBOX_1	827:835	Mutation altering degron motif	0.7523

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLK

UniProt ID: Q9H2G2

Entrez ID: 9748

Protein name: STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLK in